UNMC | Jonathan L. Vennerstrom, Ph.D.

Jonathan L. Vennerstrom, Ph.D.

Vennerstrom Professor and Interim Chair of Pharmaceutical Sciences
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986025 Nebraska Medical Center
Omaha, NE 68198-6025
402-559-5362 (Office)
402-559-9543 (Fax)
jvenners@unmc.edu

Teaching Activities:
Dr. Vennerstrom lectures in Medicinal Chemistry I and Medicinal Chemistry II where he is course coordinator. At the graduate level Dr. Vennerstrom is the course coordinator for Advanced Medicinal Chemistry and Organic Spectroscopic Structural Analysis and he lectures in Innovative Drug Delivery Systems.

Research Activities/Interests:
The research activity of Dr. Vennerstrom’s laboratory is focused on antiparasitic drug discovery, particularly antimalarial drug design and synthesis and the investigation of heme as a mechanistic intersection for antimalarial drugs. Work is also ongoing in the discovery of new inhibitors of Botulinum neurotoxin.

Recent Publications:

Tang T.; Dong Y.; Wang X.; Sriraghavan K.; Wood J.K.; Vennerstrom J.L.; Dispiro-1,2,4-trioxane Analogs of a Prototype Dispiro-1,2,4-trioxolane: Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron (II). J. Org. Chem. pp.5103-5110 2005
Kaiser, M.; Wittlin, S.; Nehrbass-Stuedli, A.; Dong, Y.; Wang, X.; Hemphill, A.; Matile, H.; Brun, R.; Vennerstrom, J.L.; Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160). Antimicrob. Agents Chemother., 51, pp. 2991-2993. 2007
Flaherty, D.P.; Walsh, S.M.; Kiyota, T.; Dong, Y.; Ikezu, T.; Vennerstrom, J.L.; Polyfluorinated Bix-styrylbenzene B-Amyloid Plaque Binding Ligands. J. Med.Chem., 50, pp.4986-4992. 2007
Wang, X.; Dong, Y.; Wittlin, S.; Creek, D.; Chollet, J.; Charman, S.A.; Santo-Tomas, J.; Scheurer, C.; Snyder, C.; Vennerstrom, J.L.; Spiro and Dispiro-1,2-dioxolanes: Contribution of Iron (II)-mediated One-electron vs Two-electron Reduction to the Activity of Antimalarial Peroxides. J. Med. Chem., 50, pp. 5840-5847. 2007
Creek, D.J.; Charman, W.N.; Chiu, F.C.K.,; Prankerd, R.J.; Dong, Y.; Vennerstrom, J.L.; Charman, S.A.; Relationship between Antimalarial Activity and Haem Alkylation for Spiro and Dispiro-1,2,4-trioxolane Antimalarials. Antimicrob. Agents Chemother.,52, pp.1291-1296. 2008
Hermone, A.R.; Burnett, J.C.; Nuss, J.E.; Tressler, L.E.; Nguyen, T.L.; Solaja, B.A.; Vennerstrom, J.L.; Schmidt, J.J.; Wipf, P.; Bavari, S.; Gussio, R.; Three-dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-zone Pharmacophore. ChemMedChem, 3, pp. 1905-1912. 2008
Flaherty, D.P.; Dong, Y.; Vennerstrom, J.L.; A One-pot Synthesis of Unsymmetrical Bis-styrylbenzenes. Tetrahedron Lett., 50, pp. 6228-6230. 2009
Dong, Y.; Wittlin, S.; Sriraghavan, K.; Chollet, J.; Charman, S.A.; Charman, W.N.; Scheurer, C.; Urwyler, H.; Santo-Tomas, J.; Snyder, C.; Creek, D.J.; Morizzi, J.; Koltun, M.; Matile, H.; Wang, X.; Padmanilayam, M.; Tang, Y.; Dorn, A.; Brun, R.; Vennerstrom, J.L.; The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ2777), J.Med.Chem., 53, pp. 481-491. 2010
Nuss, J.E.; Dong, Y.; Wanner, L.M.; Ruthel, G.; Wipf, P.; Gussio, R.; Vennerstrom, J.L.; Bavari, S.; Burnett, J.C.; Pharmacophore Refinement Guides the Design of Nanomolar-Range Botulinum Neurotoxin Serotype A Light Chain Inhibitors. ACS Med.Chem.Lett., 1, pp. 301-305. 2010
Charman, S.A.; Arbe-Barnes, S.; Bathurst, I.C.; Brun, R.; Campbell, M.; Charman, W.N.; Chiu, F.C.K.; Chollet, J.; Craft, C.J.; Creek, D.J.; Dong, Y.; Matile, H.; Maurer, M.; Morizzi, J.; Nguyen, T.; Papastogiannidis, P.; Scheurer, C.; Shackleford, D.M.; Sriraghavan, K.; Stingelin, L.; Tang, Y.; Urwyler, H.; Wang, X.; White, K.L.; Wittlin, S.; Zhou, L.; Vennerstrom, J.L.; Synthetic Ozonide Drug Candidate OX439 Offers New Hope For a Single-dose Cure of Uncomplicated Malaria. Proc. Natl. Acad. Sci.,108, pp. 4400-4405. 2011