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PublicationsSelected Articles: [2007] [2005/06] [2004] [2003] [2002] [2001] [1999/2000] [1996-98] [Books] 2008 Creamer, B.A.; A.A. Triplett and K.-U. Wagner (2008): Longitudinal analysis of mammogenesis using a novel tet-inducible mouse model and in vivo imaging. Genesis, in press Triplett, A.A.; Montagna, C. and K.-U. Wagner (2008): A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis. Neoplasia, in press Bierie, B.; D.G. Stover; T.W. Abel; A. Chytil; A.E. Gorska; M. Aakre; E. Forrester; L. Yang; K.-U. Wagner and H.L. Moses (2008): Transforming Growth Factor- b Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment. Cancer Research 68 (6): 1809-19 [Abstract] [PDF] Wagner, K.-U . and H. Rui (2008): Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. Journal of Mammary Gland Biology and Neoplasia 13 (1): 93-103 [Abstract] [PDF] email us to get the password to open the PDF Lin, D.I.; M.D. Lessie; A.B. Gladden; C.H. Bassing; K.-U. Wagner and J.A. Diehl (2008): Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis. Oncogene 27 (9): 1231–1242 (Epub 2007 Aug 27) [Abstract] [PDF] Feng, Y.; D. Manka; K.-U. Wagner and S. Khan (2007): ERa expression in the mammary epithelium is required for ductal and alveolar morphogenesis in pubertal, pregnant and lactating mice. Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14718 –14723 [Abstract] [PDF] Neilson, L.M.; J. Zhu; J. Xie; M.G. Malabarba; K. Sakamoto ; K.-U. Wagner; R.A. Kirken and H. Rui (2007): Coactivation of Jak1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Stat3 and Enhancement of Akt and Stat5a/b Pathways. Molecular Endocrinology 21 (9): 2218–2232 [Abstract] [PDF] Pecha, J.; D. Ankrapp; C. Jiang; W. Tang; K. Bruck; K.-U. Wagner and H. Xiao (2007): Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland. Oncogene 26 (53): 7423-7431 [Abstract] [PDF] Sakamoto, K; B.A. Creamer; A.A. Triplett and K.-U. Wagner (2007): The Janus kinase 2 (Jak2) is required for expression and nuclear accumulation of Cyclin D1 in proliferating mammary epithelial cells. Molecular Endocrinology 21 (8): 1877-1892 [Abstract] [PDF] Oh, K.B.; M.J. Stanton; W.W. West; G.L. Todd and K.-U. Wagner (2007): Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene 26 (40): 5950–5959 [Abstract] [PDF] Matulka, L.A.; A.A. Triplett and K.-U. Wagner (2007): Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Developmental Biology 303 (1): 29–44 [Abstract] [PDF] Loladze A.V.; M.A. Stull; A.M. Rowzee; J. Demarco; J.H. Lantry, 3 rd; C.J. Rosen; D. Leroith; K.-U. Wagner; L. Hennighausen and T.L Wood (2006): Epithelial-Specific and Stage-Specific Functions of IGF-I during Postnatal Mammary Development. Endocrinology 147 (11): 5412-5423 [Abstract] [PDF] Utama, F.E.; M.J. LeBaron; L.M Neilson; A.S. Sultan; A.F. Parlow; K.-U. Wagner and H. Rui (2006): Human prolactin receptors are insensitive to mouse prolactin: Implications for xenotransplant modeling of human breast cancer in mice. Journal of Endocrinology 188 (3): 589-601 [Abstract] [PDF] Triplett, A.A.; K. Sakamoto; L.A. Matulka; L. Shen; G.H. Smith and K.-U. Wagner (2005): Expression of the Whey Acidic Protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. Genesis 43 (1): 1-11 [Abstract] [PDF] Matulka, L.A. and K.