Job Openings


Starting 2011: [2011] [2012] [2013]

Starting 2001: [2001] [2002] [2003] [2004] [2005/06] [2007] [2008] [2009/10]

Starting 1996: [1996-98] [1999/2000]



Akada, H.; S. Akada; R.E. Hutchison; K. Sakamoto; K.-U. Wagner and G. Mohi (2014): Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. Stem Cells, in press  [Abstract] [PDF]

Lin W.C..; N. Rajbhandari and K.-U. Wagner (2014): Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. Cancer Research, in press [Abstract] [PDF]

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. W.W. West and K.-U. Wagner (2014): Novel transcripts from a distinct promoter that encode the full-length Akt1 in human breast cancer cells. BMC Cancer 14 (1):195 [Abstract] [PDF] [Open Access]

Grisouard J.; H. Hao-Shen; S. Dirnhofer; K.-U. Wagner and R.C. Skoda (2014): Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia. Haematologica 99 (4): e52-54  [Abstract] [PDF] [Open Access]

Schmidt, J.W.; B.L. Wehde;  K. Sakamoto; A.A. Triplett; S.M. Anderson; P.N. Tsichlis; G. Leone and K.-U. Wagner (2014):  Stat5 regulates the PI3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol. Cell. Biol. 34 (7):1363-1377 [Abstract] [PDF]

Zhang, Q.; K. Sakamoto and K.-U. Wagner (2014): D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells. Mol. Cell. Endocrinol. 382: 583–592 (Epub April 4, 2013)  [Abstract] [PDF]

Back to top


Nordstrom, S.M.; J.L. Tran; B.C. Sos; K.-U. Wagner and E.J. Weiss (2013): Disruption of JAK2 in adipocytes impairs Lipolysis and Improves Fatty Liver in Mice With Elevated GH. Molecular Endocrinology 27 (8): 1333-1342 [Abstract] [PDF]

Yang, P.; Y. Zhang;  J. Pang; S. Zhang;  Q. Yu; L. He; K.-U. Wagner; Z. Zhou and C.-Y. Wang (2013): Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities. Am. J. Pathol. 183 (2): 617-625 [Abstract] [PDF]

Xin, H.; R. Lu; H. Lee; W. Zhang; C. Zhang; J. Deng; Y. Liu; S. Shen;  K.-U. Wagner; S. Forman; R. Jove and H. Yu (2013: G-protein coupled receptor agonist BV8/prokineticin-2 and STAT3 form a feed-forward loop in both normal and malignant myeloid cells. J. Biol. Chem. 288 (19): 13842-13849 [Abstract] [PDF]

Lin, W.C. ‡; J.W. Schmidt ‡; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2013): Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung. PLoS ONE 8 (4): e60902    ‡ contributed equally [Abstract] [PDF] [Open Access]

Park, S.O.; H.L. Wamsley; K. Bae; Z. Hu; X. Li; S.W. Choe; W.B. Slayton; S.P. Oh; K.-U. Wagner and  P.P Sayeski (2013): Conditional Deletion of Jak2 Reveals an Essential Role in Hematopoiesis throughout Mouse Ontogeny: Implications for Jak2 Inhibition in Humans. PLoS ONE 8 (3): e59675 [Abstract] [PDF] [Open Access]

Lin, W.C.; N. Rajbhandari; C. Liu; K. Sakamoto; Q. Zhang; A.A. Triplett; S.K. Batra; R. Opavsky; D.W. Felsher;  D.J. DiMaio; M.A. Hollingsworth; J.P. Morris 4th; M. Hebrok; A.K. Witkiewicz; J.R. Brody; H.Rui and K.-U. Wagner (2013): Dormant cancer cells contribute to residual disease in a mouse model for reversible pancreatic cancer. Cancer Research 73 (6): 1821-1830 [Abstract] [PDF] [Supplemental Figures and Information]

