David W. Mercer, MD, FACS

David W. Mercer, MD

Professor, Division of General Surgery
McLaughlin Professor and Chairman, Department of Surgery
University of Nebraska Medical Center
983280 Nebraska Medical Center
Omaha, NE 68198-3280, USA
Phone: 402-559-8272
Fax: 402-559-6749

Curriculum Vitae

Graduate: University of Wisconsin-Madison Medical School, Madison, WI
Residency: Temple University Hospital, Philadelphia, PA
Fellowship: Research Fellowship, Temple University Hospital, Philadelphia, PA
Board Certification:

American Board of Surgery General Surgery
Academic Appointment: Professor of Surgery
Other Appointments: Chairman, Department of Surgery
Sub-Specialty General Surgery & Trauma
Research Interests: Role of Gut in Pathogenesis of MOF

Publications:

  • McGuire MF, Sriram Iyengar M, Mercer DW. Data driven linear algebraic methods for analysis of molecular pathways: application to disease progression in shock/trauma. J Biomed Inform. 4/2012: 372-87 Abstract
  • Carson JS, Smith L, Are M, Edney J, Azarow K, Mercer DW, Thompson JS, Are C. National trends in minimally invasive and open operative experience of graduating general surgery residents: implications for surgical skills cirricula development. Am J Surg. 12/2011: 720-6 Abstract
  • Jawa RS, Young DH, Wagner M, Yetter D, Schostrom V, Cemaj S, Nelson L, Ramey R, Sorenson M, Schedhelm M, Mercer DW, Stothert J. Two hospitals with 1 trauma system: a joint approach to the care of the injured patient. Am J Surg. 4/2012 Abstract
  • Ward JL, Harting MT, Cox CS Jr., Mercer DW. Effects of ketamine on endotoxin and traumatic brain injury induced production in the rat.  J Trauma. 6/2011: 1471-9 Abstract
  • McGuire MF, Inyengar MS, Mercer DW. Computational approaches for translational clinical research in disease progression.  J Invest Med. 8/2011: 893-903 Abstract
  • McGuire MF, Iyengar MS, Mercer DW. Computational approaches for translational clinical brain injury induced cytokine production. J Trauma.
  • McGonzalez EA, McGuire M, Suliburk JW, Adams SD, Kozar RA, Iyengar S, McKinley BA, Moore FA, Mercer DW: Early cytokine production risk stratifies trauma patients for multiple organ failure. Archives of Surgery (in press). Abstract
  • Cocanour CS, Dial ED, Lichtenberger LM, Gonzalez EA, Kozar RA, Moore FA, Mercer DW: Gastric alkalinization following major trauma. Journal of Trauma 64: 681-687, 2008. Abstract
  • Suliburk JW, Kao LS, Kozar RA, Mercer DW: Training future surgical scientists:realities and recommendations. Annals of Surgery 247: 741-749, 2008. Abstract
  • West SD, Suliburk JW, Helmer KS, Mercer DW: Cyclo-oxygenase 1 suppresses lipopolysaccharide induced changes in rat gastric inducible nitric oxide synthase. Critical Care Medicine 36: 572-579, 2008. Abstract
  • Dial E, Lopez-Storey M, Adams SD, Lichtenberger L, Gonzalez EA, McKinley B, Moore FA, Mercer DW: A report on associations between gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma. Journal of Trauma 64: 105-110, 2008. Abstract
  • Suliburk JW, Helmer KS, Mercer DW: The gut in SIRS and sepsis: enzyme systems battling between recovery and multiple organ failure. European Surgical Research 40: 184-189, 2008.
  • Adams SD, Radhakrishnan RS, Helmer KS, Mercer DW: Effects of anesthesia on lipopolysaccharide induced changes in serum cytokines. Journal of Trauma 65: 170-174, 2008. Abstract
  • Adams SD, Mercer DW: Fulminant Clostridium difficile colitis. Current Opinion in Critical Care 13: 450-455, 2007. Abstract
  • Suliburk JW and Mercer DW: Ketamine attenuates early lipopolysaccharide induced gastric dysfunction:role of stress inducible phosphoproteins. Journal of Trauma 62: 316-319, 2007. Abstract
