Saraswathi Viswanathan

Saraswathi Viswanathan, PhD
Curriculum Vitae

Assistant Professor
Ph.D. 1999, University of Madras, Chennai, India
Specialty: Obesity, Type 2 Diabetes, and Cardiovascular Disease
Major Interest: To study the effects of different dietary fatty acids in the presence or absence of cyclooxygenase activity in modulating lipid metabolism in obesity

The overall focus of our laboratory is to determine the link between obesity and cardiovascular disease. Obesity is a growing worldwide concern, and the mechanism by which it leads to other metabolic disorders such as insulin resistance (IR), dyslipidemia, and hepatic steatosis is an area of intense research. Adipose tissue (AT) is a storage reservoir for excess energy in the form of triglycerides (TGs). In addition to storing TGs, AT secretes several factors called adipokines into the plasma which in turn, regulate glucose and lipid metabolism. It is becoming clear that it is not the obesity but the AT-specific inflammation which is more critical in modulating the features of metabolic syndrome. AT-inflammation impairs the storage and secretory functions of AT thereby leading to other metabolic disorders. While COX-derived eicosanoids regulate several physiological and pathological processes, their role in modulating inflammation as it relates to metabolic syndrome is not clear. Our studies are focused on determining the role of cyclooxygenases (COX) in modulating obesity associated cardiovascular risk factors.

  1. Murali G, Milne GL, Webb CD, Stewart AB, McMillan RP, Lyle BC, Hulver MW, Saraswathi V. Fish Oil and Indomethacin in Combination Potently Reduce Dyslipidemia and Hepatic Steatosis in LDLR(-/-) Mice. J Lipid Res. Oct;53(10):2186-97. 2012 PMID: 22847176
  2. Milne, GL., Webb, CD., Stewart AB., Lyle, BC. and Saraswathi, V (2011). A combination of fish oil and indomethacin potently ameliorates dyslipidemia and hepatic steatosis (Manuscript in Revision-Journal of Lipid Research). (no PMID number)
  3. Saraswathi, V., Morrow, JD. and Hasty, AH (2009). Dietary fish oil improves different metabolic variables in lean and obese LDLR-/- mice. J. Nutr. 139, 2380-2386.
  4. Saraswathi, V. and Hasty, AH (2009). Inhibition of long chain acyl coenzyme A synthetases during fatty acid loading induces lipoapoptosis in macrophages. Arterios. Thromb. Vasc. Biol., 29, 1937-1943. PMID: 19679826
  5. Saraswathi, V., Gao, L., Morrow, JD., Chait, A., Niswender, K. and Hasty, AH (2007). Fish Oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr., 137, 1776-1782.  PMID: 17585030