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Karoline C Manthey, Ph.D.

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Postdoctoral Research Associate



2002 – Diploma, Nutritional Sciences, Justus-Liebig University Giessen ( Germany)

2005 – M.Sc., Nutritional Sciences, University of Nebraska, Lincoln

2010 – Ph.D., Medical Sciences Interdepartmental Area, University of Nebraska Medical Center, College of Dentistry; thesis: “Phosphorylation of Replication Protein A and its significance in the cellular response to DNA damage”


June of 2010 - June of 2013
Postdoctoral Research Associate, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center

In July of 2013, Karoline assumed a faculty position at Coastal Carolina University.



Morris, C.R.; M.J. Stanton; K.C. Manthey; K.B. Oh and K.-U. Wagner (2012): A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death. PLoS ONE 7 (3): e34308


Previous Publications:

Liyanage, P.M., Manthey, K.C., Dassanayake, R.P., Kuszynski, C.A., Oakley, G.G., Duhamel, G.E., (2010). Helicobacter hepaticus Cytolethal Distending Toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway. Helicobater 15 (2): 98-107.

Manthey, K.C., Glanzer J.G., Dimitrova D.D., Oakley G.G. (2010). Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines. Head Neck 32 (5): 636-45.

Manthey, K. C., Opiyo, S., Glanzer, J. G., Dimitrova, D., Elliott, J., & Oakley, G. G. (2007). NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci 120 (Pt 23), 4221-4229.

Manthey, K. C., Rodriguez-Melendez, R., Hoi, J. T., & Zempleni, J. (2006). Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. J Nutr Biochem 17 (4): 250-256.

Werner, R., Manthey, K. C., Griffin, J. B., & Zempleni, J. (2005). HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem 16 (10): 617-624.

Manthey, K. C., Chew, Y. C., & Zempleni, J. (2005). Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems. J Nutr 135 (5): 978-982.

Manthey, K. C., Griffin, J. B., & Zempleni, J. (2002). Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells. J Nutr 132 (5): 887-892.