Serguei Vinogradov, Ph.D.

Serguei Vinogradov, Ph.D.

VinogradovResearch Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Durham Research Center
First Floor, Room #1009
985830 Nebraska Medical Center
Omaha, NE 68198-5830
Tel: (402) 559-9362
Fax: (402) 559-9365
vinograd@unmc.edu

Teaching Activities:
Dr. Vinogradov teaches in the Innovative Drug Delivery Course.

Research Activities/Interests:

  • Nanogels as Drug Delivery Systems;
  • Chemistry of Antiviral and Anticancer Nucleoside Inhibitors;
  • Drug Delivery across the Blood-Brain Barrier;
  • Polymer Drug Carriers for Non-Viral Gene Therapy;
  • Cancer- and Tissue Targeting of Polymer Drug Carriers;
  • Therapeutic Applications of Antisense Oligos and siRNA;

Please visit the Nanomedicine Group Website for further information.

Recent Publications:

  1. Vinogradov, S.V.; Polymeric Nanogel Formulations of Nucleoside Analogs. Expert Opin Drug Deliv. 4: pp. 5-17. 2007
  2. Kohli, E.; Han, H-Y.; Zeman A.D.; Vinogradov, S.V.; Formulations of Biodegradable Nanogel Carriers with 5'-triphosphates of Nucleoside Analogs that Display a Reduced Cytotoxicity and Enhanced Drug Activity. J Control Release. 121: pp. 19-27. 2007
  3. Yi, Xiang; Batrakova, E.; Banks, W.A.; Vinogradov, S.V.; Kabanov, A.V.; Protein Conjugation with Emphiphilic Block Copolymers for Enhanced Cellular Delivery. Bioconjug Chem. 19 (5): pp. 1071-1077. 2008
  4. Galmarini, C.M.; Warren, G.; Kohli, E.; Zeman, A.; Mitin, A.; Vinogradov, S.V.; Polymeric Nanogels Containing The Triphosphate Form of Cytotoxic Nucleoside Analogues Show Antitumor Activity Against Breast and Colorectal Cancer Cell Lines. Mol Cancer Ther. 7 (10): pp. 3373-3380. 2008
  5. Zhang, H.; Mitin, A.; Vinogradov, S.V.; Efficient Transfection of Blood-Brain Barrier Endothelial Cells by Lipoplexes and Polyplexes in the Presence of Nuclear Targeting NLS-PEG-acridine Conjugates. Bioconjug Chem. 20 (1): pp. 120-128. 2009
  6. Kabanov, A.V.; Vinogradov, S.V.; Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities. Angew Chem Intern Ed. 48 (30): pp. 5418-5429. 2009
  7. Vinogradov, S.V.; Poluektova, L.Y.; Makarov, E.; Gerson, T.; Senanayake, M.T.; Nano-NRTIs: Efficient Inhibitors of HIV type-1 in Macrophages with a Reduced Mitochondrial Toxicity. Antivor Chem Chemother. 21: pp. 1-14. 2010
  8. Zhang, H.; Gerson, T.; Varney, M.L.; Singh, R.K.; Vinogradov, S.V.; Multifunctional Peptide-PEG Intercalating Conjugates: Programmatic of Gene Delivery to the Blood-Brain Barrier. Pharm Res. 27: pp. 2528-2543. 2010
  9. Galmarini, C.M.; Warren, G.; Senanayake, M.T.; Vinogradov, S.V.; Efficient Overcoming of Drug Resistance to Anticancer Nucleoside Analogs by Nanodelivery of Active Phosphorylated Drugs. Int J Pharm. 395: pp. 281-289. 2010
  10. Ambardekar, V.V.; Han, H-Y.; Varney, M.L.; Vinogradov, S.V.; Singh, R.K.; Vetro, J.A.; The Modification of siRNA with 3' Cholesterol to Increase Nuclease Protection and Supression of Native mRNA by Select siRNA Polyplexes. Biomaterials. 32: pp. 1404-1411. 2011