Immune Reactivity in Dibenzo (a,l) Pyrene Carcinogenesis, NE DHHS - LB506, George Casale, July 1, 1998-June 30, 1999.

Inhibition of DNA Replications by Antimetabolites, NE DHHS-LB506, William Gmeiner, July 1, 1998-June 30, 1999.

Regulation of Apoptosis by Ras Effectors, NE DHHS-LB506, Robert Lewis, July 1, 1998-June 30, 1999.

Inhibition of the Type II TGF-B-Receptor Gene, NE DHHS-LB506, Angie Rizzino, July 1, 1998-June 30, 1999.

C5a and Airway Epithelium in Smoking- Induced Inflammation, ALA-National, Sam Sanderson, July 1, 1998-June 1, 1999.

Alveolar Basement Membrane/Cell Interactions in the Lung, North Carolina State University, Pi-Wan Cheng, biochemistry/molecular biology, Sept. 1, 1997-Aug. 30, 1998.

Diabetes Prevention Trial - Type 1 (DPT-1), Operations Coordinating Center; University of Miami School of Medicine, James Lane, internal medicine, April 1, 1998-March 31, 1999.

Multicenter Study to Evaluate the Safety and Efficacy of Levofloxacin 500mg, Once Daily in the Treatment of Community-Acquired Pneumonia in Adults, Quintiles BRI, Inc., Stephen Rennard, internal medicine, Jan. 23, 1998-Sept 30, 1999.

Phase III Trial of CHOP Alone for Newly Diagnosed Agressive Non-Hodgkin’s Lymphoma, Genetech, Inc., Julie Vose, internal medicine, March 1, 1998-Dec. 31, 1999.

Phase 2 Evaluation of ALRT1057 (9-cis-Retinoic Acid) Capsules in Patients with Advanced Ovarian Cancer Resistant to Carboplatin, Ligand Pharmaceuticals Incorporated, McClure Smith, obstetrics/gynocology, Nov. 30, 1997-Nov. 30, 1998.

Unoprostone Isopropyl Mechanism of Action, CIBA Vision Corporation, Michael Yablonski, ophthalmology, April 13, 1998-March 31, 1999.

Defining Toxicity and Benefit for Radioimmunotherapy, Novopharm Biotech, Inc., David Colcher, pathology/microbiology, Feb. 1, 1998-Jan. 31, 1999.

Liver Transplant Study Contract, University of Minnesota, Rodney Markin, pathology/microbiology, Sept. 1, 1997-Aug. 31, 1998.

Antigenicity of Proteins Modified by Alcohol Metabolites, DHHS/NIH/NIAAA, Monte Willis, pathology/microbiology, April 1, 1998-March 31, 1999.

Furosemide Treatment: Effects on Glomerulosclerosis and Transforming Growth Factor Beta in Normal and Nephrectomized Rats, AHA— National, Pascale Lane, pediatrics Feb. 1, 1998-June 30, 1998.

A Phase II Study of Amifostine in Patients with Myelodysplastic Syndrome, U.S.Bioscience, Inc., Michael Bishop, internal medicine, March 1, 1998-July 31, 1998.

CALGB Cooperative Group Outreach Program, University of Chicago, Margaret Kessinger, internal medicine, April 1, 1997-March 31, 1998.

Alcon Monkey Study, Alcon Laboratories, Carl Camras, ophthalmology, Jan. 1, 1998-Dec. 31, 1998.

Diagnostic and Prognostic Significance of Genetic Markers in Common Pediatric Soft Tissue Sarcomas, Children’s Hospital Foundation, Julia Ann Bridge, pathology/microbiology, Jan. 1, 1998-Dec. 31, 1998.

Children's Cancer Group Chairman's Award, National Childhood Cancer Foundation, Peter Coccia, pediatrics, Dec. 1, 1997-Nov. 30, 1998.

IPA for Erik Gamerl, V.A. Medical Center — Omaha, Timothy Baxter, surgery, May 11, 1998-Sept. 30, 1998.

Effect of Proteases on Airway Mucin Glycosylation, ALA — Nebraska, Paul Beum, biochemistry/molecular biology, July 1, 1998-June 30, 1999.

Development of Gene Transfer Vectors for Targeting Lung Cancer Cells, NE DHHS - LB506, Pi-wan Cheng, biochemistry/molecular biology, July 1, 1998-June 30, 1999.

Role of CD9 in Breast Cancer Progression, NE DHHS — LB506, Judith Christman, biochemistry/molecular biology, July 1, 1998-June 30, 1999

Tumor Suppressor Gene FHIT in Breast Cancer, NE DHHS — LB506, J.K. Vishwanatha, biochemistry/molecular biology, July 1, 1998-June 30, 1999.

