Dr. Pendyala's Laboratory








NIH/NIDA R01DA046852 
Award Period: 09/30/2018-08/31/2023 
Title: “Extracellular vesicles, meth relapse and sex differences” 
Role: Principal Investigator 

NIH/NIDA R21DA049577 
Award Period: 09/30/2019-08/31/2021  
Title: “High-throughput Integrated Magneto-electrochemical Exosome (HiMEX) platform to identify neurodevelopmental markers associated with pre and postnatal oxycodone exposure” 
Role: Principal Investigator 

NIH/NEI R01EY030507  
Award Period: 09/01/2019-05/31/2024 
Title: “Influence of Ocular hypertension on neurons and synapses in the visual thalamus” 
Role: Co-Investigator (PI: Matthew Van Hook, Ph.D., UNMC) 

UARC FA4600-12-D-9000, NU/NSRI Department of Defense 
Award Period: 01/01/2020-12/31/2024 
Title: “Acute Radiation Syndrome (ARS)” 
Role: Co-Investigator (PI: Bayles and Berkowitz) 

NIH/NIDA R21DA046284 
Award Period: 04/15/2019-03/31/2021 *No cost extension till 3/31/2022.  
Title: “Therapeutic efficacy of Ibudilast to attenuate inflammation at the synapse in HAND” 
Role: Principal Investigator 

Collaboration Initiative (2020-2021 RFA)-Team Seed Grants – Nebraska Foundation 
Award Period: 07/01/2021-06/30/2023 
Title: “Strategies to mitigate intergenerational prescription opioid abuse” 
Role: Principal Investigator 

Collaboration Initiative (2020-2021 RFA)-Preliminary Data & Application Preparation Grants - Nebraska Foundation 
Award Period: 07/01/2021-06/30/2022 
Title: “Maternal/Infant Microbiome in Rural Populations” 
Role: Co-Investigator and Mentor (PI: Moore) 

Collaboration Initiative (2020-2021 RFA)-Preliminary Data & Application Preparation Grants - Nebraska Foundation 
Award Period: 07/01/2021-06/30/2022 
Title: “Omega 3- fatty acid: Potential for mitigation of neurodevelopmental outcomes from in utero opioid exposure in a chronic stress rat model” 
Role: Co-Investigator (PI: Anderson-Berry) 

Children’s Health Research Institute- Children’s Hospital and Medical Center/UNMC       
Award Period: 07/01/2020-06/30/2022 
Title: “Cord blood extracellular vesicle proteins as novel biomarkers to screen newborns exposed to intrauterine prescription opioids”  
Role: Principal Investigator 

Children’s Health Research Institute- Children’s Hospital and Medical Center/UNMC       
Award Period: 07/01/2020-06/30/2022 
Title: “The conundrum of opioid use in the NICU: Providing comfort or aggravating development”  
Role: Co-Investigator and Mentor (PI: Sualy)  

COBRE - Rural Drug Addiction Research Center, Pilot grant 
Award Period: 07/01/2021-06/31/2023 
Title: “Sex specific brain derived extracellular vesicle markers associated with chronic methamphetamine use disorder” 
Role: Co-Investigator (PI: Yelamanchili, UNMC) 

Collaboration Initiative (2020-2021 RFA)-Team Formation and Publication Grant  
Award Period: 07/01/2021-06/30/2022 
Title: “Healthcare Disparities and Experiences of Stressors in Women During Their Pregnancy Lifecycle” 
Role: Co-Investigator (PI: Blount) 

State of NE, Dept. of Health and Human Service (LB506)  
Award Period:  07/01/21-06/30/22 
Title: “Sex specific brain derived EVs as potential markers for nicotine addiction” 
Role: Co-Investigator (PI: Yelamanchili) 

Gurudutt Pendyala, PhD, and Vicki Schaal, MS, prepare research materials in Dr. Pendyala's lab.

(Past two years)

Guda R, Tan C, Schaal VL, Yelamanchili SV and Pendyala, G (2021) “Integrated systems analysis of mixed neuroglial cultures post oxycodone exposure International Journal of Molecular Sciences 22, 6421. https://doi.org/10.3390/ ijms22126421. PMID: 34203972 

Doke, M, Pendyala G and Thangavel S (2021) “Psychostimulants and Opioids Differentially Influence the Epigenetic Modification of Histone Acetyltransferase and Histone Deacetylase” PLoS One Jun 11;16(6):e0252895. doi: 10.1371/journal.pone.0252895. eCollection 2021. PMID: 34115777 

Odegaard K, Pendyala G and Yelamanchili SV (2021). “Generational effects of opioid exposure”. Encyclopedia 1(1), 99-114  https://doi.org/10.3390/encyclopedia1010012 

Kumar S, Pendyala, G, Yelamanchili SV, Seth P, Maggirwar S, Bidlack JM and Chang SL (2021) “Society on Neuroimmune Pharmacology COVID-19 Virtual Workshop”. J Neuroimmune Pharmacology Jun 28:1-12. doi: 10.1007/s11481-021-10001-y. PMID: 34181181 

Odegaard K, Schaal VL, Clark A, Koul S, Sankarasubramanian J, Xia Z, Mellon M, Uberti M, Liu Y, Stothert A, Van Hook M, Wang H, Guda C, Lisco SJ, Pendyala G# and Yelamanchili SV (2021). “A holistic systems approach to characterize the impact of pre- and post-natal oxycodone exposure on neurodevelopment and behavior” Frontiers in Cell and Developmental Biology, DOI: 10.3389/fcell.2020.619199. PMID: 33490084 

Gowen A, Odegaard KE, Hernandez J, Chand S, Koul S, Pendyala G# and Yelamanchili SV (2021). “Role of microRNAs in the pathophysiology of addiction”. WIRES RNA Dec 17:e1637. doi: 10.1002/wrna.1637. PMID: 33336550 

Odegaard K, Chand S, Wheeler S, Tiwari S, Flores A, Hernandez J, Savine M, Gowen A, Pendyala G and Yelamanchili SV (2020). “Role of extracellular vesicles in substance abuse and neurological pathologies”. International Journal of Molecular Sciences Sep 15;21(18):6765. doi: 10.3390/ijms21186765. PMID: 32942668  

Odegaard K, Schaal VL, Clark A, Koul S, Gowen A, Sankarasubramanian J, Xiao P, Guda C, Lisco SJ, Yelamanchili SV and Pendyala G# (2020). “Characterization of the intergenerational impact of in utero and postnatal oxycodone exposure”. Translational Psychiatry Sep 23; 10(1), 329, doi.org/10.1038/s41398-020-01012-z. PMID: 32968044 

Chand S, Jo A, Veliichirammal NN, Gowen A, Guda C, Schaal V, Odegaard K, Lee H, Pendyala G and Yelamanchili SV (2020) “Comprehensive characterization of organ-specific extracellular vesicle protein markers: Implications for preclinical and clinical applications”. ACS Applied Nanomaterials 8906-8919, doi:10.1021/acsanm.0c01654 (2020). PMID: In Progress 

Koul S, Schaal VL, Chand S, Pittenger ST, Vellichirammal NN, Kumar V, Guda C, Bevins RA, Yelamanchili SV and Pendyala G# (2020). “Role of brain derived extracellular vesicles in decoding sex differences associated with nicotine self-administration”. Cells 9(8), 1883; doi: 10.3390/cells9081883. PMID: 327967722 

Additional Publications in Pubmed. 




UNMC Anesthesiology Research