Professor

Environmental, Agricultural and Occupational Health
College of Public Health
Professor, Internal Medicine
Division of Pulmonary, Critical Care, Sleep & Allergy
College of Medicine
University of Nebraska Medical Center

Professional Summary

  • 2011-Present  Professor, Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE USA
  • 2008-Present Professor, Department of Internal Medicine, Division of Pulmonary, Critical Care, Sleep & Allergy, College of Medicine, University of Nebraska Medical Center, Omaha, NE USA
  • 2008-2011  Associate Professor, Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE USA
  • 2003-2008  Associate Professor, Department of Internal Medicine, Division of Pulmonary, Critical Care, Sleep & Allergy, College of Medicine, University of Nebraska Medical Center, Omaha, NE USA
  • 1997-2003  Assistant Professor, Department of Internal Medicine, Division of Pulmonary, Critical Care, Sleep & Allergy Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE USA
  • 1995-Present  Research Biochemist, Research Service, Department of Veterans Affairs, Omaha, NE USA
  • 1995-1997  Instructor, Department of Internal Medicine, Division of Pulmonary, Critical Care, Sleep & Allergy, College of Medicine, University of Nebraska Medical Center, Omaha, NE USA
  • 1992-1995  Postdoctoral Research Associate, Supervisor: Jackie D. Corbin, PhD, Vanderbilt University Medical Center, Nashville, TN USA
  • 1988-1992  Graduate Student, Katherine B. Pryzwansky, PhD, dissertation advisor, University of North Carolina, Chapel Hill, NC USA

Education

  • PhD University of North Carolina, Chapel Hill, NC, 1992
  • BS Vanderbilt University, Nashville, TN, 1986


Research Interests

The research in my laboratory is directed toward the understanding of airway epithelial cell function under physiologic and disease conditions. We are interested in the mechanistic signal transduction pathways that define ciliary beating, pro-inflammatory cytokine production, remodeling and wound repair, and cell adhesion under conditions of cigarette smoking and alcohol consumption. Our studies aim to define the role of serine-threonine protein kinases and the second messengers that regulate these enzymes in lung epithelial function.  I received the American Lung Association Career Investigator Award. I was awarded the Distinguished Scientist Award here at UNMC in 2010 and in 2012. I received the Department of Veteran’s Affairs Research Career Scientist Award in 2012. 

Selected Publications

  • Wyatt, T. A., J. H. Sisson, D. S. Allen-Gipson, M. L. McCaskill and J. A. Poole. Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner. Am. J. Pathol. 181:431-440, 2012.
  • Poole, J. A., D. J. Romberger, C. Bauer, A. M. Gleason, J. H. Sisson, P. Oldenburg, W. W. W. West, and T. A. Wyatt. Protein Kinase C epsilon is Important in Modulating Organic Dust-Induced Airway Inflammation. Exp. Lung Research 38:383-95, 2012.
  • McCaskill, M. L., D. J. Romberger, K. L. Bailey, J. A. Poole and T. A. Wyatt. Alcohol exposure alters mouse lung inflammation in response to inhaled dust. Nutrients 4:695-710, 2012.
  • Bailey, K. L., Yanov, D. A., T. D. LeVan, J. H. Sisson, J. M. DeVasure, J. A. Pavlik, and T. A. Wyatt. Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase C epsilon. Respir Res 13:49-56, 2012.
  • Golden, G. A., T. A. Wyatt, D. J. Romberger, D. Reiff, M. L. McCaskill, C. Bauer, A. M. Gleason, J. A. Poole. Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences. J. Biochem. Mol. Toxicol. 27(1):77-86, 2013.
  • Bauer, C., T. Kielian, T. A. Wyatt, W. W. West, A. M. Gleason, D. J. Romberger, and J. A. Poole. MyD88-dependent pathway is critical to acute organic dust-induced airway inflammation in mice. Am. J. Respir. Mol. Cell Biol. 48:781-789, 2013.
  • Wyatt, T. A. and J. H. Sisson. Alcohol, the upper airway, and mucociliary dysfunction in the conducting airways. In Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach, Edited by D. M. Guidot and A. J. Mehta, Springer-Verlag New York, ISBN 146148832X, 2013.
  • Allen-Gipson, D. S., M. C. Zimmerman, H. Zhang, J. K. O’Malley, H. Alvarez-Ramirez, K. Kharbanda, J. H. Sisson, and T. A. Wyatt. Smoke Extract Impairs Adenosine Wound Healing: Implications of Smoke-Generated Reactive Oxygen Species. Am. J. Respir. Mol. Cell Biol. 48:665-673, 2013.
  • Zheng, M.-Q., X. Li, L. Gao, T. A. Wyatt, K. Tang, N. Sharma, K. P. Patel, G. J. Rozanski. Pyruvate Restores β-Adrenergic Sensitivity of L-type Ca2+ Channels in Failing Rat Heart: Role of Protein Phosphatase. Am. J. Physiology-Heart 304:H1352-H1360, 2013.
  • Nordgren, T. M., A. J. Heires, T. A. Wyatt, J. A. Poole, T. D. LeVan, D. R. Cerutis, and D. J. Romberger. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. Respiratory Research 14:51-60, 2013.

Professional Affiliations

  • American Thoracic Society (ATS)
  • American Society for Cell Biology (ASCB)
  • Society for Leukocyte Biology (SLB)
  • Society for Experimental Biology and Medicine (SEBM)
  • Sigma Xi
  • American Society for Investigative Pathology (ASIP)
  • International Society for Biomedical research in Alcoholism (ISBRA)
  • Research Society on Alcoholism (RSA)

contact todd wyatt

984388 Nebraska Medical Center
Omaha, NE 68198-4388
Phone: (402) 559-3817
Email: twyatt@unmc.edu
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