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Aleata A. Triplett, M.Sc.

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Research Technologist

University of Nebraska Medical Center
985950 Nebraska Medical Center, DRCII
Omaha, NE 68198-5950
Tel: (402) 559-3289
Fax: (402) 559-8270
E-mail: atriplett@unmc.edu

Education:

1997 - B.Sc., Biological Sciences, University of Nebraska Lincoln, Lincoln, NE
2001 - M.Sc., Biological Sciences, University of Nebraska Lincoln, Lincoln, NE

2001 - present
Research Technologist II

Aleata joined our group in October of 2001. She is involved in numerous projects, and she was pivotal in generating and analyzing the WAP knockout mice. In March of 2008, Aleata received the Chancellor’s Council Silver ‘U’ Award. This award is given to UNMC employees, who provide consistent performance that exceeds expectations. On May 12, 2011, Aleata was featured at the UNMC News (Lookin' at U - Aleata Triplett).

 

Publications:

Krempler, A.; M. D. Henry; A. A. Triplett and K.-U. Wagner (2002): Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53 independent cell death.
J. Biol. Chem. 277 (45): 43216-43223

Wagner, K.-U., A. Krempler, Y. Qi, K. Park, M. D. Henry, A. A. Triplett, G. Riedlinger, E. B. Rucker III, and L. Hennighausen (2003): Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.
Mol. Cell. Biol. 23: 150-162

Wagner, K.-U.; A. Krempler; A.A. Triplett, Y. Qi; N.M. George; J. Zhu and H. Rui (2004): Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice.
Mol. Cell. Biol. 24: 5510-5520

Carstens; M.J.; A. Krempler; A.A. Triplett; M. van Lohuizen and K.-U. Wagner (2004): Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells.
J. Biol. Chem. 279 (34):35984-35994

Henry, M.D.; A.A. Triplett; K.B. Oh; G.H. Smith and K.-U. Wagner (2004): Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice.
Oncogene 23 (41): 6980–6985

Krempler, A.; Y. Qi; A.A. Triplett; J. Zhu; H. Rui and K.-U. Wagner (2004): Generation of a conditional knockout allele for the Janus Kinase 2 (Jak2) gene in mice.
Genesis 40 (1):52-57

Triplett, A.A.; K. Sakamoto; L.A. Matulka; L. Shen; G.H. Smith and K.-U. Wagner (2005): Expression of the Whey Acidic Protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
Genesis 43 (1): 1-11

Matulka, L.A.; A.A. Triplett and K.-U. Wagner (2007): Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells.
Developmental Biology 303 (1): 29–44

Sakamoto, K; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2007): The Janus kinase 2 (Jak2) is required for expression and nuclear accumulation of Cyclin D1 in proliferating mammary epithelial cells.
Molecular Endocrinology 21 (8): 1877-1892

Triplett, A.A.; Montagna, C. and K.-U. Wagner (2008): A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.
Neoplasia 10 (12): 1325–1334

Creamer, B.A.; A.A. Triplett and K.-U. Wagner (2008): Longitudinal analysis of mammogenesis using a novel tet-inducible mouse model and in vivo imaging.
Genesis 47 (4):234-245

Sakamoto, K.; W.C. Lin; A.A. Triplett and K.-U. Wagner (2009): Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. Cancer Research 69 (16): 6642-6650

Zhang, Q.; A.A. Triplett; D.W. Harms. W.C. Lin; B.A. Creamer; A. Rizzino and K.-U. Wagner (2010): Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. Transgenic Research 19 (3): 499-509 (Epub Oct 8. 2009) contributed equally

Creamer, B.A.; K. Sakamoto; J.W. Schmidt; A.A. Triplett, R. Moriggl and K.-U. Wagner (2010): Stat5 promotes survival of mammary epithelial cell through transcriptional activation of a distinct promoter in Akt1. Mol. Cell. Biol. 30 (12): 2957–2970

Sakamoto, K; A.A. Triplett; L.A. Schuler and K.-U. Wagner (2010): Jak2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 29 (39): 5359-5369

Zhang, Q.; K. Sakamoto; C. Liu; A.A. Triplett; W.C. Lin; H. Rui and K.-U. Wagner (2011): Cyclin D3 compensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Research 71 (24): 7513-7524

Lin, W.C.; N. Rajbhandari; C. Liu; K. Sakamoto; Q. Zhang; A.A. Triplett; S.K. Batra; R. Opavsky; D.W. Felsher;  D.J. DiMaio; M.A. Hollingsworth; J.P. Morris 4th; M. Hebrok; A.K. Witkiewicz; J.R. Brody; H.Rui and K.-U. Wagner (2013): Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer. Cancer Research 73 (6): 1821-1830

Lin, W.C. ‡; J.W. Schmidt ‡; B.A. Creamer; A.A. Triplett and K.-U. Wagner * (2013): Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung. PLoS ONE 8 (4): e60902  ‡ contributed equally

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. Anderson; P.N. Tsichlis; G. Leone and K.-U. Wagner (2014):  Stat5 regulates the PI3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol. Cell. Biol. 34 (7):1363-1377

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. W.W. West and K.-U. Wagner (2014): Novel transcripts from a distinct promoter that encode the full-length Akt1 in human breast cancer cells. BMC Cancer 14 (1):195

PubMed