Intermolecular interaction, using AFM Force  mode. 

This type of experiments usually needs surface or/and tip chemical modification for covalent  attachment of  molecules, particles, drugs to the surface or/and to the tip.

Click on the image to see a larger, more detailed image.

    Fig 12
Schematic presentation of receptor-ligand interaction.
web 1
Typical AFM force curve reflects the interaction between modified  tip and modified surface.
 web 2  web 3
The histogram  obtained from force interaction measurements between non-modified tip and dentin (left) and enamel (right). Dentin shows two distinct type of interaction, but enamel only one