George J. Rozanski

George J. Rozanski
Curriculum Vitae

Ph.D. 1981, Loyola University of Chicago
Specialty: Cellular Cardiac Electrophysiology
Major Interest: Cellular basis of bio-electric properties

Ventricular arrhythmias are a major clinical problem contributing to the high incidence of sudden death in chronic disease states that are characterized by a pathophysiological process termed electrical remodeling. The purpose of our research is to explore the cellular and molecular mechanisms of electrical remodeling in experimental models of heart failure such as chronic myocardial infarction and diabetes mellitus. We propose that toxic molecules of oxygen, so-called reactive oxygen species (ROS), inhibit specific, voltage-gated K+ channels in the failing heart, causing abnormal electrical activity, depressed contractile performance, and arrhythmias. We further postulate that cardiac cells normally have endogenous systems that protect and repair the damage to ion channels and other proteins created by ROS. We have found that these repair systems are down-regulated in ventricular myocytes from failing hearts. In our projects, we examine ways to stimulate the activities of these repair mechanisms in myocytes to restore K+ channel activity to normal. Our findings may lead to the development of novel, therapeutic strategies to prevent or reverse cardiac arrhythmias in chronic heart failure.
reactive oxygen species (ROS)

Recent publications

  1. Tang K, Li X, Zheng M-Q, and Rozanski GJ. Role of apoptosis signal- regulating kinase-1-c-Jun NH(2)-terminal kinase-p38 signaling in voltage-gated K+ channel remodeling of the failing heart: Regulation by thioredoxin. Antioxid Redox Signal 14:25-35, 2011. PMID: 20518594
  2. Rozanski GJ. Physiological remodeling of potassium channels in the heart. Cardiovasc Res 93: 218-219, 2012. PMID: 22168994
  3. Shao C-H, Tian C, Ouyang S, Moore CJ, Alomar F, Nemet I, D’Souza A, Nagai R, Kutty S, Rozanski GJ, Ramanadham S, Singh J and Bidasee KR. Cabonylation induces heterogeneity in cardiac ryanodine receptor function during diabetes. Mol Pharmacol 82:383-399, 2012. PMID: 22648972