Devika Soundara Manickam, Ph.D.

Research Instructor

Department of Pharmaceutical Sciences                                                  
College of Pharmacy
University of Nebraska Medical Center                                        
985830 Nebraska Medical Center
Omaha, NE 68198-5830
402-559-9021 (Lab)
dsoundara@unmc.edu

Research Activities/Interests: 

1. Non-Viral delivery systems
2. Combined drug and therapeutic nucleic acid delivery
3. Design of cancer therapeutics exploiting alterations in pathological states

Recent Publications:

1. Kylachko, N.L.; Manickam, D.S.; Brynskikh, A.M.; Li, S.; Higginbotham, S.M.; Bronich, T.K; Batrakova, E.V.; Kabanov, A.V.; "Cross Linked Antioxidant Nanozymes for Improved Delivery to CNS." Nanomedicine: Nanotechnology, Biology and Medicine. 2011
2. Rosenbaugh, E.G.; Roat, J.; Gao, L.; Yang, R-F.; Manickam, D.S.; Yin, J-X.; Schultz, H.D.; Bronich, T.K.; Batrakova, E.V.; Kabanov, A.V.; Zucker, I.H.; Zimmerman, M.C.; "Nanoformulated Copper/Zinc Superoxide Dismutase Attenuates Central Angiotensin II-dependent Pressor Response and Intra-neuronal Signaling." Biomaterials, 31 (19), pp. 5218-5226. 2010
3. Manickam, D.S.; Li, J.; Putt, D.A.; Zhou, Q.H.; Wu, C.; Lash, L.H.; Oupicky, D.; "Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors." Journal of Controlled Release, 141, pp. 77-84. 2010
4. Zhou, Q.H.; Wu, C.; Manickam, D.S.; Oupicky, D.; "Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR." Pharmaceutical Research, 26(7), pp. 1581-1589. 2009
5. Wan, L.; Manickam, D.S.; Oupicky, D.; Mao, G.; "DNA release dynamics from reducible polyplexes by atomic force microscopy." Langmuir, 24(21), pp. 12474-12482. 2008
6. Kakade, S.; Manickam, D.S.; Handa, H.; Mao, G.; Oupicky, D.; "Transcfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles." International Journal of Pharmaceutics, 365(1-2), pp. 44-52. 2009
7. Manickam, D.S.; Hirata, A.; Putt, D.A.; Lash, L.H.; Hirata, F.; Oupicky, D.; "Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of reducible gene delivery vectors." Biomaterials, 29, pp. 2680-2688. 2008
8. Rahbeck, U.L.; Howard, K.A.; Oupicky, D.; Manickam, D.S.; Dong, M.; Nielsen, A.F.; Besenbacher, F.; Kjems, J.; "Intracellular siRNA and Precursor miRNA Trafficking Using Bioresponsive Copolypeptides." Journal of Gene Medicine, 10(1), pp. 81-93. 2008
9. You, Y-Z.; Manickam, D.S.; Zhou, Q.; Oupicky, D.; "Dually response multiblock copolymers via RAFT polymerization: Synthesis of temperature- and redox-responsive copolymers of PNIPAM and PDMAEMA." Macromolecules, 40(24), pp. 8617-8624. 2007
10. You, Y-Z.; Manickam, D.S.; Zhou, Q.H.; Oupicky, D.; "A Versatile approach to reducible vinyl polymers via oxidation of telechelic polymers prepared by reversible addition fragmentation chain transfer polymerization." Biomacromolecules, 8, pp. 2038-2044. 2007