Wan-chi Lin, Ph.D.
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Graduate Student/Postdoctoral Research Associate
Department of Biology, National Cheng Kung University, Taiwan
Department of Biochemistry, National Cheng Kung University, Taiwan
Master Thesis: “ The mechanism of the exogenous mutant p53 enhanced cisplatin-induced apoptosis in the bladder cancer cell line TCCSUP”
2005 - 2012, Graduate Student, Cancer Research Graduate Program (CRGP), Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center
National Science Council undergraduate student's research grant—“The effect of cAMP and cGMP on the rat hippocampus in memory formation of one-way inhibitory avoidance learning”
Wan-chi joined our group in January of 2006. From July of 2008 until 2010, Wan-chi was supported through the UNMC Graduate Studies Office on a Research Assistantship. In 2011, she won First Place for her oral presentation at the 42nd Midwest Student Biomedical Research Forum. Wan-chi defended her dissertation on November 29, 2011 [Title: The Role of c-Myc in
Pancreatic Cancer Initiation
and Progression]. After being promoted to Postdoctoral Research Associate (2012) and wrapping up her oustanding work in the lab (2 papers), she joined in 2013 a research team led by Dr. Mien-Chie Hung, who is the founding director of the Center for Molecular Medicine at the China Medical University Hospital in Taichung, Taiwan.
Sakamoto, K.; W.C. Lin; A.A. Triplett and K.-U. Wagner (2009): Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. Cancer Research 69 (16): 6642-6650
Zhang, Q.‡; A.A. Triplett‡; D.W. Harms. W.C. Lin; B.A. Creamer; A. Rizzino and K.-U. Wagner (2010): Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. Transgenic Research 19 (3): 499-509 (Epub Oct 8. 2009) ‡contributed equally
Zhang, Q.; K. Sakamoto; C. Liu; A.A. Triplett; W.C. Lin; H. Rui and K.-U. Wagner (2011): Cyclin D3 ompensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Research 71 (24): 7513-7524
Lin, W.C.; N. Rajbhandari; C. Liu; K. Sakamoto; Q. Zhang; A.A. Triplett; S.K. Batra; R. Opavsky; D.W. Felsher; D.J. DiMaio; M.A. Hollingsworth; J.P. Morris 4th; M. Hebrok; A.K. Witkiewicz; J.R. Brody; H.Rui and K.-U. Wagner (2013): Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer. Cancer Research 73 (6): 1821-1830
Lin, W.C. ‡; J.W. Schmidt ‡; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2013):
Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung. PLoS ONE 8 (4): e60902 ‡ contributed equally
Lin W.C..; N. Rajbhandari and K.-U. Wagner (2014): Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. Cancer Research, in press
Lin WC, Chuang YC, Chang YS, Lai MD, Teng YN, Su IJ, Wang CC, Lee KH, Hung JH.(2012): Endoplasmic Reticulum Stress Stimulates p53 Expression through NF-κB Activation. PLoS ONE (7): e39120
MD Lai , WC Lin , YM Sun , FL Chang . Apr, 2005. Phosphorylated and hypoacetylated mutant p53 enhances cisplatin-induced apoptosis through caspase-9 pathway in the absence of transcriptional activation or translation. Int. J. Mol. Med. 15(4):725-34
JH Hung, IJ Su, HY Lei, HC Wang, WC Lin, WT Chang, W Huang, WC Chang, YS Chang, CC Chen, MD Lai. Nov, 2004. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J. Biol Chem. 279(45): 46384-92.
WC Lin, YC Chuang, IJ Su, HY Lei, WT Chang, WY Huang, WC Chang, and MD Lai. Nov, 2003. ER stress induced p53 expression through NF-kappa B activation in breast cancer cell line MCF-7. 3 rd Symposium for the Society of Biochemistry and Molecular Biology, Tainan, Taiwan.
WC Lin , FL Chang, MD Lai.Sept, 2002. The mechanism of the exogenous mutant p53 enhanced cisplatin-induced apoptosis in the bladder cancer cell line TCCSUP. 16 th FAOBMB (Federation of Asian and Oceanian Biochemists and Molecular Biologists Inc.) Symposium, Taipei, Taiwan.