RESEARCH INTERESTS
- Neuroinflammation associated with long-term use of psychostimulant drugs (methamphetamine, nicotine) at the synapse
- Prenatal drug exposure and synaptic development
- Application of novel anti-inflammatory drugs to attenuate inflammation at the synapse
- Sex differences and drug abuse
- Molecular mechanisms of microRNAs at the synapse
- Role of extracellular vesicles in drug addiction and HIV infection
LAB PERSONNEL
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Vicki Schaal |
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Sneh Koul |
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Sneham Tiwari, Ph.D. |
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Melissa Campbell |
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Gabriel Gallegos, MD Clinical Researcher |
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Kunal Sualy, MD Clinical Researcher |
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Adrian Flores Graduate Student |
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Jordan Hernandez Graduate Student |
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Melody Nguyen Graduate Student |
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Rahul Guda Undergraduate Researcher |
Lab Alumni
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Nate Lombardo |
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Nate Zaroban |
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Sid Gillella High School Researcher |
(no image available) | Murali Devanaboyina High School Research |
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Alex Schmitz Medical Student |
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Colton Roessner Medical Student |
Currently accepting PhD and MD/PhD students for graduate studies and lab rotations.
Positions available:
- Postdoctoral Fellowship
- Residents and Clinical Fellows with research interests in the neurobiology of drug addiction
Contact gpendyala@unmc.edu for more information.
LAB TECHNIQUES
- Rodent animal models
- Cell and Molecular biology
- Biochemical Isolation of Synapses
- In vitro primary (neuronal, glial) and mixed cultures
- High throughput “Omics” approaches (Genomics, Transcriptomics, Proteomic)
LAB NEWS
- Grandchildren inherit harmful prescription opioid effects
- Gurudutt Pendyala, Ph.D., to receive Gilmore Award
- New investigator award: Gurudutt Pendyala, Ph.D.
- UNMC scientists receive grants to study cancer/smoking diseases
- Dr. Pendyala earns $470 thousand in recent research grants
- Pendyala Lab Student Volunteer Accepted into Harvard University
- Dr. Pendyala secures $2.3 million grant for addiction research
- APRDP, Tracy Tan, Completes Research Rotation
- Dr. Pendyala's Mentee, Rahul Guda, Making Waves
- Dr. Pendyala elected chair of ECITA Committee
CURRENT FUNDING
Child Health Research Institute/UNMC/Children's Hospital & Medical Center
Award Period: 07/01/2020 – 06/30/2021
Title: The conundrum of opioid use in the NICU: Providing comfort or aggravating development?
Role: Co-Investigator (PI: Sualy)
COBRE - Nebraska Center for Nanomedicine Pilot project
Award Period: 03/01/2019-12/31/2020
Title: “Characterizing Synaptic Architecture in Pre and Postnatal Oxycodone Exposed Offspring Using Clarity”
Role: Principal Investigator
Child Health Research Institute/UNMC/Children's Hospital & Medical Center
Award Period: 02/01/2020 - 01/31/2021
Title: Cord blood extracellular vesicle proteins as novel biomarkers to screen newborns exposed to intrauterine prescription opioids
Role: Principal Investigator
U2-18-FU910, National Strategic Research Institute/University of Nebraska
Award Period: 01/06/2020 - 01/05/2021
Title: Medical Countermeasure Drug Discovery & Development
Role: Co-Investigator (PI: Bayles/Berkowitz)
NIH/NIDA-R21DA049577
Award Period: 9/30/2019 to 8/31/2023
Title: "High-throughput integrated magneto electrochemical exosome (HIMEX) platform to identify neurodevelopmental markers associated with pre and postnatal oxycodone exposure"
Role: Principal Investigator
NIH/NEI R01EY030507
Award Period: 09/01/2019-05/31/2024
Title: “Influence of Ocular hypertension on neurons and synapses in the visual thalamus”
