Karoline C Manthey, Ph.D.
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Postdoctoral Research Associate
2002 – Diploma, Nutritional Sciences, Justus-Liebig University Giessen ( Germany)
2005 – M.Sc., Nutritional Sciences, University of Nebraska, Lincoln
2010 – Ph.D., Medical Sciences Interdepartmental Area, University of Nebraska Medical Center, College of Dentistry; thesis: “Phosphorylation of Replication Protein A and its significance in the cellular response to DNA damage”
June of 2010 - June of 2013
Postdoctoral Research Associate, Eppley
Institute for Research in Cancer and Allied Diseases, University
of Nebraska Medical Center
In July of 2013, Karoline assumed a faculty position at Coastal Carolina University.
Morris, C.R.; M.J. Stanton; K.C. Manthey; K.B. Oh and K.-U. Wagner (2012): A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death. PLoS ONE 7 (3): e34308
Liyanage, P.M., Manthey, K.C., Dassanayake, R.P., Kuszynski, C.A., Oakley, G.G., Duhamel, G.E., (2010). Helicobacter hepaticus Cytolethal Distending Toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway. Helicobater 15 (2): 98-107.
Manthey, K.C., Glanzer J.G., Dimitrova D.D., Oakley G.G. (2010). Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines. Head Neck 32 (5): 636-45.
Manthey, K. C., Opiyo, S., Glanzer, J. G., Dimitrova, D., Elliott, J., & Oakley, G. G. (2007). NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci 120 (Pt 23), 4221-4229.
Manthey, K. C., Rodriguez-Melendez, R., Hoi, J. T., & Zempleni, J. (2006). Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J Nutr Biochem 17 (4): 250-256.
Werner, R., Manthey, K. C., Griffin, J. B., & Zempleni, J. (2005). HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem 16 (10): 617-624.
Manthey, K. C., Chew, Y. C., & Zempleni, J. (2005). Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems. J Nutr 135 (5): 978-982.
Manthey, K. C., Griffin, J. B., & Zempleni, J. (2002). Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells.J Nutr 132 (5): 887-892.