Hamid Band, M.D., Ph.D.
Elizabeth Bruce Professor, Eppley Institute for Cancer Research
Associate Director of Translational Research, Director Center for Breast Cancer Research
Expertise: Breast Cancer Signaling

Our research in the area of regenerative medicine focuses on novel roles of Cbl-family ubiquitin ligases as regulators of stem cell quiescence. Loss of Cbl/Cbl-b-enforced quiescence in hematopietic stem cells leads to a myeloproliferative disorder whose pathology mimcs that of human leukemia caued by mutatutions in Cbl. As Cbl and Cbl-b proteins are broadly expressed and their combined deletion in mice is embryonic lethal, an important new direction of research in the lab is to decipher the roles of Cbl proteins in the maintenance of epithelial stem cell compartments under homeostasis and during regeneration from injury. Currently, these studies focus on mammmary and intestinal epithelial stem cell homeostasis. Future studies are designed to understand the implications of this new mechanism for brest, colorectal and other cancers as well as in organ regeneration.

 

 Hamid Band, MD, PhD

Vimla Band, Ph.D.
Professor and Vice Chair for Research, Associate Director of the Breast Cancer Center
Ardith & Anna Von Housen Chair, Genetics, Cell Biology and Anatomy, College of Medicine
Expertise: Breast Cancer Stem Cells

Dr. Band’s laboratory studies molecular pathways that make normal breast cells become cancerous in order to identify novel diagnostic/prognostic markers for breast cancers. She has identified a number of novel proteins that are essential for normal growth control of a cell. Her research is beginning to provide novel insights into fundamentally important pathways in cell growth. Her lab has generated different subtypes of progenitor cells that may represent precursors for different subtypes of breast cancers, which are known to have different survival outcomes for patients. Current research is focused on translating these findings into better diagnosis/prognosis of breast cancer.

Vilma Band, PhD

Anne Kessinger, M.D.
Professor, Oncology/Hematology, College of Medicine
Associate Director for Clinical Research, Eppley Cancer Center
Expertise: Cancer, Peripheral Adult Stem Cells

In 1984, Dr. Kessinger postulated that immature bone marrow stem cells circulating in the bloodstream could be harvested from the blood and used for transplants. Through Dr. Kessinger’s ingenuity, UNMC became a leader in the transplants of peripheral adult stem cells, which has become standard practice in treating lymphoma cancer patients. This treatment has become more effective, and much less painful, than the traditional bone-marrow transplants.

Anne Kessinger, M.D.

Angie Rizzino, Ph.D.
Professor, Eppley Institute for Cancer Research
Expertise:Pluripotent Stem Cells, Differentiation and Cancer Stem Cells

The research in Dr. Rizzino's laboratory seeks to decipher the molecular machinery that enables pluripotent stem cells and cancer stem cells to replicate without limit (self-renewal). His research employs a wide range of biochemical, molecular and cellular approaches to more fully understand the transcriptional circuitry of stem cells, as well as the roles of this circuitry in controlling cell proliferation, cellular differentiation and the responses of tumor cells to therapy. His work has shown that transcription factors, which control pluripotency (master regulators), are critical players in a highly interdependent network integrated at multiple levels. His work has also shown that the expression of master regulators of pluripotency must be controlled within very narrow limits by stem cells in order to maintain pluripotency and self-renewal.

Angie Rizzino, Ph.D.

Graham Sharp, Ph.D.
Professor, Genetics Cell Biology and Anatomy; Radiation Oncology; Radiology
Expertise: Cancer Stem Cells

Dr. Sharp is interested in the regulation of stem cells, which can replicate themselves, as well as specialize into many functional cell types. He is working to determine why stem cells decline with age and to improve their use for tissue repair and regeneration.

Graham Sharp, Ph.D.

Rakesh Singh, Ph.D.
Professor, Pathology and Microbiology, College of Medicine
Expertise: Cancer Microenvironment

The overall goal of research in Dr. Singh’s lab is to define the role of host-tumor interaction in the process of tumor progression and metastasis and develop targeted therapeutics.

Rakesh Singh, Ph.D.