Serguei Vinogradov, Ph.D.

Research Professor

VinogradovDepartment of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Room #3037, 4046
986025 Nebraska Medical Center
Omaha, NE 68198-6025
Tel: (402) 559-9362
Fax: (402) 559-9543
vinograd@unmc.edu

Teaching Activities:
Dr. Vinogradov teaches in the Innovative Drug Delivery Course.

Research Activities/Interests:

  • Nanogels as Drug Delivery Systems;
  • Nanoformulations of Antiviral and Anticancer Nucleoside Inhibitors;
  • Therapy of Drug-Resistant Tumors
  • Drug Delivery across the Blood-Brain Barrier;
  • Nanocarriers for Non-Viral Gene Therapy;
  • Cancer- and Tissue Targeting of Nanoformulations;

Please visit the Nanomedicine Group Website for further information.

Recent Publications:

  1. Vinogradov SV, Wei X. Cancer stem cells and drug resistance: potentials of nanomedicine. Nanomedicine (London), 7(4): 597-615, 2012
  2. Senanayake TH, Warren G, Vinogradov SV. Novel anticancer polymeric conjugates of activated nucleoside analogs. Bioconjug Chem. 22(10): 1983-93, 2011
  3. Banks WA, Gertler A, Solomon G, Niv-Spector L, Shpilman M, Yi X, Batrakova E, Vinogradov S, Kabanov AV. Principles of strategic drug delivery to the brain (SDDB): development of anorectic and orexigenic analogs of leptin. Physiol Behav. 105(1): 145-149, 2011
  4. Ambardekar VV, Han H-Y, Varney ML, Vinogradov SV, Singh RK, Vetro JA. The Modification of siRNA with 3' Cholesterol to Increase Nuclease Protection and Suppression of Native mRNA by Select siRNA Polyplexes. Biomaterials 32: 1404-1411, 2011
  5. Galmarini CM, Warren G, Senanayake MT, Vinogradov SV. Efficient Overcoming of Drug Resistance to Anticancer Nucleoside Analogs by Nanodelivery of Active Phosphorylated Drugs. Int J Pharm 395: 281-289, 2010
  6. Zhang H, Gerson T, Varney ML, Singh RK, Vinogradov SV. Multifunctional Peptide-PEG Intercalating Conjugates: Programmatic of Gene Delivery to the Blood-Brain Barrier. Pharm Res 27: 2528-2543, 2010
  7. Vinogradov SV, Poluektova LY, Makarov E, Gerson T, Senanayake MT. Nano-NRTIs: Efficient Inhibitors of HIV type-1 in Macrophages with a Reduced Mitochondrial Toxicity. Antivir Chem Chemother 21: 1-14. 2010
  8. Kabanov AV, Vinogradov SV. Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities. Angew Chem Intern Ed 48 (30): 5418-5429, 2009
  9. Yi Xiang, Batrakova E, Banks WA, Vinogradov SV, Kabanov AV. Protein Conjugation with Amphiphilic Block Copolymers for Enhanced Cellular Delivery. Bioconjug Chem 19(5): 1071-1077, 2008
  10. Vinogradov, S.V.; Polymeric Nanogel Formulations of Nucleoside Analogs. Expert Opin Drug Deliv 4: 5-17, 2007