Bone & Cartilage

Andrew T. Dudley, Ph.D.
Assistant Professor, Genetics Cell Biology & Anatomy
Special Scientist, Regenerative Medicine

Dr. Dudley's laboratory studies the musculoskeletal system and how it develops. The extracellular matrix of bone and cartilage is their basic functional unit, whereas in other tissues, the cells themselves are the basic functional unit. They study how the extracellular matrix develops so that bone and cartilage can form appropriately.  “Establishing the infrastructure of the matrix as well as the cellular component is necessary/critical as we look to understand how the regeneration processes can be applied to the musculoskeletal system."  Projects in his laboratory include bone development and the generation of progenitor cells (endogenous stem cells) from the present bone tissue to utilize in regeneration via genetic manipulation. Bone development is driven by the growth plate cartilage, which is a made up of cells that create their own strictly controlled environment. As the cells mature, their cell divisions and rearrangements dictate the rate of bone growth and the final size and shape of the bone.

Dr. Andy Dudley
Dong Wang, Ph.D.
Associate Professor, College of Pharmacy - Pharmaceutical Science

Dr. Dong Wang’s laboratory mainly focuses on therapeutic intervention for musculoskeletal diseases. Specifically, his lab have developed a variety of nanomedicine formulations for the improved treatment of inflammatory arthritis, orthopedic implant loosening, impaired fracture healing and periodontal bony defects, etc. These nanomedicine formulations were developed according to a novel passive targeting mechanism termed as ELVIS. In essence, the targeting and accumulation of these colloids at the inflammation associated with these diseases can be attributed to the local vasculature leakage and intensified inflammatory cells mediated phagocytosis. Subsequently, the drug-containing nanomedicine resides within the lysosomal compartment of the hosting cells and gradually release the drug to modulate the inflammation and to stimulate the local tissue repair and regeneration.

Dong Wang, PhD