Brian Robbins, Ph.D.

Research Associate Professor

Manager, Antiviral Pharmacology Laboratory
Department of Pharmacy Practice
College of Pharmacy
University of Nebraska Medical Center
986045 Nebraska Medical Center
Omaha, NE   68198-6045
Phone: 402-559-1939
Fax:  402-559-5060
Email:  blrobbins@unmc.edu

Research Activities/Interests:
In our laboratory we investigate the metabolism, disposition and pharmacokinetics of currently used and new anti-HIV compounds.  This includes a variety of compounds that inhibit most of the known inhibition sites of the HIV life cycle.  These include following classes, protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTI), non nucleoside reverse transcriptase inhibitors (NNRTI) and integrase inhibitors.  Using LC-MS/MS technology we have developed unique assays to quantitate low concentrations of the active forms of the NRTI found in human peripheral blood mononuclear cells and will continue this line of research with some of the other drugs in related tissues of interest such as gut associated lymphoid tissue.  We are also planning to investigate drug levels in dried blood spots to allow easier shipment from remote locations overseas.

Recent Publications:

  1. Robbins BL, Capparelli EV, Chadwick EG, Yogev R, Serchuck L, Worrel C, Smith ME, Alvero C, Fenton T, Heckman B, Pelton SI, Aldrovandi G, Borokowsky W, Rodman J and Havens PL, for the P1038 Team. Pharmacokinetics of High-Dose Lopinavir/Ritonavir with and without Saquinavir or Non-Nucleoside Reverse Transcriptase Inhibitors in HIV Infected Pediatric and Adolescent Patients Previously Treated with Protease Inhibitors (2008) Antimicrob Agents Chemother. Sep;52(9):3276-83.
  2. Sleasman JW, Robbins BL, Cross SJ, Lindsey JC, Kraimer JM, Heckman BE, Sprenger HL, Tustin NB, Rose CH, Poston PA, Neal EF, Pakes GE, Nikanjam M, Capparelli EV. Abacavir Pharmacokinetics During Chronic Therapy in HIV-1 Infected Adolescents and Young Adults (2009) Clin Pharmacol Ther. Apr;85(4):394-401.
  3. Cross SJ, Rodman JH, Lindsey J, Robbins BL, Rose C, Yuen GK and D’Angelo L. Abacavir Pharmacokinetics in HIV-1 Infected Children and Adolescents (2009) J Acquir. Immune. Defic. Syndr. May 1;51(1):54-9.
  4. Chadwick EG, Pinto J, Yogev R, Alvero CG, Hughes MD, Palumbo P, Robbins B, Hazra R, Serchuck L, Heckman BE, Purdue L, Browning R, Luzuriaga K, Rodman J, Caparelli E International Maternal Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team. Early Initiation of Lopinavir/Ritonavir in Infants Less Than 6 Weeks of Age: Pharmacokinetics and 24-Week Safety and Efficacy (2009) Pediatr Infect Dis J. Mar 28(3):215-9.
  5. Delahunty T, Bushman L, Robbins B, Fletcher CV. The Simultaneous Assay of Tenofovir and Emtricitabine in Plasma Using LC/MS/MS and Isotopically Labeled Internal Standards (2009) J Chromatogr B Analyt Technol Biomed Life Sci. Jul 1;877(20-21):1907-14.
  6. Van Schooneveld T, Swindells S, Nelson SR, Robbins BL, Moore R, Fletcher CV. Clinical Evaluation of a Dried Blood Spot Assay for Atazanavir (2010) Antimicrob Agents Chemther. Oct;54(10)4124-8.
  7. Chadwick EG, Yogev R, Alvero CG, Hughes MD, Hazra R, Pinto JA, Robbins BL, Heckman BE, Palumbo PE, Capparelli EV, International Maternal Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team.  Long term Outcomes for HIV-Infected Infants Less than 6 Months of Age at Initiation of Lopinavir/Ritonavir Combination Antiretroviral Therapy (2011) AIDS Mar 13; 25(5):643-9.
  8. Flynn PM, Mirochnick M, Shapiro DE, Bardeguez A, Rodman J, Robbins B, Huang S, Fiscus SA, Van Rompay KK, Rooney JF, Kearney B, Mofenson LM, Watts DH, Jean-Philippe P, Heckman B, Thorpe E Jr., Cotter A, Purswani M, PACTG 394 Study Team, Pharmacokinetics and Safety of Single-Dose Tenofovir Disoproxil Fumarate and Emtricitabine in HIV-1-infected Pregnant Women and their Infants. (2011) Antimicrob. Agents Chemother. Dec;55(12):5914-22.
  9. Nakanjam M, Chadwick EG, Robbins B, Alvero C, Palumbo P, Yogev R, Pinto J, Hazra R, Hughes ML, Heckman BE, Capparelli EV. Assessment of Lopinavir Pharmacokinetics With Respect to Developmental Changes in Infants and the Impact on Weight Band-Based Dosing. (2012) Clin Pharmacol Ther. Feb;91(2):243-9.
  10. Robbins BL, Nelson SR, Fletcher CV. A Novel Ultrasensitive LC-MS/MS Assay for Quantification of Intracellular Raltegravir in Human Cell Extracts (2012) J of Pharm Biomed. Anal. Nov;70:378-87.

Brian Robbins, Ph.D.
Brian Robbins
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