Jonathan L. Vennerstrom, Ph.D.
Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986025 Nebraska Medical Center
Omaha, NE 68198-6025
402-559-5362 (Office)
402-559-9543 (Fax)
jvenners@unmc.edu
Teaching Activities:
Dr. Vennerstrom lectures in Medicinal Chemistry I and Medicinal Chemistry II where he is course coordinator. At the graduate level Dr. Vennerstrom is the course coordinator for Advanced Medicinal Chemistry and Organic Spectroscopic Structural Analysis and he lectures in Innovative Drug Delivery Systems.
Research Activities/Interests:
The research activity of Dr. Vennerstrom’s laboratory is focused on antimalarial drug design and synthesis and on the investigation of heme as a mechanistic intersection for antimalarial drugs.
Recent Publications:
- Vennerstrom J.L., Arbe-Barnes S., Brun R., Charman S.A., Chiu F.C.K., Chollet J., Dong Y., Dorn A., Hunziker D., Matile H., McIntosh K., Padmanilayam M., Santo Tomas J., Scheurer C., Scorneaux B., Tang Y., Urwyler H., Wittlin S., Charman W.N. Identification of an Antimalarial Synthetic Trioxolane Drug Development Candidate. Nature 430, 900-904 (2004).
- Tang Y., Dong Y., Karle J.M., DiTusa C.A., Vennerstrom J.L. Synthesis of Tetrasubstituted Ozonides by the Griesbaum Coozonolysis Reaction: Diastereoselectivity and Functional Group Transformations by Post-Ozonolysis Reactions. J. Org. Chem. 69, 6470-6473 (2004).
- Tang Y., Dong Y., Vennerstrom J.L. The Reaction of Carbonyldiimidazole with Alcohols to Form Carbamates and N-Alkylimidazoles. Synthesis 2540-2544 (2004).
- Tang T.; Dong Y.; Wang X.; Sriraghavan K.; Wood J.K.; Vennerstrom J.L. Dispiro-1,2,4-trioxane Analogs of a Prototype Dispiro-1,2,4-trioxolane: Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron (II). J. Org. Chem. 5103-5110 (2005).
- Perry C.S.; Charman S.A.; Prankerd R. J.; Chiu F. C. K.; Dong Y.; Vennerstrom J.L.; Charman W.N. Chemical Kinetics and Aqueous Degradation Pathways of a New Class of Synthetic Ozonide Antimalarials. J. Pharm. Sci. 95, 737-747(2006).
