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Kazuhito Sakamoto, Ph.D.

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Research Assistant Professor

University of Nebraska Medical Center
985950 Nebraska Medical Center, DRCII
Omaha, NE 68198-5950
Tel: (402) 559-3536
Fax: (402) 559-8270
E-mail: ksakamoto@unmc.edu

 

Education:

1999 - B.Sc., Animal Science, Nippon Veterinary and Animal Science University (Japan)

2001 - M.Sc., Animal Science, Tohoku University (Japan)

2004 - Ph.D., Animal Science, Tohoku University (Japan); thesis: "Regulation of functional differentiation of bovine mammary epithelial cells in vitro"

2004 - 2011
Visiting Research Associate, Senior Research Associate (since 2008), Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center

Kazuhito received a postdoctoral fellowship from the Susan G. Komen Foundation (2008-2009).

 

Publications:

Triplett, A.A.; K. Sakamoto; L.A. Matulka; L. Shen; G.H. Smith and K.-U. Wagner (2005): Expression of the Whey Acidic Protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
Genesis 43 (1): 1-11

Sakamoto, K; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2007): The Janus kinase 2 (Jak2) is required for expression and nuclear accumulation of Cyclin D1 in proliferating mammary epithelial cells.
Molecular Endocrinology 21 (8): 1877-1892

Neilson, L.M.; J. Zhu; J. Xie; M.G. Malabarba; K. Sakamoto ; K.-U. Wagner; R.A. Kirken and H. Rui (2007): Coactivation of Jak1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Stat3 and Enhancement of Akt and Stat5a/b Pathways.
Molecular Endocrinology 21 (9): 2218–2232

Sakamoto, K.; W.C. Lin; A.A. Triplett and K.-U. Wagner (2009): Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. Cancer Research 69 (16): 6642-6650

Creamer, B.A.; K. Sakamoto; J.W. Schmidt; A.A. Triplett, R. Moriggl and K.-U. Wagner (2010): Stat5 promotes survival of mammary epithelial cell through transcriptional activation of a distinct promoter in Akt1. Mol. Cell. Biol. 30 (12): 2957–2970

Sakamoto, K; A.A. Triplett; L.A. Schuler and K.-U. Wagner (2010): Jak2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 29 (39): 5359-5369

Rochman Y; M. Kashyap; G.W. Robinson; K. Sakamoto; J. Gomez-Rodriguez; K.-U. Wagner and W.J. Leonard (2010): Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc. Natl. Acad. Sci. U.S.A 107 (45): 19455-19460

Rucker, E.B.; A.N. Hale; D.C. Durtschi; K. Sakamoto and K.-U. Wagner (2011): Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax. Genesis 49 (1): 24-35

Zhang, Q.; K. Sakamoto; C. Liu; A.A. Triplett; W.C. Lin; H. Rui and K.-U. Wagner (2011): Cyclin D3 compensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Research 71 (24): 7513-7524

Sakamoto, K.; J.W. Schmidt and K.-U. Wagner (2012): Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. PLoS ONE 7(8): e43778

Lin, W.C.; N. Rajbhandari; C. Liu; K. Sakamoto; Q. Zhang; A.A. Triplett; S.K. Batra; R. Opavsky; D.W. Felsher;  D.J. DiMaio; M.A. Hollingsworth; J.P. Morris 4th; M. Hebrok; A.K. Witkiewicz; J.R. Brody; H.Rui and K.-U. Wagner (2013): Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer. Cancer Research 73 (6): 1821-1830

Bell, B.D.; M. Kitajima; R.P. Larson; T.A. Stoklasek; K. Dang; K. Sakamoto; K.-U. Wagner; B. Reizis; L. Hennighausen and S.F. Ziegler (2013): STAT5 is critical in Dendritic Cells for development of TH2- but not TH1-dependent Immunity.Nature Immunology 14 (4): 364-371

Zhang, Q.; K. Sakamoto and K.-U. Wagner (2014): D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells. Mol. Cell. Endocrinol. 382: 583–592 (Epub April 4, 2013)

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. Anderson; P.N. Tsichlis; G. Leone and K.-U. Wagner (2014):  Stat5 regulates the PI3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol. Cell. Biol. 34 (7):1363-1377

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. W.W. West and K.-U. Wagner (2014): Novel transcripts from a distinct promoter that encode the full-length Akt1 in human breast cancer cells. BMC Cancer 14 (1):195

Akada, H.; S. Akada; R.E. Hutchison; K. Sakamoto; K.-U. Wagner and G. Mohi (2014): Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. Stem Cells, in press

PubMed