Karla Haack
Curriculum Vitae

Ph.D. 2009, Georgia Institute of Technology
Specialty: Molecular  Neurophysiology
Major Interest: Cellular mechanisms underlying autonomic imbalance in chronic heart failure.

Research in our laboratory focuses on the regulation of neurohormones acting on the cardiovascular system during chronic heart failure (CHF).  My work focuses on the regulation of the Angiotensin II type 1 receptor (AT1R) by downstream pathways in the rostral ventrolateral medulla (RVLM) during CHF.  G protein coupled receptor kinase 5 (GRK5) phosphorylates AT1R to decrease receptor abundance following ligand binding.  In CHF, AT1R, NF-kB (a pro-inflammatory cytokine that also drives AT1R expression) and GRK5 are upregulated in cardiovascular control regions of the brain.  I utilize a combination of in vitro approaches and whole animal techniques to identify the mechanism(s) by which GRK5 may be protective via its regulation of AT1R and NF-kB in the brain during CHF, and the subsequent effects on neuronal hyperexcitability and autonomic imbalance. An additional research interest is the contribution(s) of the central RhoA/ROCKII pathway to AT1R regulation and autonomic imbalance in CHF.

AT1R regulation

Recent publications:

  1. Haack KK, Mitra AK, Zucker IH.  NF-κB and CREB are required for Angiotensin II type 1 receptor upregulation in neurons. PLoS One. 2013 Nov 11;8(11):e78695. PMID: 24244341
  2. Schiller AM, Haack KK, Pellegrino PR, Curry PL, Zucker IH. Unilateral renal denervation improves autonomic balance in conscious rabbits with chronic heart failure. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 15;305(8):R886-92. PMID: 24005248
  3. Xiao L, Haack KK, Zucker IH. Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling. Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1073-9. PMID: 23535237
  4. Haack KK, Gao L, Schiller AM, Curry PL, Pellegrino PR, Zucker IH. Central rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure. Hypertension. 2013 Mar;61(3):723-9. PMID: 23283363
  5. Haack KK, Engler CW, Papoutsi E, Pipinos II, Patel KP, Zucker IH. Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure. Hypertension. 2012 Aug;60(2):354-61. PMID: 22753221