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A.V.Kabanov

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Polymer Therapeutics 

Advanced Pharmaceutics I PHSC 885

 

Contents

  • About this educational material

  • Syllabus

  • Problems

  • Textbooks

  • About this educational material

  • This current course is based on the lectures that Dr. Alexander (Sasha) Kabanov taught to the graduate students in Advanced Pharmaceutics I course (PHSC 885) in the Fall 1998. The slides were upgraded with the notes and posted as a supplementary material to enhance learning of physicochemical principles of pharmaceutical sciences by the students in the Pharmaceutical Sciences Graduate Program (PSGP) at UNMC.

  • The instructor’s intention is to further upgrade this course with chapters on Process (including kinetics and catalysis, diffusion and mass transfer, elements of macrokinetics, rheology) and Polymers (including polymer solutions, polyelectrolytes and polyelectrolyte complexes, block copolymers and methods of investigation). The upgrades and modifications will be carried upon teaching of the corresponding parts in the PSGP courses. It is anticpated that some chapters on Processes and Polymers will be taught and posted in the fall of 1999 in Advanced Pharmaceutics II course (PHSC 886). Instructor is working on improvement of the exhisting notes, slides and organization of the material and will greatly appreciate your comments that may help this work.

  • Hopefully, this effort will yield an advanced WWW educational tool, which will enhance learning of principles of physical, colloidal and polymer chemistry, necessary for pharmaceutical scientists, particularly, those individuals working on drug delivery/release systems, gene therapy and related applications. Also, the objective is to promote and enhance knowledge of the polymer and colloidal science among the non-polymer students, scientists and educators, who need this knowledge in their academic and research activities. It is recognized that number of such individuals has grown tremendously as a result of multidisciplinary research in life sciences, pharmaceutics, and medicine.

  • This course also serves as a prototype model of WWW courses in chemical and biological disciplines. In future such courses can be linked together into a global educational network that will promote education "across the borders". It has a potential of utilizing advanced educational tools developed in several Departments and Colleges in University of Nebraska as well as other universities in the United States and other countries.

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    Syllabus

     

    Part 1: Solutions

  • Water

  • Energy and Forces

  • Solution Thermodynamics

  • Colligative properties

  • Chemical Equilibrium

  • Solubility

  • Solutions of Electrolytes

  • Acids and Base

  • Buffers

  • Isotonic solutions

  •  

    Part 2: Surfaces and Colloids

  • Surface Tension

  • Adsorption

  • Dispersions

  • Surfactants in Solution

  • Pharmaceutical Suspensions and Emulsions

  •  

     

    Textbooks

     

    Two books have been particularly useful in this part of the course:

    • For physical chemical principles, including thermodynamics: P. Atkins, Physical Chemistry, W.H. Freeman and Co., New York, 1994.

    • For all theory, solubility, acid-base and buffer capacity calculations: A. Martin, Physical Pharmacy, Lea and Febiger, Philadelphia, London, 1993.

    • For tonicity calculations, computation of HLB, moles, moles and gram equivalents: M. Stoklosa and H. Ansel, Pharmaceutical Calculations, Williams & Wilkins, Baltimore, 1996.

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