Bell, B.D.; M. Kitajima; R.P. Larson; T.A. Stoklasek; K. Dang; K. Sakamoto; K.-U. Wagner; B. Reizis; L. Hennighausen and S.F. Ziegler (2013): STAT5 is critical in Dendritic Cells for development of TH2- but not TH1-dependent Immunity.Nature Immunology 14 (4): 364-371 [Abstract] [PDF]

Kubovcakova, L.; P. Lundberg; J. Grisouard; H. Hao-Shen; V. Romanet; R. Andraos; M. Murakami; S. Dirnhofer; K.-U. Wagner; T. Radimerski, and R.C. Skoda (2013): Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood 121 (7): 1188-1199 [Abstract] [PDF]

Wagner, K.-U.; B.W. Booth; C.A. Boulanger and G.H. Smith (2013): Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis. Oncogene 32 (10): 1338 [Abstract] [PDF]

Back to top


Rachagani, S; M.P. Torres; S. Kumar; D. Harida; M. Baine; M.A. Macha; S. Kaur; M.P. Ponnusamy; P. Dey; P. Seshacharyulu; S.L. Johansson; M. Jain;  K.-U. Wagner and S.K Batra (2012): Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. J. Hematol. Oncol. 5(1):68 [Abstract] [PDF] [Open Access]

Sakamoto, K.; J.W. Schmidt and K.-U. Wagner (2012): Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. PLoS ONE 7(8): e43778 [Abstract] [PDF] [Open Access]

Sánchez-Bailóna, M.P.; A. Calcabrinia; D. Gómez-Domíngueza; B. Mortec; E. Martín-Foreroa; G. Gómez-Lópezd; A. Molinarib; K.-U. Wagner and J. Martín-Péreza (2012): Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. Cellular Signalling 24: 11276–1286 [Abstract] [PDF]

Morris, C.R.; M.J. Stanton; K.C. Manthey; K.B. Oh and K.-U. Wagner (2012): A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death. PLoS ONE 7 (3): e34308 [Abstract] [PDF] [Open Access]

Hantschel, O.; W. Warsch; E. Eckelhart; I. Kaupe; F. Grebien; K.-U. Wagner; G. Superti-Furga and V. Sexl (2012): Targeting STAT5 in CML: Mechanism-of-action of JAK2 tyrosine kinase inhibitors in CML unmasks a direct BCR-ABL/STAT5 axis. Nature Chemical Biology 8 (3): 285-293 [Abstract] [PDF]

Shi, S.Y.; R. Garcia Martin; R.E. Duncan; D. Choi; S.Y. Lu;,S.A.Schroer; E.P. Cai; C.T. Luk; K.E. Hopperton; A.F. Domenichiello; C. Tang; M. Naples; M.J. Dekker; A. Giacca; K. Adeli; K.-U.Wagner; R.P. Bazinet and M. Woo (2012): Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. J. Biol. Chem. 287 (13): 10277-10288 [Abstract] [PDF]

Hlady, R.A.; S. Novakova; J. Opavska; D. Klinkebiel; S.L. Peters; J.Bies; J. Hannah; J. Iqbal; K.M. Anderson; H.M. Siebler; L.M. Smith; T.C. Greiner; D. Bastola; S. Joshi; O. Lockridge; M.A. Simpson; D.W. Felsher; K.-U. Wagner; W.C. Chan; J.K. Christman and R. Opavsky (2012): Loss of Dnmt3b maintenance function up-regulates the novel tumor modifier Ment and accelerates mouse. lymphomagenesis. J. Clin. Invest. 122 (1): 163-177 [Abstract] [PDF]

Back to top


Schneckenleithner, C.; Z. Bago-Horvath; H. Dolznig; N. Neugebauer; K. Kollmann; T. Kolbe; T. Decker; D. Kerjaschki; K.-U.Wagner; M. Müller; D. Stoiber and V. Sexl (2011): Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget 2 (12): 1043-1054 [Abstract] [PDF]