Determinants of Immunosuppressive Molecular From Lymphoma, NE DHHS -LB506, Shantaram Joshi, cell biology &anatomy, July 1, 1998-June 30, 1999.

Induction of Apoptosis in Ethanol-Fed Rats, Alcoholic Beverage Medical Research Foundation, Carol Casey, internal medicine, July 1, 1998-June 30, 1999.

A Multicenter, Double-Blind, Placebo-Controlled Study of Filgrastim in the Treatment of Patients with Pneumonia and Severe Sepsis, Amgen Inc., Craig Piquette, internal medicine, April 1, 1998-Dec. 31, 1998.

Smoking Cessation in Outpatient Alcohol Abuse Treatment, NE DHHS-LB506, Debra Romberger, internal medicine, July 1, 1998-June 30, 1999.

Chemoprevention of Esophageal Adenocarcinoma with NSAIDS: Modulation of Apoptosis and Proliferation via Protein Kinase C, Glaxo Wellcome, Roy Hemant, internal medicine, July 1, 1998-June 30, 1999.

Pilot Study of the Influence of nelfinavir on HIV in Privileged Sites, Agouron Pharmaceuticals, Inc., Susan Swindells, internal medicine, June 1, 1998-May 31, 1999.

A Phase 3 Open Label, Randomized, Controlled Study in Subjects with Poor Prognosis Acute Myelogenous Leukemia Randomized to SDZ PSC 833 & Cytarabine, Mitoxantrone and Etoposide (AME) or AME Alone, Novartis Pharmaceuticals Corporation, Stefano Tarantolo, internal medicine, May 15, 1998-March 31, 1999.

A Phase 3 Study of PSC 833 in Combination with Paclitaxel and Carboplatin (PC-PSC) Versus Paclitaxel and Carboplatin (PC) Alone in Patients with Stage IV or Suboptimally Debulked Stage III Epithelial Ovarian Cancer or Primary Cancer of the Peritoneum, Novartis Pharmaceuticals Corporation, David McIntosh, obstetrics/ gynocology, Feb. 2, 1998-March 19, 1999.

AIDS Related Neurotoxins: g120 and NMDA Antagonists, Brigham and Women’s Hospital, Howard Gendelman, pathology/microbiology, Aug. 1, 1997-Jan. 31, 1998.

Multiple Contracts with Abbott Labs, Abbott Laboratories, Mary Haven, pathology/microbiology, Feb. 9, 1998-Feb 9, 1999.

Universal Swab Equivalency Study, Gen-Probe Inorporated, Peter Iwen, pathology/microbiology, March 1, 1998-Feb. 28, 1999.

BCR/ABI. Positivity of Early Stem Cells from CML Patients, NE DHHS - LB506, John Jackson, pathology/microbiology, July 1, 1998-June 30, 1999.

Dominant Negative Proteins for Leukemia Therapy, NE DHHS — LB506, Paul Stemmer, pediatrics, July 1, 1998-June 30, 1999.

PDGF Regulated Signal Transduction by vav2, NE DHHS - LB506, Rodney Kawahara, pharmacology, July 1, 1998-June 30, 1999.

Exercise and Sympathetic Nerve Activity in Heart Failure, AHA — Nebraska Jun-Li Liu, physiology & biophysics, July 1, 1998-June 30, 1999.

Effect of Exercise Training on Chemoreflex Function in Heart Failure: Role of Nitric Oxide, AHA - Nebraska, Shu-Yu Sun, physiology & biophysics, July 1, 1998-June 30, 1999.

An Epidemiologic Evaluation of PSA and Prostrate Cancer, NE DHHS - LB506, Brian Chiu, preventive & societal medicine, July 1, 1998-June 30, 1999.

Pharmacokinetic and Pharmacokynamic Data Analysis, Searle,Pharmaco, Roxane Labs, Thomas Ludden, pharmaceutical science, Jan. 1, 1998-Dec. 31, 1998.

Thermodynamics of DNA Conformation and Interactions, DHHS/NIH/NIGMS, Luis Marky, pharmaceutical science, Sept. 1, 1997-Aug. 31, 1998.

Delivery of Protease Inhibitors to the Brain Utilizing Inhibitory Drugs of the Efflux Pump P-glycoprotein, PhRMA Foyndation, Timothy Spitzenberger, pharmaceutical science, July 1, 1998-June 30, 2000.

Massage and Healing Touch: Effects on Caregivers of HSCT Patients, Oncology Nursing Society, Stephanie Rexilius, administration/LRC, May 1, 1998-April 30, 1999.

