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Wan-chi Lin, Ph.D.

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Graduate Student/Postdoctoral Research Associate

 

Education:

2002 B.Sc., Department of Biology, National Cheng Kung University, Taiwan

2002 M.Sc. Department of Biochemistry, National Cheng Kung University, Taiwan
Master Thesis: “ The mechanism of the exogenous mutant p53 enhanced cisplatin-induced apoptosis in the bladder cancer cell line TCCSUP”

2005 - 2012, Graduate Student, Cancer Research Graduate Program (CRGP), Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center


Awards/Achievements:
1999- National Science Council undergraduate student's research grant—“The effect of cAMP and cGMP on the rat hippocampus in memory formation of one-way inhibitory avoidance learning”

 

Wan-chi joined our group in January of 2006. From July of 2008 until 2010, Wan-chi was supported through the UNMC Graduate Studies Office on a Research Assistantship. In 2011, she won First Place for her oral presentation at the 42nd Midwest Student Biomedical Research Forum. Wan-chi defended her dissertation on November 29, 2011 [Title: The Role of c-Myc in Pancreatic Cancer Initiation and Progression]. After being promoted to Postdoctoral Research Associate (2012) and wrapping up her oustanding work in the lab (2 papers), she joined in 2013 a research team led by Dr. Mien-Chie Hung, who is the founding director of the Center for Molecular Medicine at the China Medical University Hospital in Taichung, Taiwan.

 

Publications:

Sakamoto, K.; W.C. Lin; A.A. Triplett and K.-U. Wagner (2009): Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. Cancer Research 69 (16): 6642-6650

Zhang, Q.; A.A. Triplett; D.W. Harms. W.C. Lin; B.A. Creamer; A. Rizzino and K.-U. Wagner (2010): Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. Transgenic Research 19 (3): 499-509 (Epub Oct 8. 2009) contributed equally

Zhang, Q.; K. Sakamoto; C. Liu; A.A. Triplett; W.C. Lin; H. Rui and K.-U. Wagner (2011): Cyclin D3 ompensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Research 71 (24): 7513-7524

Lin, W.C.; N. Rajbhandari; C. Liu; K. Sakamoto; Q. Zhang; A.A. Triplett; S.K. Batra; R. Opavsky; D.W. Felsher;  D.J. DiMaio; M.A. Hollingsworth; J.P. Morris 4th; M. Hebrok; A.K. Witkiewicz; J.R. Brody; H.Rui and K.-U. Wagner (2013): Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer. Cancer Research 73 (6): 1821-1830

Lin, W.C. ‡; J.W. Schmidt ‡; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2013): Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung. PLoS ONE 8 (4): e60902  ‡ contributed equally

Lin W.C..; N. Rajbhandari and K.-U. Wagner (2014): Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. Cancer Research, in press


previous publications:

Lin WC, Chuang YC, Chang YS, Lai MD, Teng YN, Su IJ, Wang CC, Lee KH, Hung JH.(2012): Endoplasmic Reticulum Stress Stimulates p53 Expression through NF-κB Activation. PLoS ONE (7): e39120

MD Lai , WC Lin , YM Sun , FL Chang . Apr, 2005. Phosphorylated and hypoacetylated mutant p53 enhances cisplatin-induced apoptosis through caspase-9 pathway in the absence of transcriptional activation or translation. Int. J. Mol. Med. 15(4):725-34

JH Hung, IJ Su, HY Lei, HC Wang, WC Lin, WT Chang, W Huang, WC Chang, YS Chang, CC Chen, MD Lai. Nov, 2004. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J. Biol Chem. 279(45): 46384-92.

WC Lin, YC Chuang, IJ Su, HY Lei, WT Chang, WY Huang, WC Chang, and MD Lai. Nov, 2003. ER stress induced p53 expression through NF-kappa B activation in breast cancer cell line MCF-7. 3 rd Symposium for the Society of Biochemistry and Molecular Biology, Tainan, Taiwan.

WC Lin , FL Chang, MD Lai.Sept, 2002. The mechanism of the exogenous mutant p53 enhanced cisplatin-induced apoptosis in the bladder cancer cell line TCCSUP. 16 th FAOBMB (Federation of Asian and Oceanian Biochemists and Molecular Biologists Inc.) Symposium, Taipei, Taiwan.

PubMed