Wagner, K.-U. and J.W. Schmidt (2011): The two faces of Janus kinases and their respective STATs in mammary gland development and cancer. Journal of Carcinogenesis 10 (32): 50-59 [Abstract] [PDF] [Open Access]

Zhang, Q.; K. Sakamoto; C. Liu; A.A. Triplett; W.C. Lin; H. Rui and K.-U. Wagner (2011): Cyclin D3 compensates for the loss of Cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Research 71 (24): 7513-7524 [Abstract] [PDF]

Tu, C.; G. Ahmad; B. Mohapatra; S. Bhattacharyya; C.F. Ortega-Cava; B.M. Chung; K.-U. Wagner; S.M. Raja; M. Naramura; V. Band and H. Band (2011): ESCRT proteins: double-edged regulators of cellular signaling. BioArchitecture 1 (1): 45-48 [Abstract] [PDF]

Pathak, S.; S. Ma; L. Trinh; J. Eudy; K.-U. Wagner; S.S. Joshi and R. Lu (2011): IRF4 is a suppressor of c-Myc induced B cell leukemia. PLoS ONE 6 (7): e22628 [Abstract] [PDF] [Open Access]

Mueller, K.M.; J.-W. Kornfeld; K. Friedbichler; L. Blaas; G. Egger; H. Esterbauer; P. Hasselblatt; M. Schlederer; S. Haindl; K.-U. Wagner; D. Engblom; G. Haemmerle; D. Kratky; V. Sexl; L. Kenner; A.V. Kozlov; L. Terracciano; R. Zechner; G. Schuetz; E. Casanova; J.A. Pospisilik; M.H. Heim and R. Moriggl (2011): Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology 54 (4): 1398-1409 [Abstract] [PDF]

Nordstrom, S.M.; J.L. Tran; B.C. Sos; K.-U. Wagner and E. J. Weiss (2011): Liver-derived IGF-1 contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH. Molecular Endocrinology 25 (7): 1223-1230 [Abstract] [PDF]

Kirabo, A.; S.P. Oh; H. Kasahara; K.-U. Wagner and P.P. Sayeski (2011): Vascular Smooth Muscle Jak2 Deletion Prevents Angiotensin II-induced Neointima Formation Following Injury in Mice. Journal of Molecular and Cellular Cardiology 50 (6): 1026-10234 [Abstract] [PDF]

Sos, B.C; C. Harris; S.M. Nordstrom; J.L. Tran; M. Balázs; P. Caplazi; M. Febbraio; M.A. Applegate; K.-U. Wagner and E.J. Weiss (2011): Profound Fatty Liver in Mice with Hepatocyte-Specific Deletion of JAK2 is Completely Rescued by Abrogation of Growth Hormone Secretion. J. Clin. Invest. 121 (4): 1412-1423 [Abstract] [PDF]

Kirabo, A.; P.N. Kearns; Y.P. Jarajapu; J.M. Sasser; S.P. Oh; M.B. Grant; H. Kasahara; A.J. Cardounel; C. Baylis; K.-U. Wagner and P.P. Sayeski (2011): Vascular Smooth Muscle Jak2 Mediates Angiotensin II-induced Hypertension via Increased Levels of Reactive Oxygen Species. Cardiovascular Research 91 (1): 171-179 [Abstract] [PDF]

Rucker, E.B.; A.N. Hale; D.C. Durtschi; K. Sakamoto and K.-U. Wagner (2011): Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax. Genesis 49 (1): 24-35 [Abstract] [PDF]

Wu S.; S. Divall; G.E. Hoffman; W.W. Le; K.-U. Wagner and A. Wolfe (2011): Jak2 is Necessary for Neuroendocrine Control of Female Reproduction. Journal of Neuroscience 31 (1): 184-192 [Abstract] [PDF]

