Ghada Soliman, MD, PhD, RD, LMNT

ASSOCIATE PROFESSOR

Graduate Program Director
Department of Health Promotion, Social, and Behavioral Health
University of Nebraska Medical Center
College of Public Health

Professional Summary

  • 2014 – present    Graduate Program Director, Department of Health Promotion, Social, and Behavioral Health, College of Public Health, University of Nebraska Medical Center
  • 2013 – present    Associate Professor, College of Public Health, Department of Health Promotion, Social, and Behavioral Health, University of Nebraska Medical Center
  • 2013 – present  Associate Member, Cancer Prevention and Control Program (CPCP), Eppley Cancer Center, University of Nebraska Medical Center \
  • 2009 - 2012    Assistant Professor, Dietetics and Human Nutrition, College of Education and human Development, Western Michigan University, Kalamazoo, Michigan.
  • 2008 - 2013  Adjunct Research Assistant Professor, Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
  • 2004 - 2008  Research Assistant Professor, Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
  • 2002 - 2004  Assistant Professor, Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, Houston, Texas.
  • 2003 - 2004 Assistant Professor, Graduate Program in Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas.
  • 2000 - 2002  Postdoctoral Fellow, Atherosclerosis, and Vascular Biology Department of Medicine, Baylor College of Medicine, Houston, Texas.
  • 1998 - 2000 Research Associate, Department of Surgery, Baylor College of Medicine, Houston, Texas.
  • 1996 - 1998 USDA-Postdoctoral Fellow, Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
  • 1994 - 1995 Postdoctoral Research Associate, Nutritional Sciences, Lipid Metabolism Laboratory, University of Arizona, Tucson, Arizona
  • 1991 - 1994 Graduate Research Assistant, Nutritional Sciences, Lipid Metabolism Laboratory, University of Arizona, Tucson, Arizona
  • 1990 - 1991 Graduate Research Assistant, Department of Family and Community Medicine, University of Arizona, Tucson, Arizona

Education

  • MD Cairo University Medical School, Cairo, Egypt 1987
  • PhD Nutritional Sciences, University of Arizona, Tucson, AZ, 1994
  • Postdoctoral Fellowship, Baylor College of Medicine, Children’s Nutrition Research Center, and Atherosclerosis and Vascular Biology, 1996-2002.
  • Dietetic Internship, University of Michigan Hospitals and Health Centers, Ann Arbor, Michigan 2008-2009
  • Certificate of Training in Adult Weight Management, Commission on Dietetic Registration, (Level I) 2010, (Level II) 2011.
  • Certificate of Training in Childhood and Adolescent Weight Management, Commission on Dietetic Registration, 2013.

Research Interests
Dr. Soliman’s academic agenda is centered on optimal nutrition as an integral part of global health promotion and disease prevention; and the public health and social burdens of malnutrition. This umbrella of malnutrition encompasses both overnutrition (obesity and metabolic–related diseases), and undernutrition (macronutrient and micronutrient deficiencies, and eating disorders). 

Dr. Soliman’s translational research is focused on obesity, and related metabolic disorders, as well as the impact of micronutrient deficiencies among individuals, across populations, and globally.  To promote optimal health, the comprehensive weight management collaborative research program emphasizes nutritious well-balanced diet, physical activity, and behavioral modification to achieve and sustain weight loss and weight maintenance.

Dr. Soliman’s basic laboratory based research focuses on a nutrient-sensing protein termed the mammalian Target of Rapamycin (mTOR), as a master regulator of metabolism, cell growth, and proliferation. Deregulation of the mTOR signaling pathway has been implicated in the pathogenesis of several chronic diseases including insulin resistance, diabetes, metabolic syndrome, and cancer development and progression.

Selected Publications

  • Soliman GA. The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses, Nutrients, 2013: 5: 2231-2257.

  • Schiefelbein EL, Zekri A, Newton D, Soliman GA, Banerjee M, Hung C-W, Iyer P, Seifeldin IA, Ramadan M, Lo A, Soliman AS. Hepatitis C and other risk factors in hepatocellular carcinoma. Acta Virologica 2012; 56(3):235-40. 2012.
  • Soliman GA. The Integral Role of mTOR in Lipid Metabolism. Cell Cycle. Volume 10, Issue 6: 861 – 862, 2011.
  • Soliman GA, Acosta-Jaquez H, and DC. Fingar.  mTOR inhibition via rapamycin promotes triacylglycerol lipolysis and release free fatty acids in 3T3-L1 adipocytes, Lipids 2010, 45: 1089-100.
  • Soliman GA, Acosta-Jaquez H, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. mTOR S2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem. 2010 Mar 12; 285(11):7866-79.
  • Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Regulation of mTOR complex 1 (mTORC1) by raptor S863 and multi-site.       J Biol Chem. 2010 Jan 1; 285(1):80-94.
  • Acosta-Jaquez H, Keller J, Foster K, Ekim B,  Soliman GA, Ballif BA, and Fingar DC. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol. 2009 Aug; 29(15):4308-24.
  • GA Soliman, R Ishida-Takahashi, Y Gong, T Saunders, DC Fingar, and MG Myers, Jr.  A simple qPCR-based method to detect correct insertion of homologous targeting vectors in embryonic stem cells. Transgenic Research 2007 Oct; 16(5):665-70.
  • Aggarwal D, Hedley CF, Soliman GA,  Dutta A, and Fernandez ML. Validation of gene expression In peripheral mononuclear cells as marker of hepatic cholesterol metabolism in guinea pigs. Lipids in Health and Disease, 2006 Aug 15; 5:22.
  • Aggarwal D, Fernandez ML, and Soliman GA. Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs. Metabolism, 2006 Jun; 55(6):794-802.
  • Soliman GA. The mTOR signaling network and gene regulation. Current Opinion in Lipidology, 2005, June; 16:317-323.

Professional Affiliations

  • American Society on Nutritional Sciences (ASN)
  • American Diabetes Association, Member (ADA)
  • American Public Health Association (APHA)
  • Nebraska Academy of Nutrition and Dietetics (NAND)
  • The Obesity Society
  • Academy of Nutrition and Dietetics
  • Metabolomics Society
  • Weight Management Dietetic Practice Group
  • Research in Dietetics Practice Group (RDPG)
  • Dietetics Practice Group, Nutrition Educators of Health Professional,
  • Michigan Academy of Nutrition and Dietetics (MAND),
  • Ad hoc Reviewer, Journal of Nutrition, Obesity Research, Kidney International, Journal of Nutritional Biochemistry, Journal of Pharmacology and Experimental Therapeutics, Arthritis Research and Therapy, Gene, Lipids, and Molecular and Cellular Endocrinology.

Contact Ghada Soliman
Ghada Soliman, MD, PhD, RD, LMNT

984365 Nebraska Medical Center
Omaha, NE 68198-4365
Phone: (402)559-5157
Fax: (402) 559-3773
email: ghada.soliman@unmc.edu

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