Dr. Schiller's Laboratory

GENERAL LABORATORY INFORMATION
The Department of Anesthesiology's Human Physiology Laboratory research focuses on the quantification of sympathetic nervous system output and vascular control for clinically relevant applications, including intraprocedural feedback for renal denervation, hemorrhage and as a screening tool for the presence of dysautonomia. We are currently examining the dynamic relationship between arterial blood pressure and blood flow to quantify vascular control. Additionally, we are evaluating ways to improve medical monitoring technologies by incorporating novel data visualization and display techniques developed from the analysis of raw physiological data collected from Intensive Care Unit patients.

The laboratory, led by Alicia Schiller, PhD, consists of a 680 square-foot space with wet lab capabilities. It is connected to a private 250 square-foot space designed specifically for human subject experiments. Current laboratory equipment includes:

Future plans include the addition of a lower body negative pressure chamber. 

FUNDING

PUBLICATIONS

Comparisons of Traditional Metabolic Markers and Compensatory Reserve as Early Predictors of Tolerance to Central Hypovolemia in Humans.
Schiller AM, Howard JT, Lye KR, Magby CG, Convertino VA.
Shock. 2018 Jul;50(1):71-77. doi: 10.1097/SHK.0000000000001034.
PMID: 29049136

 

The physiology of blood loss and shock: New insights from a human laboratory model of hemorrhage.
Schiller AM, Howard JT, Convertino VA.
Exp Biol Med (Maywood). 2017 Apr;242(8):874-883. doi: 10.1177/1535370217694099. Epub 2017 Jan 1. Review.
PMID: 28346013

 

Eppur Si Muove: The dynamic nature of physiological control of renal blood flow by the renal sympathetic nerves.
Schiller AM, Pellegrino PR, Zucker IH.
Auton Neurosci. 2017 May;204:17-24. doi: 10.1016/j.autneu.2016.08.003. Epub 2016 Aug 3. Review.
PMID: 27514571

 

Renal nerves dynamically regulate renal blood flow in conscious, healthy rabbits.
Schiller AM, Pellegrino PR, Zucker IH.
Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15;310(2):R156-66. doi: 10.1152/ajpregu.00147.2015. Epub 2015 Nov 4.
PMID: 26538235

 

Functional Renal Denervation Decreases Renal Vascular Control Quantified by Pressure-Flow Monitoring in Swine.
Pellegrino PR, Schiller AM, Wang HJ, Chatzizisis Y, Zucker I.
Journal of the American College of Cardiology.;71(11 Supplement):A1179.

 

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