985965 Nebraska Medical Center
Omaha, NE 68198-5965
Overzealous immune responses govern the development of autoimmunity and limit the success of transplants. Our laboratory is interested in the role of immune responses during these processes. We are exploring the means whereby self-tolerance is lost leading to the development of autoimmunity. We are also interested in the specific immune responses to regulate the rejection of grafts. An increased understanding of the event that lead to immune stimulation is important for therapy of autoimmune diseases and the success of transplant surgeries.
Boerner BP, Sarvetnick NE. Type 1 diabetes: role of intestinal microbiome in humans and mice. Ann N Y Acad Sci. 2011 Dec;1243:103-18. Review.
Liu SM, Lee DH, Sullivan JM, Chung D, Jäger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov;121(11)4303-10. Epub 2011 Oct 24.
Marleau AM, Sarvetnick NE. IL-18 is required for self-reactive T cell expansion in NOD mice. J Autoimmun. 2011 May;36(3-4):263-77. Epub 2011 Mar 16.
King C, Sarvetnick N. The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions. PLoS One. 2011 Feb 25;6(2):e17049.
Solomon M, Flodström-Tullberg M, Sarvetnick N. Beta-cell specific expression of suppressor of cytokine signaling-1 (SOCS-1) delays islet allograft rejection by down-regulating Interferon Regulatory Factor-1 (IRF-1) signaling. Transpl Immunol. 2011 Apr 15;24(3):181-8. Epub 2010 Dec 1.
Kritzik MR, Lago CU, Kayali AG, Arnaud-Dabernat S, Liu G, Zhang YQ, Hua H, Fox HS, Sarvetnick NE. Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. Endocrine. 2010 Apr;37(2):312-21. Epub 2010 Jan 9.
Solomon M, Balasa B, Sarvetnick N.CCR2 and CCR5 chemokine receptors differentially influence the development of autoimmune diabetes in the NOD mouse. Autoimmunity. 2010 Mar;43(2):156-63.
Additional publication in PubMed
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