Yu-Long Li
Curriculum Vitae

Assistant Professor
M.D. 1984, Hebei Medical University Ph.D. 1994, Hebei Medical University
Specialty: Cardiovascular Physiology
Major Interest: Reflex regulation of cardiovascular function, and the cellular and molecular mechanism of reflex regulation.

The goal of research in this laboratory is to understand the mechanisms of attenuated parasympathetic control of the baroreflex in experimental diabetes and chronic heart failure (CHF). The arterial baroreflex is an important component of the body's neural cardiovascular control circuit. Aortic depressor afferent nerve-endings and the nodose ganglia (NG) containing the cell bodies of the aortic baroreceptor afferent nerve (AB neuron cell) serve as the primary afferent limb of the baroreceptor reflex. Dysfunction of the primary afferent limb of the baroreceptor reflex is likely to be involved in the blunted baroreflex sensitivity observed in the diabetes and CHF state. The changes in baroreflex, endogenous substances (such as angiotensin II, nitric oxide, etc), oxidative stress (such as reactive oxygen species, ROS), and cell function (such as cell membrane excitability and ion channel function) are investigated at the molecular, cell, organ and intact animal levels. 
Baroreceptor neurons

Recent Publications:

  1. Tu H, Liu J, Zhu Z, Pipinos II, Li YL. Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart failure rats. J Neurophysiol 2012; 107: 591-602. PMID: 22072507
  2. Liu J, Zhang L, Tu H, Li YL. Angiotensin II induces protein overexpression of hyperpolarization-activated cyclic nucleotide-gated channels in primary cultured nodose neurons. Neurosci Lett2012; 515: 168-173. PMID: 22465246
  3. Liu J, Tu H, Zheng H, Zhang L, Tran TP, Muelleman RL, Li YL. Alterations of calcium channels and cell excitability in intracardiac ganglion neurons from type 2 diabetic rats. Am J Physiol Cell Physiol 2012; 302: C1119-C1127. PMID: 22189553
  4. Liu J, Tu H, Zhang D, Li YL. Changes of calcium channel mRNA, protein and current in NG108-15 cells after cell differentiation. Biochem Biophys Res Commun2012; 423: 55-59. PMID: 22627136
  5. Tran TP, Tu H, Liu J, Muelleman RL, Li YL. Mitochondria-derived superoxide links to tourniquet-induced apoptosis in mouse skeletal muscle. PLoS One 2012; 7: e43410. PMID: 22912870