Breast Cancer Survivors: A Qualitative Study, Oncology Nursing Society, Cecilia Barron, gerontological, psychosocial, and community health, May 1, 1998-April 30, 1999.

Risk Factors and Health Status of Participants and Nonparticipants in Cardiac Rehabilitation, Good Samaritan Hospital Foundation, Bernice Yates, RHN/WENE/Kearney, Feb. 1, 1998-Jan. 31, 1999.

NASA Nebraska Space Grant Consortium, University of Nebraska - Omaha, Lynne Farr, administration/LRC, March 1, 1998-Feb. 28, 1999.

Effects of Estrogen on Human Macrophage LPS Receptors, American Association Dental Research, Chad Meyer, surgical specialties, July 1, 1998-June 30, 1999.

A Preliminary Assessment of SIS to Promote Regeneration of Masticatory Mucosa, Alveolar Bone and Tooth Dentin in Dogs, Cook Biotech, Inc., Mark Beatty, adult restorative, March 15, 1998-Dec. 31, 1998.

Concentrations and Distribution of IL-1, IL -6, TNF, and TGF Cytokines During Orthodontic Tooth Movement, American Association of Orthodontists Foundation, Jeffrey Nickel, growth and development, July 1, 1998-June 30, 1999.

Molecular Origin of Cancer PAH to Estrogen Quinones,DHHS/NIH/NCI, Ercole Cavalieri, May 1, 1998-April 30, 1999.

Rapid Detoxification of Cocaine by Butyrylcholinesterase, DHHS/NIH/NIDA, Oksana Lockridge, April 1, 1998-March 31, 1999.

Nonvolatile N-Nitroso Compounds in Foods/Gastric Juice, DHHS/NIH/NCI, Sidney Mirvish, May 1, 1998-April 30, 1999.

Structure and Function of C5a Agonist Molecular Adjuvants, Ribi Immunochem Research, Inc., Sam Sanderson, March 9, 1998-March 31, 1999.

Genetic Susceptibility to Estrogen-Induced Mammary CA, DHHS/NIH, James Shull, April 1, 1998-Jan. 31, 1999.

Spore in Gastrointestinal Cancer, DHHS/NIH/NCI, Margaret Tempero, May 15, 1998-Jan. 31, 1999.

Molecular Origin of Cancer PA11 to Estrogen Quinones, DHHS/NIH/NCI, Ercole Cavalieri, May 1, 1998-April 30, 1999.

Activation and Transportation of Nitrosamines, DHHS/NIH/NCI, Barry Gold, June 1, 1998-May 31, 1999.

Molecular Analysis of Mucin Type O Glycosylation, DHHS/NIH/NCI,Michael Hollingsworth, June 1, 1998-May 31,1999.

Correction of Looped DNA Mismatches in Yeast, ACS — National, Robert Lahue,July 1, 1998-June 30, 1999.

Acetyltransferase and Diet as Determinants of Cancer, American Institute for Cancer Research, Terence Lawson, July 1, 1998-June 30, 1999.

Anti-Apoptic Signaling Pathways, ACS - National, Robert Lewis, July 1, 1998-June 30, 1999.

LB595 Tobacco Tax Cancer Research, LB595 — NE DHHS, Margaret Tempero, July 1, 1998-June 30, 1999.

Steroid Regulation of Human Prostate Cancer Cells, DHHS/NIH/NCI, Ming-Fong Lin, biochemistry/molecular biology, May 1, 1998-April 30, 1999.

Ethanol Effects on Proteolytic Systems in the Liver, DHHS/NIH/NIAAA, Terence Donohue, internal medicine, April 1, 1998-March 31, 1999.

Safety and Efficacy of Fixed Combination Metformin/Glyburide Products as First Line Therapy in Patients with Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control with Diet and Exercise, Bristol-Meyers Squibb, Jennifer Larsen, internal medicine, April 1, 1998-March 31, 1999.

Neuropharmacology of HIV Dementia, DHHS/NIH/NIMH, Jenae Limoges, internal medicine, May 1, 1998-Feb. 28, 1999.

A Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of R108512 Tablets in Subjects with Chronic Constipation, Janssen Pharmaceutica Inc., Eamonn Quigley, internal medicine, March 1, 1998-Feb. 28, 1999.

Ethanol and Acetaldehyde-Altered Ciliary Motility, DHHS/NIH/NIAAA,Joseph Sisson, internal medicine, April 1, 1998-March 31, 1999.