-U. Wagner (2005): Models of Breast Cancer. Drug Discovery Today: Disease Models 2 (1): 1-6 [PDF] Wagner, K.-U. and G. H. Smith (2005): Pregnancy and Stem Cell Behavior. Journal of Mammary Gland Biology and Neoplasia 10 (1): 25-36 [Abstract] [PDF] Sum, E.Y.M.; M. Shackleton; L.A. O’Reilly; K. Hahm; N.K. Jonas; K.-U. Wagner; G.J. Lindeman and J.E. Visvader (2005): The LIM domain protein Lmo4 is highly expressed in epithelial tissues and influences lobuloalveolar development in the mammary gland. Oncogene 24 (30): 4820-4828 [Abstract] [PDF] Boulanger , C.A. ; K.-U. Wagner and G.H. Smith (2005): Parity-induced mouse mammary epithelial cells (PI-MEC) are pluripotent, self-renewing and sensitive to TGF-b1 expression. Oncogene 24 (4): 552-560 [Abstract] [PDF] Sgagias, M.K.; K.-U. Wagner; B. Hamik; S. Stoeger ; R. Spieker; L.J. Huber; L.A. Chodosh and K.H. Cowan (2004): Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS. Cell Cycle 3 (11): 1451-1456 [Abstract] [PDF] Krempler, A.; Y. Qi; A.A. Triplett; J. Zhu; H. Rui and K.-U. Wagner (2004): Generation of a conditional knockout allele for the Janus Kinase 2 (Jak2) gene in mice. Genesis 40 (1):52-57 [Abstract] [PDF] Henry, M.D.; A.A. Triplett; K.B. Oh; G.H. Smith and K.-U. Wagner (2004): Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice. Oncogene 23 (41): 6980–6985 [Abstract] [PDF] Carstens; M.J.; A. Krempler; A.A. Triplett; M. van Lohuizen and K.-U. Wagner (2004): Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J. Biol. Chem. 279 (34): 35984-35994 [Abstract] [PDF] Wagner, K.-U.; A. Krempler; A.A. Triplett, Y. Qi; N.M. George; J. Zhu and H. Rui (2004): Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol. Cell. Biol. 24 (12): 5510-5520 [Abstract] [PDF] Cheung, A.M.Y.; A. Elia; M.-S. Tsao; S. Done; K.-U. Wagner; L. Hennighausen; R. Hakem and T.W. Mak (2004): Brca2 deficiency does not impair mammary gland development but promotes the development of mammary adenocarcinomas in p53+/- mutant mice. Cancer Research 64 (6): 1959-1965 [Abstract] [PDF] Backman, S.A.; D. Ghazarian; K. So; O. Sanchez; K.-U.Wagner; L. Hennighausen; A. Suzuki; M.S. Tsao; W.B. Chapman; Backman SA, Ghazarian D, So K, Sanchez O, Wagner KU, Hennighausen L, Suzuki A, Tsao MS, Chapman WB, Stambolic V, Mak TW. Stambolic and T.W. Mak (2004): Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1725-1730 [Abstract] [PDF] Wagner, K.-U. (2004): Quo Vadis, Animal Modeling? Breast Cancer Research 6 (1): 31-38 (online 31 October 2003) [Abstract] [PDF] Long, W.; K.-U. Wagner; K.C.K. Lloyd; L.N. Binart; J. M. Shillingford;
L. Hennighausen and F.E. Jones (2003): Bierie, B.; M. Nozawa; J.-P. Renou; J. M. Shillingford; F. Morgan; T. Oka; M. M. Taketo; R. D. Cardiff; K. Miyoshi; K.-U. Wagner; G. W. Robinson and Lothar Hennighausen (2003): Activation of b-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene 22 (25): 3875-3887 [Abstract] [PDF] Seagroves T.N.; D. Hadsell; J. McMananman; C. Palmer; D. Liao; W. McNulty; B. Welm; K.-U. Wagner; M. Neville and R..S. Johnson (2003): HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130 (8): 1713-1724 [Abstract] [PDF] Wagner, K.-U., A. Krempler, Y. Qi, K. Park, M. D. Henry, A. A. Triplett, G. Riedlinger, E. B. Rucker III, and L. Hennighausen (2003): Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol. Cell. Biol. 23 (1): 150-162 [Abstract] [PDF] Krempler, A.; M. D. Henry; A. A. Triplett and K.