Back to top

2009 - 2010

Choi, D.; S.A. Schroer; S.Y. Lu; L. Wang; X. Wu; Y. Liu; Y. Zhang; H.Y. Gaisano; K.-U. Wagner; H. Wo; R. Retnakaran and M. Wo (2010): Erythropoietin protects against diabetes through direct effects on pancreatic β cells. J. Exp. Med. 207 (13): 2831-2842 [Abstract] [PDF]

Rochman, Y; M. Kashyap; G.W. Robinson; K. Sakamoto; J. Gomez-Rodriguez; K.-U. Wagner and W.J. Leonard (2010): Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc. Natl. Acad. Sci. U.S.A 107 (45): 19455-19460 [Abstract] [PDF]

Tu, C.; C.F. Ortega-Cava; P. Winograd; M.J. Stanton; A.L. Reddi; I. Dodge; R. Arya; M. Dimri; R.J. Clubb; M. Naramura; K.-U. Wagner; V. Band and H. Band (2010): Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent late endosome/lysosome traffic regulates the localization of active Src at focal adhesions. Proc. Natl. Acad. Sci. U.S.A. 107 (37): 16107-16112 [Abstract] [PDF]

Sakamoto, K; A.A. Triplett; L.A. Schuler and K.-U. Wagner (2010): Jak2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 29 (39): 5359-5369 [Abstract] [PDF] [Supplementary Data]

Creamer, B.A.; K. Sakamoto; J.W. Schmidt; A.A. Triplett, R. Moriggl and K.-U. Wagner (2010): Stat5 promotes survival of mammary epithelial cell through transcriptional activation of a distinct promoter in Akt1. Mol. Cell. Biol. 30 (12): 2957–2970 [Abstract] [PDF]

Yalcin-Ozuysal, O; M. Fiche; M. Guitierrez; K.-U. Wagner; W. Raffoul and C. Brisken (2010): Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ. 17 (10): 1600–1612 [Abstract] [PDF]

Zhang, Q.; A.A. Triplett; D.W. Harms. W.C. Lin; B.A. Creamer; A. Rizzino and K.-U. Wagner (2010): Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. Transgenic Research 19 (3): 499-509 contributed equally [Abstract] [PDF] [Supplementary Data]

Sakamoto, K.; W.C. Lin; A.A. Triplett and K.-U. Wagner (2009): Targeting Jak2 in Her2/neu-expressing mammary cancer: implications for cancer prevention and therapy. Cancer Research 69 (16): 6642-6650 [Abstract] [PDF] [Supplementary Data]

Creamer, B.A.; A.A. Triplett and K.-U. Wagner (2009): Longitudinal analysis of mammogenesis using a novel tet-inducible mouse model and in vivo imaging. Genesis 47 (4): 234-245 [Abstract] [PDF]

Back to top


Triplett, A.A.; Montagna, C. and K.-U. Wagner (2008): A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis. Neoplasia 10 (12): 1325–1334 [Abstract] [PDF]

Bierie, B.; D.G. Stover; T.W. Abel; A. Chytil; A.E. Gorska; M. Aakre; E. Forrester; L. Yang; K.-U. Wagner and H.L. Moses (2008): Transforming Growth Factor- b Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment. Cancer Research 68 (6): 1809-19 [Abstract] [PDF]

Wagner, K.-U . and H. Rui (2008): Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. Journal of Mammary Gland Biology and Neoplasia 13 (1): 93-103 [Abstract] [PDF] email us to get the password to open the PDF

Lin, D.I.; M.D. Lessie; A.B. Gladden; C.H. Bassing; K.-U. Wagner and J.A. Diehl (2008): Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis. Oncogene 27 (9): 1231–1242 [Abstract] [PDF]

Back to top


Feng, Y.; D. Manka; K.-U. Wagner and S. Khan (2007): ERa expression in the mammary epithelium is required for ductal and alveolar morphogenesis in pubertal, pregnant and lactating mice. Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14718 –14723 [Abstract] [PDF]