A Phase III, Multicenter, Randomized, Open-Label Study to Compare Antiretroviral Activity & Tolerability of 3 Different Combination Regimens (DMP 266+Indinavir, DMP 266+Zidovudine + Lamivudine,Indinavir + Zidovudine + Lamivudine) in HIV-Infected Patients, The DuPont Merck Pramaceutical Company, Susan Swindells, internal medicine, April 19, 1998-March 31, 1999.

Evaluation of the Mode of Action and Dose Response of Cacodylic Acid on the Urinary Bladder Following Administration to Rats, Luxembourg Industries(Pamol) Inc., Samuel Cohen, pathology/microbiology, March 1, 1998-Dec. 31, 1998.

Neuronal Electrophysiology in HIV Dementia, DHHS/NIH/NINDS, Howard Gendelman, pathology/microbiology, April 1, 1998-March 31, 1999

Molecular Mechanisms of HIV Dementia, DHHS/NIH/NINDS, Howard Gendelman, pathology/microbiology, April 1, 1998-March 31, 1999.

Phase II Trial: Treatment of PTLD in Organ Transplant, DHHS/NIH, Thomas Gross, pathology/microbiology, April 1, 1998-March 31, 1999.

A Collaborative Study of Usher Syndrome, Father Flanagan's Boys' Home, Janos Sumegi, pathology/microbiology, Dec. 1, 1997-Nov. 30, 1998.

Mechanism of Regulation of a Glomerular K Channel, DHHS/NIH/NIDDK, Steven Sansom, physiology & biophysics, May 1, 1998-April 30, 1999.

Defining Toxicity and Benefit For Radioimmunotherapy, Novopharm Biotech, Inc., Janina Baranowska-Kortylewicz, radiation oncology, Feb. 1, 1998-Jan. 31, 1999.

A Double-Blind, Placebo Controlled, Multicenter Study to Evaluate the Efficacy and Safety of a Single Intravenous Dose of CP-101,606 in Subjects with Severe Head Injury, Pfizer Inc., Bizhan Aarabi, surgery, March 18, 1998-March 17, 1999.

A Comparative Study of the Effect and Equivalence of Sirolimus Oral Liquid Versus Sirolimus Tablets, Administered Concomitantly with Cyclosporine and Corticosteroids in Renal Allograft Recipients, Wyeth-Ayerst Research, Rodney Taylor, surgery, March 1, 1998-June 30, 1999.

Development and Migration of LHRH Neurons in the chick, DHHS/NIH/NINS,Robert Norgren, cell biology and anatomy, April 4, 1998-March 31, 1999.

A Prospective, Multinational, Multicenter, Double-Blind, Randomized, Active-Controlled Trial in Patients with Essential Hypertension to Compare the Effect of Valsartan 80 and 160 mg with or without the Addition of Hydrochlorothiazide, Once Daily, Novartis Pharmaceuticals Corporation, Gay Canaris, internal medicine, Feb. 2, 1998-Feb. 1, 1999.

Ethanol Effect on Endocytosis in Liver, DHHS/NIH/NIAAA, Carol Casey, internal medicine, May 1, 1998-April 30, 1999.

A Multicenter Evaluation of the Effects of Zyban (bupropion hydrochloride sustained release tablets) Versus Placebo in a Population of Smokers with COPD, Glaxo Wellcome Inc., Stephen Rennard, internal medicine, March 9, 1998-March 8, 1999.

Chloride Regulation of Photoreceptor Neurotransmission, DHHS/NIH/NEI, Wallace Thoreson, ophthalmology, June 1, 1998-May 31, 1999.

Bone Marrow Purging with SCH58500: A Feasibility Study & Protocol for Studies on the Engraftment and Development of Adv Infected Human CD34+ Enriched Cells from PSC Products in NOD/LtSz-scid Mice, Canji, Inc., James Talmadge, pathology/microbiology, Oct. 8, 1996-Oct. 7, 1998.

Intergroup Rhabdomyosarcoma Study, DHHS/NIH/NCI, Harold Maurer, pediatrics, Jan. 1, 1998-Dec. 31, 1998.

Arsenic Toxicity and Peturbations of DNA Methylation,DHHS/NIH/NIEHS, Roseann Vorce, pharmacology, May 1, 1998-April 30, 1999.

Intergroup Rhabdomyosarcoma Study Statistical Center, National Childhood Cancer Foundation, James Anderson, preventive & societal medicine, Jan. 1, 1998-Dec. 31, 1998.

Molecular Studies on MUC4 Mucin Gene, DHHS/NIH/NCI, Surinder Batra, biochemistry/molecular biology, July 1, 1998-April 30, 1999.

