Shyamal K. Roy

 Shyamal K. Roy
Curriculum Vitae

Ph.D. 1980, All-India Institute of Medical Sciences
Major interest: Reproductive Endocrinology
Specialty: Endocrine regulation of follicular development, growth factors, signal transduction in ovarian cells, and biochemistry of granulosa cells

Estrogen is a female reproductive hormone that regulates a variety of physiological processes.  Evidence indicates that estrogen stimulates the multiplication of granulosa cells that are present in ovarian follicles, and regulates their functions.  However, the mechanisms underlying the estrogen effects on granulosa cell functions remain unclear.  Similarly, despite sporadic information, the role of estrogen in regulating primordial follicle formation in mammals is not clearly understood.  Primordial follicles represent a finite pool of early follicles that provide follicles for ovulation throughout the reproductive life of a female.  A significant number of primordial follicles die during ovary development, and an early depletion of this pool leads to premature ovarian failure, and infertility due to ovarian causes.  Therefore, understanding the factors regulating the formation and development of primordial follicles and the mechanisms of such regulation may lead to improved therapeutic management of infertility.
Working hypothesis image

Recent publications:

  1. Roy SK, Wang C, Mukherjee A, Chakraborty P. In Vitro Culture of Fetal Ovaries: A Model to Study Factors Regulating Early Follicular Development. Methods Mol Biol. 825:151-71, 2012 PMID:22144243
  2. Mukherjee A, Reisdorph N, Guda C, Pandey S, Roy SK. Changes in Ovarian Protein Expression During Primordial Follicle Formation in the Hamster. Mol Cell Endocrinol. 2;348(1):87-94, 2012 PMC: 3418795
  3. Alwis ID, Maroni DM, Hendry IR, Roy SK, May JV, Leavitt WW, Hendry WJ. Neonatal Diethylstilbestrol Exposure Disrupts Ovarian Structure/Function via Both Direct and Indirect Mechanisms in the Hamster. Reproductive Toxicology, 32, 472-483, 2011 PMID: 21963885
  4. Wang C, Roy SK. Expression of E-cadherin and N-cadherin in Perinatal Hamster Ovary: Possible Involvement in Primordial Follicle Formation and Regulation by Follicle-Stimulating Hormone. Endocrinology, 151(5):2319-30, 2010 PMID: 20219978
  5. Sundaram S, Roy SK, Ambati BK, Kompella UB. Surface-functionalized Nanoparticles for Targeted Gene Delivery Across Nasal Respiratory Epithelium. FASEB J, 23(11):3752-65. 2009 PMID: 19608628