Neilson, L.M.; J. Zhu; J. Xie; M.G. Malabarba; K. Sakamoto ; K.-U. Wagner; R.A. Kirken and H. Rui (2007): Coactivation of Jak1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Stat3 and Enhancement of Akt and Stat5a/b Pathways. Molecular Endocrinology 21 (9): 2218–2232 [Abstract] [PDF]

Pecha, J.; D. Ankrapp; C. Jiang; W. Tang; K. Bruck; K.-U. Wagner and H. Xiao (2007): Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland. Oncogene 26 (53): 7423-7431 [Abstract] [PDF]

Sakamoto, K; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2007): The Janus kinase 2 (Jak2) is required for expression and nuclear accumulation of Cyclin D1 in proliferating mammary epithelial cells. Molecular Endocrinology 21 (8): 1877-1892 [Abstract] [PDF]

Oh, K.B.; M.J. Stanton; W.W. West; G.L. Todd and K.-U. Wagner (2007): Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene 26 (40): 5950–5959 [Abstract] [PDF]

Matulka, L.A.; A.A. Triplett and K.-U. Wagner (2007): Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Developmental Biology 303 (1): 29–44 [Abstract] [PDF]

Back to top

2005 - 2006

Loladze A.V.; M.A. Stull; A.M. Rowzee; J. Demarco; J.H. Lantry, 3 rd; C.J. Rosen; D. Leroith; K.-U. Wagner; L. Hennighausen and T.L Wood (2006): Epithelial-Specific and Stage-Specific Functions of IGF-I during Postnatal Mammary Development. Endocrinology 147 (11): 5412-5423 [Abstract] [PDF]

Utama, F.E.; M.J. LeBaron; L.M Neilson; A.S. Sultan; A.F. Parlow; K.-U. Wagner and H. Rui (2006): Human prolactin receptors are insensitive to mouse prolactin: Implications for xenotransplant modeling of human breast cancer in mice. Journal of Endocrinology 188 (3): 589-601 [Abstract] [PDF]

Triplett, A.A.; K. Sakamoto; L.A. Matulka; L. Shen; G.H. Smith and K.-U. Wagner (2005): Expression of the Whey Acidic Protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. Genesis 43 (1): 1-11 [Abstract] [PDF]

Matulka, L.A. and K.-U. Wagner (2005): Models of Breast Cancer. Drug Discovery Today: Disease Models 2 (1): 1-6 [PDF]

Wagner, K.-U. and G. H. Smith (2005): Pregnancy and Stem Cell Behavior. Journal of Mammary Gland Biology and Neoplasia 10 (1): 25-36 [Abstract] [PDF]

Sum, E.Y.M.; M. Shackleton; L.A. O’Reilly; K. Hahm; N.K. Jonas; K.-U. Wagner; G.J. Lindeman and J.E. Visvader (2005): The LIM domain protein Lmo4 is highly expressed in epithelial tissues and influences lobuloalveolar development in the mammary gland. Oncogene 24 (30): 4820-4828 [Abstract] [PDF]

Boulanger , C.A. ; K.-U. Wagner and G.H. Smith (2005): Parity-induced mouse mammary epithelial cells (PI-MEC) are pluripotent, self-renewing and sensitive to TGF-b1 expression. Oncogene 24 (4): 552-560 [Abstract] [PDF]

Back to top


Sgagias, M.K.; K.-U. Wagner; B. Hamik; S. Stoeger ; R. Spieker; L.J. Huber; L.A. Chodosh and K.H. Cowan (2004): Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS. Cell Cycle 3 (11): 1451-1456 [Abstract] [PDF]

Krempler, A.; Y. Qi; A.A. Triplett; J. Zhu; H. Rui and K.-U. Wagner (2004): Generation of a conditional knockout allele for the Janus Kinase 2 (Jak2) gene in mice. Genesis 40 (1):52-57 [Abstract] [PDF]