  • Gonzalez EA, Kozar RA, Suliburk JW, Weisbrodt NW, Mercer DW, Moore FA: Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia and reperfusion. Journal of Trauma 61: 63-74, 2006. Abstract
  • Lau WK, Mercer DW, Itani KM, Nicolau DP, Kuti JL, Mansfield D, Dana A: A randomized, open-label, comparative study of piperacillin/tazobactam administered by continuous infusion vs intermittent infusion for the treatment of hospitalized patients with complicated intra-abdominal infections. Antimicrobials Agents and Chemotherapy 50: 3556-3561, 2006.
  • Robinson EK, West SD, Mercer DW: Salicylate enhances rat gastric gelatinase activity. Journal of Surgical Research 133: 69-75, 2006. Abstract
  • Robinson EK, Seaworth CM, Suliburk JW, Adams SA, Kao LS, Mercer DW: Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia. Shock 25: 507-514, 2006. Abstract
  • Helmer K, Suliburk JW, Mercer DW: Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1. Digestive Diseases and Sciences 51: 1571-1581, 2006. Abstract
  • Robinson EK, West SD, Garay A, Mercer DW: Rat Gastric Gelatinase Induction During Endotoxemia. Digestive Diseases and Sciences 51: 548-559, 2006. Abstract
  • Gonzalez EA, Kozar RA, Suliburk JW, Weisbrodt NW, Mercer DW, Moore FA: Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis. Journal of Trauma 5: 1092-1098, 2005. Abstract
  • Kao LS, Knight MT, Lally KP, Mercer DW: The impact of diabetes in patients with necrotizing soft tissue infections: Surgical Infections 6: 427-438, 2005. Abstract
  • Robinson EK, Kennison SD, Suliburk JW, Mercer DW: Rat gastric injury following lipopolysaccharide: Role of inducible nitric oxide synthase. Surgery 138: 523-529, 2005. Abstract
  • Suliburk JW, Robinson EK, Kennison S, Mercer DW: Time dependent aggravation or attenuation of LPS induced gastric injury by nitric oxide synthase inhibition. Journal of Surgical Research 129: 265-271, 2005. Abstract
  • West SD, Suliburk JW, Smith GS, Mercer DW: Effects of LPS on gastric stasis: Role of cyclooxygenase. Digestive Diseases and Sciences 51: 754-765, 2006. Abstract
  • Suliburk JW, Gonzalez E, Kennison S, Helmer KS, Mercer DW: Differential effects of anesthesics on endotoxin induced liver injury. Journal of Trauma 58: 711-717, 2005. Abstract
  • Suliburk JW, Gonzalez E, Robinson EK, Helmer KS, Mercer DW: Ketamine attenuates liver injury due to endotoxemia: Role of COX-2. Surgery 138; 134-140, 2005. Abstract
  • Suliburk JW, Gonzalez E, Moore-Olufemi, Weisbrodt N, Moore FA, Mercer DW: Ketamine attenuates lipopolysaccharide induced gastric luminal fluid accumulation. Journal of Surgical Research 127: 203-207, 2005. Abstract
  • Mercer DW, Academic Surgery: Can We Adapt? Surgery 138: 115-124,2005. Abstract
  • West SD, Mercer DW: Bombesin induced gastroprotection. Annals of Surgery 241: 227-231, 2005. Abstract
  • Helmer KS, West SD, Vilela R, Chang L, Cui Y, Kone BC, Mercer DW. Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression. Annals of Surgery. 239:501-509, 2004. Abstract
  • West SD, Mercer DW: Cholecystokinin induced gastroprotection: A review of current protective mechanisms. Digestive Diseases and Sciences 49:361-366, 2004. Abstract
  • West SD, Robinson EK, Delu AN, Ligon RE, Kao LS, Mercer DW: Diverticulitis in the younger patient. American Journal of Surgery 186: 743-746, 2003. Abstract
  • Helmer KS, Cui Y, Dewan A, Mercer DW: Ketamine/xylazine attenuates LPS-induced iNOS expression in various rat tissues. Journal of Surgical Research. 112:70-78, 2003. Abstract