-U. Wagner (2002): Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53 independent cell death. J. Biol. Chem. 277 (45): 43216-43223 [Abstract] [PDF] Li, G.; G.W Robinson; R. Lesche; H. Martinez-Diaz; Z. Jiang; N. Rozengurt; K.-U. Wagner; D.C. Wu; T.F. Lane; X. Liu; L. Hennighausen and H. Wu (2002): Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129 (17): 4159-4170 [Abstract] [PDF] Nevalainen, M. T.; J. Xie; L. Bubendorf; K.-U. Wagner and H. Rui (2002): Basal activation of transcription factor Stat5 in nonpregnant mouse and human breast epithelium. Molecular Endocrinology 16 (5): 1108-1124 [Abstract] [PDF] Cui Y.; K. Miyoshi; E. Claudio; T. Oka; U.K. Siebenlist; F.J. Gonzalez; J. Flaws; K.-U. Wagner; and L. Hennighausen (2002): Loss of the peroxisome proliferation-activated receptor gamma does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J. Biol. Chem. 277 (20): 17830-17835 [Abstract] [PDF] Wagner, K.-U.; C. A. Boulanger; M. D. Henry; M. Sgagias, L. Hennighausen, and G. H. Smith (2002): An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. Development 129 (6): 1377-1386 [Abstract] [PDF] Riedlinger, G.; R. Okagaki; K. Miyoshi, K.-U. Wagner; E. B. Rucker; T. Oka; J. A. Flaws, and L. Hennighausen (2002): The role of Bcl-x in the survival and maintenance of follicles, granulosa cells and the corpus luteum. Biology of Reproduction 66 (2): 438-444 [Abstract] [PDF] Miyoshi, K.; J. Shillingford; G. H. Smith; S. Grimm; K.-U. Wagner;
T. Oka; J. M. Rosen; G. W. Robinson and L. Hennighausen (2001):
Signal Transducer and Activator Transcription (Stat) 5 controls
the proliferation and differentiation of mammary alveolar epithelium.
Journal of Cell Biology 155 (4): 531-542 [Abstract]
[PDF]
Robinson, G.W.; K.-U. Wagner; and L. Hennighausen (2001): Functional mammary gland development and tumor formation are not affected by the absence of the retinoblastoma gene. Oncogene 20 (48): 7115-7119 [Abstract] [PDF] Wagner, K.-U.; K. McAllister; T. Ward; B. Davis; R. Wiseman and L. Hennighausen (2001): Spatial and temporal expression of the Cre gene under the control of the MMTV LTR in different transgenic lines. Transgenic Research 10 (6): 545-553 [Abstract] [PDF] Yamashita H., M. T. Nevalainen, J. Xu, M. J. LeBaron, K.-U. Wagner, R. A. Erwin, J. M. Harmon, L. Hennighausen, R. A. Kirken, and H. Rui (2001): Role of serine phosphorylation of Stat5a in prolactin-stimulated b-casein gene expression. Molecular and Cellular Endocrinology 183 (1-2): 151-63 [Abstract] [PDF] Wagner, K.-U.; E. Claudio; E.B. Rucker III; G. Riedlinger; C. Broussard; P. L. Schwarzberg; U. Siebenlist and L. Hennighausen (2000): Conditional deletion of the bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127 (22): 4949-4958 [Abstract] [PDF] Rucker. E.B. III, P. Dierisseau, K.-U. Wagner, L. Garrett, A. Wynshaw-Boris, J. A. Flaws and L. Hennighausen (2000): Survival of primordial germ cells during mouse embryogenesis is dependent on Bcl-x. Molecular Endocrinology 14 (7): 1038-1052 [Abstract] [PDF] Xu X., K.-U. Wagner, D. Larson, Z. Weaver, C. Li, T. Ried, L. Hennighausen, A. Wynshaw-Boris, and C.