COORDINATOR

Central States Center for Agricultural Safety and Health (CS-CASH)
Department of Environmental, Agricultural and Occupational Health                                                   
College of Public Health
University of Nebraska Medical Center

Professional Summary

  • 2011-present, Center Coordinator- Central States Center for Agricultural Safety and Health (CS-CASH) Department of Environmental, Agricultural and Occupational Health, UNMC, Omaha, NE
  • 1994-2011, Research Scientist, University of Nebraska Medical Center, Omaha, NE
  • 1990-1994. Scientist II, Atrix Laboratories, Fort Collins, CO

Education

  • 2010, MPH Environmental Health, University of Nebraska Medical Center
  • 1990, BS Microbiology, Colorado State University
  • 1980, AS Equine Science, Scottsdale Community College

Research interests

As Center Coordinator for CS-CASH, I provide the Center Director with assistance in planning, coordinating and monitoring the 23 projects funded by the Center.  These projects encompass research, prevention/intervention, education/translation, outreach, evaluation, and cross-disciplinary efforts.   I engage internal and external advisory committees, oversee fiscal and resource management, maintain records, and compile Center reports.  I serve as the course director for the annual, week-long Agricultural Medicine Course that provides continuing education credits to health care providers across the US. In addition to administrative responsibilities I am involved in the Center’s active Outreach program.  This program delivers educational materials, demonstrations and presentations on the topics of respiratory and hearing protection, as well as injury prevention to the agricultural community in the Center’s seven states region. 

Selected Publications:

  • Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O. (2012) Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.Chem Biol Interact. 2012 Feb 5;195(3):189-98. doi: 10.1016/j.cbi.2011.12.006. Epub 2011 Dec 24.
  • Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O. (2011) Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. Chem Res Toxicol. 2011 Nov 21;24(11):1891-8. doi: 10.1021/tx200237a. Epub 2011 Sep 7.
  • Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O.  (2011)  Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran. Chem Biol Interact. 2012 Feb 5;195(3):189-98. doi: 10.1016/j.cbi.2011.12.006. Epub 2011 Dec 24.
  • Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O. (2011) Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. Chem Res Toxicol. 2011 Nov 21;24(11):1891-8. doi: 10.1021/tx200237a. Epub 2011 Sep 7.
  • Duysen EG, Lockridge O. (2011) Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):214-20. doi: 10.1016/j.taap.2011.06.021. Epub 2011 Jul 2.
  • Duysen EG, Lockridge O. (2011) Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.  Drug Metab Dispos. 2011 Aug;39(8):1321-3. doi: 10.1124/dmd.111.039917. Epub 2011 May 3
  • Duysen EG, Parikh K, Aleti V, Manne V, Lockridge O, Chilukuri N., (2010) Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon.  Gene Ther. Oct 28 [Epub ahead of print]. 
  • Duysen EG, Li B, Lockridge O. (2009) The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert Opin Drug Metab Toxicol. 2009 May;5(5):523-8. Review.PMID: 19416087
  • Duysen EG, Li B, Carlson M, Li YF, Wieseler S, Hinrichs SH, Lockridge O. (2008) Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice. Basic Clin Pharmacol Toxicol. Dec;103(6):514-21.PMID: 19067679
  • Duysen EG, Lockridge O. (2008) Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.  Chem Biol Interact. Sep 25;175(1-3):119-24. Epub 2008 Mar 7.PMID: 18486120

Professional Affiliations

  • Delta Omega Society – Gamma Omicron Chapter
  • UNMC College of Public Health Alumni Association

Contact Ellen Duysen
UNMC College of Public Health
984388 Nebraska Medical Center
Omaha, NE 68198-4388
Phone: 402-522-3394
Email: ellen.duysen@unmc.edu
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