Irving H. Zucker

Irving H. Zucker


Professor and Chair
Ph.D. 1972, New York Medical College
Specialty: Cardiovascular physiology
Major Interest: Neural control of the circulation; angiotensin II; nitric oxide; reactive oxidant stress

Lab page: www.wix.com/izucker/zuckerlab

Curriculum Vitae

Our research focuses on the role of the central brain mechanisms on neurohormonal adjustments in cardiovascular regulation in the setting of experimental chronic heart failure. We are interested in the role of substances such as angiotensin II, nitric oxide and reactive oxidant stress as important mediators of sympathetic excitation in the setting of chronic heart failure. Molecular, cellular and whole animal techniques are used to understand abnormal cardiovascular and neural regulation in heart failure. In addition, we are extremely interested in the role of exercise training in ameliorating some of the abnormalities we have found in the central nervous system of animals with heart failure.

These techniques are providing important new information about normal cardiovascular physiology and about the pathophysiology of heart failure and other cardiovascular diseases.

Students in this laboratory learn surgical preparation of chronically instrumented animals and techniques for measuring a variety of cardiovascular parameters in awake, chronically instrumented animals. Molecular biological techniques such as Western blots, real time RT PCR and histological techniques are routinely used.
Zucker figure

 

  1. Deo, S.H., Fisher, J. P., Vianna, L.C., Kim, A., Chockalingam, A., Zimmerman, M.C., Zucker, I. H., Fadel, P. J. , Statin therapy lowers muscle sympathetic nerve activity and oxidative stress in patients with heart failure. Am. J. Physiol: Heart and Circ Physiol. 303:H377-H385, 2012. PMID: 22661508
  2. Haack, K.K.V, Engler, C. M., Papoutsi, E., Pipinos, I.I., Patel, K.P., Zucker, I.H. Compensatory Role for GRK5 in Neuronal AT1R Expression Following Exercise Training in Heart Failure. Hypertension 60:354-361, 2012. PMID: 22753221
  3. Wang, H-J., Li, Y-L., Zucker, I.H., Wang, W. Exercise training prevents skeletal muscle afferent sensitization in rats with chronic heart failure. Am. J. Physiol. Regu. Integr. Comparative Physiol. 302:R1260-1270, 2012; PMID: 22496362, PMC Journal in Progress.
  4. Haack, K.K.V., Gao, L., Schiller, A.M., Curry, P., Pellegrino, P.R., Zucker, I.H. Central rho kinase inhibition restores baroreflex sensitivity and AT1R protein imbalance in conscious rabbits with chronic heart failure. Hypertension.  61:___, 2013 on-line Jan 2. PMID: 23283363
  5. Wang H.J., Zucker, I.H., Wang, W. Muscle reflex in heart failure: the role of exercise training. Frontiers in Physiol. 3:1-16, 2012.