Doexyribonucleotide Inhibitors of DNA Methyltransferase as Diagnostic/Therapeutic Agents for Breast Cancer, Susan G. Komen Foundation-Omaha Affiliate, Judith Christman, biochemistry/molecular biology, Dec. 1, 1997-Dec. 1, 1998.

Genetic Investigation of Lammer Protein Kinase Structure and Function in Drosophila, NSF, Leonard Rabinow, biochemistry/molecular biology, Sept. 1, 1997-Aug. 31, 1999.

A Comparison of Granulocyte Colony-Stimulating Factor (G-CSF) with the Combination of G-CSF and Granulocyte-Macrophage Colony Stimulating Factor(GM-CSF) for the Mobilization of Progenitor Cells and Dendritic Cells in Normal Individuals, Immunex Corporation, Michael Bishop, internal medicine, April 1, 1998-March 31, 1999.

Growth Factors in Follicular Development, DHHS/NIH/NICHHD, Shyamal Roy, obstetrics/gynecology, June 1, 1998-May 31, 1999.

A Twelve-Month, Triple-Masked, Parallel Group, Primary Therapy Study of the Safety and Efficacy of AL-6221 0.0015% and AL-62210.004% Compared to TIMPOTIC 0.5% and XALATAN 0.005% in Patients with Open-Angle Glaucoma or Ocular Hpertension, Alcon Laboratories, Inc., Carl Camras, ophthalmology, June 8, 1998-June 7, 1999.

Radio-Labeling Research, Coulter Pharmaceutical, Inc., David Colcher, pathology/microbiology, April 30, 1998-April 30, 1999.

Molecular Mechanisms of IIIV-Mediated Encephaeopathy, St. Luke’s-Roosevelt Institute for Health Sciences, Howard Gendelman, pathology/microbiology, May 1, 1998-April 30, 1999.

Animal/Fetal Tissue Core, St. Luke’s-Roosevelt Institute for Health Sciences, Howard Gendelman, pathology/microbiology, May 1, 1998-April 30, 1999.

A Molecular Risk Assessment Panel Predicts Increased Risk for Metastases, ACS - National, Monica Traystman, pathology/microbiology, July 1, 1998-June 30, 1999.

Molecular Studies on Intestinal Mucin and Its Function, DHHS/NIH/NIDDK, David Mack, pediatrics, May 22, 1998-April 30, 1999.

Intergroup Rhabdomyosarcoma Study, DHHS/NIH/NCI, Harold Maurer, pediatrics, Jan. 1, 1998-Dec. 31, 1998.

Effect of Nicotine in Microvascular Dysfunction, Smokeless Tobacco Research Council, Inc., William Mayhan, physiology & biophysics, July 1, 1998-June 30, 1999.

Volume Regulation in Diabetes: Intrarenal Mechanisms, ADA - National, Kaushik Patel, physiology & biophysics, July 1, 1998-June 30, 1999.

Cardiac Afferents, Free Radicals, and Ischemia, DHHS/NIH/NHLBI, Harold Schultz, physiology & biophysics, Aug. 1, 1998-July 31, 1999.

Inflammation and Matrix Metabolism in Aortic Aneurysms, DHHS/NIH/NHLBI, Timothy Baxter, surgery, June 1, 1998-May 31, 1999.

A Phase III, Randomized, Double-Blind, Placebo Controlled Multicenter Study of the Efficacy of Odulimomab (ANTILFA) in Preventing Delayed Graft Function (DGF) of Cadaveric Allografts in Patients Not Receiving Biological Induction Immunosuppressive Therapy, IMTIX - Pasteur Merieux Connaught Transplantation, Rodney Taylor, surgery, May 1, 1998-Dec. 31, 1998.

Genetic Testing for Cancer Risk: Psychosocial Impact, DHHS/NIH/NINR, Julia Houfek, gerontological, psychosocial, and community health, June 1, 1998-May 31, 1999.

MRP-Mediated Drug Transport in the BBB, DHHS/NIH/NCI, William Elmquist, pharmaceutical science, Jan. 1, 1998-Dec. 31, 1998.

Water Soluble Block Ionomer Complexes, NSF, Alexander Kabanov, pharmaceutical science, June 1, 1998-May 31, 1999.

Biodegradable Sustained Release Nanoparticles for Restinosis, DHHS/NIH/NHLBI, Vinod Labhasetwar, pharmaceutical science, June 1, 1998-May 31, 1999.

Effects of TNFGamma on Blood-Brain Barrier Permeability, DHHS/NIH/NINDS, Donald Miller, pharmaceutical science, May 2, 1998-May 1, 1999.