Henry, M.D.; A.A. Triplett; K.B. Oh; G.H. Smith and K.-U. Wagner (2004): Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice. Oncogene 23 (41): 6980–6985 [Abstract] [PDF]

Carstens; M.J.; A. Krempler; A.A. Triplett; M. van Lohuizen and K.-U. Wagner (2004): Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J. Biol. Chem. 279 (34): 35984-35994 [Abstract] [PDF]

Wagner, K.-U.; A. Krempler; A.A. Triplett, Y. Qi; N.M. George; J. Zhu and H. Rui (2004): Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol. Cell. Biol. 24 (12): 5510-5520 [Abstract] [PDF]

Cheung, A.M.Y.; A. Elia; M.-S. Tsao; S. Done; K.-U. Wagner; L. Hennighausen; R. Hakem and T.W. Mak (2004): Brca2 deficiency does not impair mammary gland development but promotes the development of mammary adenocarcinomas in p53+/- mutant mice. Cancer Research 64 (6): 1959-1965 [Abstract] [PDF]

Backman, S.A.; D. Ghazarian; K. So; O. Sanchez; K.-U.Wagner; L. Hennighausen; A. Suzuki; M.S. Tsao; W.B. Chapman; Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, Hennighausen L, Suzuki A, Tsao MS, Chapman WB, Stambolic V, Mak TW. Stambolic and T.W. Mak (2004): Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1725-1730 [Abstract] [PDF]

Wagner, K.-U. (2004): Quo Vadis, Animal Modeling? Breast Cancer Research 6 (1): 31-38 (online 31 October 2003) [Abstract] [PDF]

Back to top


Long, W.; K.-U. Wagner; K.C.K. Lloyd; L.N. Binart; J. M. Shillingford; L. Hennighausen and F.E. Jones (2003):
Impaired mammopoiesis and Stat5 activation in mice with conditional ErbB4 mutations. Development 130 (21): 5257-5268 [Abstract] [PDF]

Bierie, B.; M. Nozawa; J.-P. Renou; J. M. Shillingford; F. Morgan; T. Oka; M. M. Taketo; R. D. Cardiff; K. Miyoshi; K.-U. Wagner; G. W. Robinson and Lothar Hennighausen (2003): Activation of b-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene 22 (25): 3875-3887 [Abstract] [PDF]

Seagroves T.N.; D. Hadsell; J. McMananman; C. Palmer; D. Liao; W. McNulty; B. Welm; K.-U. Wagner; M. Neville and R..S. Johnson (2003): HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130 (8): 1713-1724 [Abstract] [PDF]

Wagner, K.-U., A. Krempler, Y. Qi, K. Park, M. D. Henry, A. A. Triplett, G. Riedlinger, E. B. Rucker III, and L. Hennighausen (2003): Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol. Cell. Biol. 23 (1): 150-162 [Abstract] [PDF]

Back to top


Krempler, A.; M. D. Henry; A. A. Triplett and K.-U. Wagner (2002): Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53 independent cell death. J. Biol. Chem. 277 (45): 43216-43223 [Abstract] [PDF]

Li, G.; G.W Robinson; R. Lesche; H. Martinez-Diaz; Z. Jiang; N. Rozengurt; K.-U. Wagner; D.C. Wu; T.F. Lane; X. Liu; L. Hennighausen and H. Wu (2002): Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129 (17): 4159-4170 [Abstract] [PDF]

Nevalainen, M. T.; J. Xie; L. Bubendorf; K.-U. Wagner and H. Rui (2002): Basal activation of transcription factor Stat5 in nonpregnant mouse and human breast epithelium. Molecular Endocrinology 16 (5): 1108-1124 [Abstract] [PDF]

