David Oupicky, Ph.D.

Professor and Center for Drug Delivery and Nanomedicine, Co-Director

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Durham Research Center I
First Floor, Room 1009
985830 Nebraska Medical Center
Omaha, NE 68198-5830
402-559-9363 (Office)
402-559-9365 (Fax)

Research Activities/Interests:
Dr. Oupicky's research is in the broad area of nanomedicine with emphasis on the development of novel approaches to deliver drug combinations to better treat various diseases. Current research focus is on the design of multifunctional nanoparticles with applications in the treatment of metastatic cancer and inflammatory conditions like Crohn's disease.

Please visit the Oupicky Lab website and/or the CDDN website for more information.

Recent Publications:

  1. J. Li, Y. Zhu, S. Hazeldine, C. Li, D. Oupicky. “Dual-function CXCR4 Antagonist Polyplexes to Deliver Gene Therapy and Inhibit Cancer Cell Invasion.” Angew. Chem., Int. Ed., 2012, 51(35), 8740-3.
  2. Y. Dong, Y. Zhu, J. Li, Q. Zhou, C. Wu, D. Oupicky. “Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer.” Mol. Pharm., 2012, 9(6), 1654-64.
  3. J. Li, D. S. Manickam, J. Chen, D. Oupicky. “Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes.” Eur. J. Pharm. Sci., 2012, 46(3), 173-180.
  4. D. S. Manickam, J. Li, D. A. Putt, Q. H. Zhou, C. Wu, L. H. Lash, D. Oupicky. "Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors." J. Controlled Rel., 2010, 141(1), 77-84.
  5. S. R. Bhattarai, E. Muthuswamy, A. Wani, M. Brichacek, A. L. Castaneda, S. Brock, D. Oupicky. “Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine.” Pharm. Res., 2010, 27(12), 2556-2568.
  6. J. Chen, C. Wu, D. Oupicky. "Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery." Biomacromolecules, 2009, 10(10), 2921-2927.
  7. Q. H. Zhou, C. Wu, D. S. Manickam, D. Oupicky. “Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR.” Pharm. Res., 2009, 26(7), 1581-1589.
  8. J. Blacklock, Y. Z. You, Q. H. Zhou, G. Mao, D. Oupicky. “Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA.” Biomaterials, 2009, 30(5), 939-950.
  9. Y. Z. You, K. Kalebaila, S. L. Brock, D. Oupicky. “Temperature-Controlled Uptake and Release in PNIPAM-modified Porous Silica Nanoparticles.” Chemistry of Materials, 2008, 20, 3354-3359.
  10. Y. Z. You, Q. H. Zhou, D. S. Manickam, L Wan, G. Mao, D. Oupicky. “Dually Responsive Multiblock Copolymers via RAFT Polymerization: Synthesis of Temperature- and Redox-Responsive Copolymers of Poly(N-isopropylacrylamide) and Poly(2-(dimethylamino)ethyl methacrylate).” Macromolecules, 2007, 40, 8617-8624.

David Oupicky, Ph.D.
Dr. Oupicky