Matthew Kelso

Matthew Kelso
Curriculum Vitae

Assistant Professor
Pharm. D. 2003, University of Nebraska Medical Center
Ph.D. 2009, University of Kentucky
Specialty: Neurophysiology
Major Interest: Oxidative stress following traumatic brain injury

Research in the laboratory is concerned with the pathophysiology of traumatic brain injury (TBI) and the testing of therapeutic agents. TBI is the result of a mechanical trauma followed by a complex complex biochemical cascade, ultimately ending with cellular death. Currently, we are studying the role of oxidative stress and the use of novel antioxidant formulations created at UNMC. Oxidative stress is one of the most significant mechanisms of secondary brain damage following traumatic brain injury (TBI). Free radical production begins immediately following injury and continues to be a major factor in the later post-traumatic period. Once initiated, these radicals form reactive oxygen species (ROS) that can interact with lipids that are highly enriched in the brain and highly susceptible to peroxidation. The resulting lipid peroxidation products are toxic and a large body of work has gone into targeting these species in the pathophysiology of TBI.

Additional on-going projects include the influence of TBI on platelet physiology, the characterization of a novel model of blast TBI, and the use of magnetic resonance elastography to elucidate the mechanical properties of the brain following injury.

  1. Kelso ML, Wehner JM, Collins AC, Scheff SW, Pauly JR. The pathophysiology of traumatic . brain injury in alpha7 nicotinic cholinergic receptor knockout mice. Brain Res. 2006 Apr 14;1083(1):204-10. PMID:16545784
  2. Kelso ML, Scheff SW, Pauly JR, Loftin CD. Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. BMC Neurosci. 2009 Aug 31;10(1):108. PMID:19719848
  3. Morris SA, Kelso ML, Liput DJ, Marshall SA, Nixon K. Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence. Alcohol. 2010 Feb;44(1):89-98. PMID:20113877
  4. Kelso ML, Scheff NN, Scheff SW, Pauly JR. Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury. Neurosci Lett. 2011 Jan 13;488(1):60-4. PMID:21056621
  5. Kelso ML, Pauly JR. Therapeutic Targets for Neuroprotection and/or Enhancement of Functional Recovery Following Traumatic Brain Injury. Prog Mol Biol Transl Sci. 2011;98:85-131. PMID:21199771