Cui Y.; K. Miyoshi; E. Claudio; T. Oka; U.K. Siebenlist; F.J. Gonzalez; J. Flaws; K.-U. Wagner; and L. Hennighausen (2002): Loss of the peroxisome proliferation-activated receptor gamma does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J. Biol. Chem. 277 (20): 17830-17835 [Abstract] [PDF]

Wagner, K.-U.; C. A. Boulanger; M. D. Henry; M. Sgagias, L. Hennighausen, and G. H. Smith (2002): An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. Development 129 (6): 1377-1386 [Abstract] [PDF]

Riedlinger, G.; R. Okagaki; K. Miyoshi, K.-U. Wagner; E. B. Rucker; T. Oka; J. A. Flaws, and L. Hennighausen (2002): The role of Bcl-x in the survival and maintenance of follicles, granulosa cells and the corpus luteum. Biology of Reproduction 66 (2): 438-444 [Abstract] [PDF]

Back to top


Miyoshi, K.; J. Shillingford; G. H. Smith; S. Grimm; K.-U. Wagner; T. Oka; J. M. Rosen; G. W. Robinson and L. Hennighausen (2001): Signal Transducer and Activator Transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. Journal of Cell Biology 155 (4): 531-542 [Abstract] [PDF]

Walton K. D., K.-U. Wagner, E. B. Rucker, J. M. Shillingford, and L. Hennighausen (2001): Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. Mechanisms of Development 109 (2): 281-293 [Abstract] [PDF]

Robinson, G.W.; K.-U. Wagner; and L. Hennighausen (2001): Functional mammary gland development and tumor formation are not affected by the absence of the retinoblastoma gene. Oncogene 20 (48): 7115-7119 [Abstract] [PDF]

Wagner, K.-U.; K. McAllister; T. Ward; B. Davis; R. Wiseman and L. Hennighausen (2001): Spatial and temporal expression of the Cre gene under the control of the MMTV LTR in different transgenic lines. Transgenic Research 10 (6): 545-553 [Abstract] [PDF]

Yamashita H., M. T. Nevalainen, J. Xu, M. J. LeBaron, K.-U. Wagner, R. A. Erwin, J. M. Harmon, L. Hennighausen, R. A. Kirken, and H. Rui (2001): Role of serine phosphorylation of Stat5a in prolactin-stimulated b-casein gene expression. Molecular and Cellular Endocrinology 183 (1-2): 151-63 [Abstract] [PDF]

Back to top

1999 - 2000

Wagner, K.-U.; E. Claudio; E.B. Rucker III; G. Riedlinger; C. Broussard; P. L. Schwarzberg; U. Siebenlist and L. Hennighausen (2000): Conditional deletion of the bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127 (22): 4949-4958 [Abstract] [PDF]

Rucker. E.B. III, P. Dierisseau, K.-U. Wagner, L. Garrett, A. Wynshaw-Boris, J. A. Flaws and L. Hennighausen (2000): Survival of primordial germ cells during mouse embryogenesis is dependent on Bcl-x. Molecular Endocrinology 14 (7): 1038-1052 [Abstract] [PDF]

Xu X., K.-U. Wagner, D. Larson, Z. Weaver, C. Li, T. Ried, L. Hennighausen, A. Wynshaw-Boris, and C.-X. Deng (1999): Conditional knockout of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation. Nature Genetics 22 (1): 37-43 [Abstract] [PDF]

Wagner, K.-U.; Dierisseau, P. and L. Hennighausen (1999): Assignment of the murine tumor susceptibility gene 101 (tsg101) and a processed tsg101 pseudogene (tsg101-ps1) to mouse chromosome 7 band B5 and chromosome 15 band D1 by in situ hybridization. Cytogenet Cell Genet 84 (1-2): 87-88 [Abstract] [PDF]

Back to top

1996 - 1998

Wagner, K.-U.; Dierisseau, P.; Rucker, E.B., III; Robinson, G. W. and L. Hennighausen (1998): Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants. Oncogene 17 (21): 2761-2770 [Abstract] [PDF]

