Hematopoietic and Mysenchymal

Mark Carlson, M.D.
Associate Professor, Surgery, College of Medicine and the Omaha VA Medical Center
Expertise: Tissue Regeneration, Liquid Bandage, Hematopoietic and Mesenchymal Stem Cells

The long-term goal of Dr. Carlson’s project is to develop a technique of tissue regeneration of the dermis using a combination of stem cells (mesenchymal and/or induced pluripotent) and recombinant proteins (clotting factors, extracellular matrix components, and growth factors) embedded in a nanoengineered polylactide matrix. The short-term goals of this project are to develop and refine two novel hemostatic products for use in severe acute hemorrhage: (1) a liquid-phase formulation of recombinant fibrinogen, thrombin, and Factor XIII; and (2) a hemostatic bandage consisting of a nanoengineered polylactide matrix embedded with the same three recombinant clotting factors.

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Mark Carlson, M.D.

James Hammel, MD
Assistant Professor, Department of Surgery and Chief, Pediatric Cardiac Surgery
Expertise: Heart Valve patches using Mesenchymal Stem Cells


These qualities make MSCs a prime candidate for tissue engineering and regenerative therapies.  Dr. Hammel and his research group are taking a regenerative and bioengineering approach in an attempt to create a novel model for prosthetic heart valves.  By combining various cell types, culture conditions, scaffold material, and protocols, they hope to create a heart valve that will harbor the needs of the heart in a growing child.  To achieve their goal of creating a MSC matrix that can replace a valve while still maintaining all necessary elements, ie. anti-coagulation, viability, pliability, repair, and somatic growth capabilities, they will collaborate with Drs. Linxia Gu and Kevin Cole, engineers in the Mechanical and Material Engineering Department at UNL.  

 

 

Anne Kessinger, M.D.
Professor, Oncology/Hematology, College of Medicine; Associate Director for Clinical Research, Eppley Cancer Center
Expertise: Cancer, Peripheral Adult Stem Cells

In 1984, Dr. Kessinger postulated that immature bone marrow stem cells circulating in the bloodstream could be harvested from the blood and used for transplants. Through Dr. Kessinger’s ingenuity, UNMC became a leader in the transplants of peripheral adult stem cells, which has become standard practice in treating lymphoma cancer patients. This treatment has become more effective, and much less painful, than the traditional bone-marrow transplants.

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Anne Kessinger, M.D.

Ali Nawshad, Ph.D.
Associate Professor, Oral Biology, College of Dentistry
Expertise: Cell Signaling, Epithelial-Mesenchymal Transition

The overall objective of our research is to identify the precise mechanisms of TGFβ signaling that activate diverse pathways to induce number of genes to promote several cellular changes, such as EMT and apoptosis, which are necessary to generate immaculate palate developmental process. However, such cellular changes also are functional in cancer invasion. Our research also explores TGFβ signaling in cancer metastasis by epithelial mesenchymal transition.

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Ali Nawshad, Ph.D.

Nora Sarvetnick, Ph.D.
Professor, Surgery-Transplant, College of Medicine
Expertise: Diabetes, Hematopoietic and Mesenchymal Stem Cells

Dr. Sarvetnick’s team wants to understand factors that contribute to the auto-inflammatory destruction of tissues. This knowledge will help them design new treatments aimed at predicting and curing diabetes. She has been involved in immunology research for 20 years and has made many seminal discoveries regarding the immunological basis of disease. Her group has developed numerous animal models that have been used to advance the field. They are now transitioning toward clinical immunology.

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Graham Sharp, Ph.D.
Professor, Genetics Cell Biology and Anatomy; Radiation Oncology; Radiology
Expertise: Cancer, Peripheral Adult Stem Cells, Stem Cells

Dr. Sharp is interested in the regulation of stem cells, which can replicate themselves, as well as specialize into many functional cell types. He is working to determine why stem cells decline with age and to improve their use for tissue repair and regeneration.

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Graham Sharp, Ph.D.

 

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