Michael Douglas Boska, PhD

Professor and Vice Chairman Radiology Research

Education:  

• PhD: Biophysical Chemistry, University of California, Berkeley 

Research Interests:

• Bioimaging Core Facility
• Center for Drug Delivery and Nanomedicine
• Center for Neurodegenerative Disorders
• Center for Integrative and Translational Neuroscience
• Proteomic Strategies for AIDS and Drug Abuse - HIV and METH CNS Synergy
• Chronic HIV infection and Aging in NeuroAIDS (CHAIN)
• Neural Immunity in HIV Dementia
• Nebraska Center for Nanomedicine

Publications:

1. Boska MD, Lewis TB, Destache C, Benner EJ, Nelson JA, Uberti M, Mosley RL,  Gendelman HE: Quantitative 1H Magnetic Resonance Spectroscopic Imaging Determines Therapeutic Immunization Efficacy in an Animal Model of Parkinson’s Disease, J Neurosci, 25:1691-1700, 2005.
2. Boska M, Hasan K, Kibuule D, Banerjee R, McIntyre E, Nelson J, Hahn T, Gendelman HE, Mosley RL. Quantitative Diffusion Tensor Imaging Detects Dopaminergic Neuronal Degeneration in a Murine Model of Parkinson's Disease. Neurobiology of Disease 26(3):590-596, 2007.  PMCID: 2040046
3. Liu Y, Uberti MG, Dou H, Banerjee R, Grotepas CB, Stone DK, Rabinow BE, Gendelman HE, Boska MD. Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis.  J Neuroimmunol 200:41-52, 2008. PMCID 2629545
4. Beduneau A, Ma Z, Grotepas CB, Kabanov A, Rabinow BE, Gong N, Mosley RL, Dou H, Boska MD, Gendelman HE. Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparaticles. PLoS ONE. 4(2):e4343. Epub 2009 Feb 2.
5. Uberti M, Boska MD, Liu Y. A Semi-automatic image segmentation method for extraction of brain volume from in vivo mouse head magnetic resonance imaging using Contraint Level Sets. J Neurosci Methods 2009:179;338-344.
6. Liu Y, Uberti M, Mosley RL, Gendelman HE, Boska M. An image waping technique for rodent brain MRI-histology registration based on thin-plate splines with landmark optimization. Proc SPIE Med Imaging. 2009 Volume 7259.
7. Uberti M, Liu Y, Dou H, Mosley RL, Gendelman HE, Boska M. Registration of in vivo MR to histology of rodent brains using blockface imaging. Proc SPIE Med Imaging 2009; Volume 7262.
8. Batrakova EV, Gendelman HE, Kabanov AV, Li S, Brynskikh AM, Sharma AK, Li Y, Boska M, Gong N, Mosley RL, Alakhov VY. Effects of Pluronic and Doxorubicin on Drug Uptake, Cellular Metabolism, Apoptosis and Tumor Inhibition in Animal Models of MDR Cancers. J Control Release. 2010.
9. Brynskikh AM, Zhao Y, Mosley RL, Li S, Boska MD, Klyachko NL, Kabanov AV, Gendelman HE, Batrakova EV. Macrophage delivery of therapeutic nanozymes in a murine model of Parkinsons disease. Nanomedicine (Lond).  2010; 5(3) : 379-96.  PMCID: PMC2880389
10. Quan LD, Wang D, Purdue PE, Liu XM, Boska MD, Lele SM, Thiele GM, Mikuls TR, Dou H, Goldring SR. Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and su sustained therapeutic efficacy.  Arthritis Res Th. 2010; 12(5) : R170. PMC PMCID 2990997
11. Dash, PK, Gorantla, S, Gendelman, HE, Knibbe, J, Casale, GP, Makarov, E, Epstein, AA, Gelbard, HA, Boska, MD, Poluektova, LY, Neuroscience, 2011, 31:3148-3157.