Role: Co-Investigator (PI: Van Hook)
NIH/NIDA-RO1DA046852
Award Period: 9/30/2018 to 6/30/2023
Title: "Extracellular vesicles, meth relapse, and sex differences"
Role: Principal Investigator
NIH/NIDA-DA046284
Award Period: 04/15/2019-03/31/2021
Title: "Therapeutic Efficacy of Ibudilast to Attenuate Inflammation at the Synapse"
Role: Principal Investigator
PREVIOUS FUNDING
NE DHHS LB506- 2020-42
Award Period: 07/01/2019-06/30/2020
Title: " Nicotine Addiction and Sex Differences: Role of Extracellular Vesicles"
Role: Principal Investigator
UNMC Office of Vice Chancellor of Research Core grant
Award Period: 01/01/2018-12/31/2018
“Oxycodone Exposure and Synaptic Development”
Role: Principal Investigator
Nebraska Center for Substance Abuse Research
Award Period: 11/1/17-10/31/18
Title: “Systems biology approach to identify novel blood biomarkers associated with opioid tapering”
Role: Principal Investigator
COBRE - Nebraska Center for Nanomedicine Pilot project
Award Period: 01/01/2018-06/30/2018
Title: “In vivo neuroimaging of brain metabolites after oxycodone exposure”
Role: Principal Investigator
Nebraska Research Initiative
Award Period: 07/1/15-06/30/17
Title: “Ageing and NeuroAIDS: Decoding the synapse”
Role: Co- Principal Investigator
IDEA Award, Department of Defense
Award Period: 09/30/13-09/29/16
Title: “Mechanisms of synaptic alterations in a neuroinflammation model of Autism”
Role: Co- Investigator
Nebraska Research Initiative
Award Period: 07/1/12-06/30/14
Title: “Strategies to prevent relapse in chronic methamphetamine users”
Role: Principal Investigator
NE DHHS –LB506 2014-04B
Award Period: 07/1/13-06/30/14
Title: “Sex Differences in Nicotine addiction: A systems approach to decipher the synapse”
Role: Principal Investigator
REPRESENTATIVE PUBLICATIONS
(Past two years)
Koul S, Schaal VL, Chand S, Pittenger ST, Nanoth Vellichirammal N, Kumar V, Guda C, Bevins RA, Yelamanchili SV, Pendyala G Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration. Cells. 2020 Aug 11;9(8):E1883. doi:10.3390/cells9081883.PMID: 32796722
Chand S, Jo, A Vellichirammal NN, Gowen A, Guda C, Schaal V, Odegaard K, Lee H, Pendyala G, Yelamanchili S. Comprehensive Characterization of Nanosized Extracellular Vesicles from Central and Peripheral Organs: Implications for Preclinical and Clinical Applications. ACS Applied Nano Materials. 2020 (In press)
Shahjin, F.; Guda, R.S.; Schaal, V.L.; Odegaard, K.; Clark, A.; Gowen, A.; Xiao, P.; Lisco, S.J.; Pendyala, G.; Yelamanchili, S.V. Brain-Derived Extracellular Vesicle microRNA Signatures Associated with In Utero and Postnatal Oxycodone Exposure. Cells. 2019 Dec 19;9(1):21. doi:10.3390/cells9010021.PMID: 31861723
Moore D, Meays BM, Madduri LSV, Shahjin F, Chand S, Niu M, Albahrani A, Guda C, Pendyala G, Fox HS, Yelamanchili SV. "Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder." Stem Cells Int. 2019 May 2;2019:8710180. doi: 10.1155/2019/8710180. eCollection 2019. PMID: 31191687
Pittenger SA, Schaal VL, Moore D, Guda RS, Koul S, Yelamanchili SV, Bevins RA and Pendyala G (2018) “MicroRNA cluster miR199a/214 are differentially expressed in female and male rats following nicotine self- administration” Scientific Reports 8:17464 doi: 10.1038/s41598-018-35747-z
Thangaraj A, Periyasamy P, Liao K, Bendi VS, Callen S, Pendyala G, Buch S. HIV-1 TAT-mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy. Autophagy. 2018 Jul 3. doi: 10.1080/15548627.2018.1476810. PMID: 29966509
Additional Publications in Pubmed. https://www.ncbi.nlm.nih.gov/sites/myncbi/1NwKZMtTqHnQJ/bibliography/47962309/public/?sort=date&direction=descending
COLLABORATORS
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Rick Bevins, PhD Dept. of Psychology, UNL |
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Siddappa Byrareddy, PhD Dept. of Pharmacology and Experimental Neuroscience, UNMC |
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Hakho Lee, PhD Dept. of Radiology, Harvard University |
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Mohanad Shukry, MD Dept. of Anesthesiology, UNMC |
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LAB PHOTOS