  • West SD, Helmer KS, Chang LK, Cui Y, Greeley GH, Mercer DW: Cholecystokinin induced gastric protection: Role of nitric oxide and blood flow. American Journal of Physiology 284:G399-G410, 2003. Abstract
  • Helmer KS, Cui Y, Chang L, Dewan A, Mercer DW: Effects of ketamine/xylazine on expression of TNF-α, iNOS, and COX-2. Shock 20:63-69, 2003. Abstract
  • Mercer, DW, Liu TH: Open Truncal Vagotomy. Operative Techniques in General Surgery 5:80-85, 2003.
  • Liu TH, Consorti ET, Mercer DW: Laparoscopic cholecystectomy for acute cholecystitis: Technical considerations and outcome. Seminars in Laparoscopic Surgery 9(1):24-31, 2002. Abstract
  • Helmer K, West SD, Shipley GL, Chang L, Cui Y, Mailman D, Mercer DW: Gastric nitric oxide synthase expression during endotoxemia: Implications in mucosal defense. Gastroenterology 123: 173-186, 2002. Abstract
  • Helmer KS, Robinson EK, Lally KP, Vasquez JC, Kwong KL, Liu TH, Mercer DW: Standardized patient care guidelines reduce infectious morbidity in appendectomy patients. American Journal of Surgery 183: 608-613, 2002. Abstract
  • Helmer KS, Chang L, CiuY, Mercer DW: Induction of NF-κB, Iκ-B-alpha, and iNOS in rat gastric mucosa during endotoxemia Journal of Surgical Research 104: 46-52, 2002. Abstract
  • Liu TH, Robinson EK, Helmer KS, West SD, Casteneda AA, Chang L, Mercer DW: Does upregulation of inducible nitric oxide synthase play a role in hepatic injury? Shock 18: 549-554, 2002. Abstract
  • Kwong KL, Liu TH, Tamm EP, Gill BS, Brown S, Mercer DW: Are clinical and radiologic scores useful early predictors in identifying acute pancreatitis patients with complicated ICU course? Journal of Critical Care Medicine 31: 1026-30, 2003.
  • Dial EJ, Romero JJ, Villa X, Mercer DW, Lichtenberger LM: Lipopolysaccharide induced gastrointestinal injury in rats: Role of surface hydrophobicity and bile salts. Shock 17:77-86, 2002. Abstract
  • Liu TH, Mehall JR, Mercer DW: Image of the Month: Acute gastric dilation with necrosis. Arch Surg 136: 1437-1438, 2001. Abstract
  • Hassoun HT, Weisbrodt NW, Mercer DW, Kozar RA, Moody FG, Moore FA: Inducible nitric oxide synthase (NOS) mediates impaired small intestinal transit after severe gut ischemia/reperfusion (I/R). Journal of Surgical Research 97:150-154, 2001. Abstract
  • Dempsey DT, Ashley SW, Mercer DW, Sillin LF: Peptic ulcer surgery in the H. pylori era. Part 2: Indications for operation. Contemporary Surgery 57(9):433-441, 2001.
  • Dempsey DT, Ashley SW, Mercer DW, Sillin LF: Peptic ulcer surgery in the H. pylori era. Part 1: Medical and surgical overview. Contemporary Surgery 57(8):385-389, 2001.
  • Kim YS, Mercer DW: Effects of vagotomy and atropine on lipopolysaccharide induced gastroprotection. Digestive Diseases and Sciences 46:1526-1532, 2001.
  • Liu TH, Consorti ET, Kawashima A, Tamm EP, Kwong KL, Sellin JH, Peden EK, Mercer DW: Patient evaluation and management with selective utilization of magnetic resonance cholangiography and endoscopic retrograde chalangiopancreatography prior to laparoscopic cholecystectomy. Annals of Surgery 234:33-40, 2001. Abstract
  • Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA: Post injury multiple organ failure: role of the gut. Shock 15(1):1-7, 2001. Abstract
  • Castaneda AA, Kim YS, Chang L, Cui Y, Mercer DW: Nitric oxide synthase inhibition negates bombesin-induced gastroprotection. Surgery 128:422-428, 2000. Abstract
  • Castaneda AA, Vilela R, Chang L, Mercer DW: Effects of intestinal ischemia/reperfusion injury on gastric acid secretion. Journal of Surgical Research 90:88-93, 2000. Abstract
  • Kim YS, Mercer DW: Effects of vagotomy and atropine on lipopolysaccharide induced gastroprotection. Surgical Forum 51:27-28, 2000.