-X. Deng (1999): Conditional knockout of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation. Nature Genetics 22 (1): 37-43 [Abstract] [PDF] Wagner, K.-U.; Dierisseau, P. and L. Hennighausen (1999): Assignment of the murine tumor susceptibility gene 101 (tsg101) and a processed tsg101 pseudogene (tsg101-ps1) to mouse chromosome 7 band B5 and chromosome 15 band D1 by in situ hybridization. Cytogenet Cell Genet 84 (1-2): 87-88 [Abstract] [PDF] Wagner, K.-U.; Dierisseau, P.; Rucker, E.B., III; Robinson, G. W. and L. Hennighausen (1998): Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants. Oncogene 17 (21): 2761-2770 [Abstract] [PDF] Young, W.S.; Shepard, E.; DeVries, A.C.; Zimmer, A.; LaMarca, M.E.; Ginns, E.I.; Amico, J.; Nelson, R.J.; Hennighausen, L. and K.-U. Wagner (1998): Targeted reduction of oxytocin expression provides insights into its physiological roles (Review). Adv. Exp. Med. Biol. 449: 231-240 [Abstract] Wagner, K.-U.; W. S. Young; X. Liu; E. I. Ginns; M. Li; P. A. Furth and L. Hennighausen (1997): Oxytocin and milk removal are required for post-partum mammary gland development. Genes and Function 1 (4): 233-244 [Abstract] [PDF] Wagner, K.-U.; R.J. Wall; L. St-Onge; P. Gruss; A. Wynshaw-Boris; M. Li; P.A. Furth and L. Hennighausen (1997): Cre mediated gene deletion in the mammary gland. Nucleic Acids Res. 25 (21): 4323-4330 [Abstract] [PDF] Hennighausen, L.; G. W. Robinson, K.-U. Wagner and X. Liu (1997): Developing a mammary gland is a Stat(e) affair (Review). Journal of Mammary Gland Biology and Neoplasia 2 (4): 365-371 [Abstract] [PDF] Hennighausen, L.; G. W. Robinson, K.-U. Wagner and X. Liu (1997): Prolactin Signalling in Mammary Gland Development (Review). J. Biol. Chem. 272 (12): 7567-7569 [Abstract] [PDF] Li, M.; X. Liu; G. W. Robinson; U. Bar-Peled; K.-U. Wagner; W. S. Young; E. I. Ginns; L. Hennighausen and P. A. Furth (1997): Mammary derived signals activate programmed cell death in the involuting gland. Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3425-3430 [Abstract] [PDF] Liu X.; .G.W. Robinson; K.-U. Wagner; L. Garrett; A. Wynshaw-Boris and Lothar Hennighausen (1997): Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes and Development 11 (2): 179-186 [Abstract] [PDF] Young, W.S.; E. Shepard; J. Amico; L. Hennighausen; K.-U. Wagner; M.E. LaMarca; C. McKinney and E.I. Ginns (1996): Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J. Neuroendocrinol. 8 (11): 847-853 [Abstract] [PDF] Amit, I.; K.-U. Wagner and Y. Yarden (2005): Molecular functions of Tsg101. Chapter 1 in “Second Messengers and Phosphoprotein Signaling”; pp 1-11; edited by M.B. Anand-Srivastava, M. Tremblay, and A.K. Srivastava; Medimont S.r.l., Bologna, Italy Wagner, K.-U., E. B. Rucker III and L. Hennighausen (2000): Adenoviral and transgenic approaches for the conditional deletion of genes from mammary tissue. Chapter 24 in "Methods in mammary gland biology and breast cancer"; pp 271-288; edited by Ip, M.M. and Asch, B.B.; Kluwer Academic/Plenum Publishers, New York; ISBN: 0-306-46397-0. [PDF] Li, M., K.-U. Wagner, and P.A. Furth (2000):
Transfection of primary mammary epithelial cells by viral and nonviral
methods. Chapter 21 in "Methods in mammary gland biology and
breast cancer"; pp 233-244; edited by Ip, M.M. and Asch, B.B.;
Kluwer Academic/Plenum Publishers, New York; ISBN: 0-306-46397-0. |