Young, W.S.; Shepard, E.; DeVries, A.C.; Zimmer, A.; LaMarca, M.E.; Ginns, E.I.; Amico, J.; Nelson, R.J.; Hennighausen, L. and K.-U. Wagner (1998): Targeted reduction of oxytocin expression provides insights into its physiological roles (Review). Adv. Exp. Med. Biol. 449: 231-240 [Abstract]

Wagner, K.-U.; W. S. Young; X. Liu; E. I. Ginns; M. Li; P. A. Furth and L. Hennighausen (1997): Oxytocin and milk removal are required for post-partum mammary gland development. Genes and Function 1 (4): 233-244 [Abstract] [PDF]

Wagner, K.-U.; R.J. Wall; L. St-Onge; P. Gruss; A. Wynshaw-Boris; M. Li; P.A. Furth and L. Hennighausen (1997): Cre mediated gene deletion in the mammary gland. Nucleic Acids Res. 25 (21): 4323-4330 [Abstract] [PDF]

Hennighausen, L.; G. W. Robinson, K.-U. Wagner and X. Liu (1997): Developing a mammary gland is a Stat(e) affair (Review). Journal of Mammary Gland Biology and Neoplasia 2 (4): 365-371 [Abstract] [PDF]

Hennighausen, L.; G. W. Robinson, K.-U. Wagner and X. Liu (1997): Prolactin Signalling in Mammary Gland Development (Review). J. Biol. Chem. 272 (12): 7567-7569 [Abstract] [PDF]

Li, M.; X. Liu; G. W. Robinson; U. Bar-Peled; K.-U. Wagner; W. S. Young; E. I. Ginns; L. Hennighausen and P. A. Furth (1997): Mammary derived signals activate programmed cell death in the involuting gland. Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3425-3430 [Abstract] [PDF]

Liu X.; .G.W. Robinson; K.-U. Wagner; L. Garrett; A. Wynshaw-Boris and Lothar Hennighausen (1997): Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes and Development 11 (2): 179-186 [Abstract] [PDF]

Young, W.S.; E. Shepard; J. Amico; L. Hennighausen; K.-U. Wagner; M.E. LaMarca; C. McKinney and E.I. Ginns (1996): Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J. Neuroendocrinol. 8 (11): 847-853 [Abstract] [PDF]

Back to top

Book Chapters:

Schmidt, J.W. and K.-U. Wagner (2012):  Activation of Janus Kinases During Tumorigenesis in “Jak-Stat Signaling: From Basics to Disease”; edited by Decker, T. and Muller, M., Springer Publishing, ISBN: 978-3-7091-0890-1, Pgs. 259-288 

Amit, I.; K.-U. Wagner and Y. Yarden (2005): Molecular functions of Tsg101. Chapter 1 in “Second Messengers and Phosphoprotein Signaling”; pp 1-11; edited by M.B. Anand-Srivastava, M. Tremblay, and A.K. Srivastava; Medimont S.r.l., Bologna, Italy

Wagner, K.-U., E. B. Rucker III and L. Hennighausen (2000): Adenoviral and transgenic approaches for the conditional deletion of genes from mammary tissue. Chapter 24 in "Methods in mammary gland biology and breast cancer"; pp 271-288; edited by Ip, M.M. and Asch, B.B.; Kluwer Academic/Plenum Publishers, New York; ISBN: 0-306-46397-0. [PDF]

Li, M., K.-U. Wagner, and P.A. Furth (2000): Transfection of primary mammary epithelial cells by viral and nonviral methods. Chapter 21 in "Methods in mammary gland biology and breast cancer"; pp 233-244; edited by Ip, M.M. and Asch, B.B.; Kluwer Academic/Plenum Publishers, New York; ISBN: 0-306-46397-0.

Back to top