Ashley Mohr

Assistant Professor, Biochemistry and Molecular Biology

Ashley.pngPhone: 402-559-3170 (Lab)
Lab Location: BCC 6.12.408
Office Location: BCC 6.12.396
Fax: 402-559-6650

University of Nebraska Medical Center, Omaha, Nebraska 2013

Lab Member:
Yamnah Hafeji, Masters Student


Research Interest:
Our research is focused on signaling pathways in cholangiocarcinoma, a cancer of the bile ducts. Cholangiocarcinoma is often diagnosed at late stages which makes curative treatments hard to come by and prognosis poor. We study mechanisms of apoptosis resistance, metastasis, and microRNA expression and function. Specifically, we are looking at receptor tyrosine kinase signaling as a mediator of cell survival, proliferation and migration. We are evaluating fibroblast growth factor receptor 4 and its role in chemotherapy resistance, tumor promotion and metastasis. Our initial studies have shown that inhibiting this pathway sensitizes cholangiocarcinoma cells to cell-death by chemotherapy and reduces proliferation. Our goal is to elucidate the mechanism of this pathway and determine new potential therapeutics.

Tribute to patients:

We have had the opportunity to meet with several patients who are affected by cholangiocarcinoma and this has been influential in motivating our studies. We are always open to talking with people who have this diagnosis, or their caregivers.

Together, as scientists and members of the community, we can form a better understanding of this rare and devastating cancer, with an eye toward hope, treatment, and cure. We recognize your struggle and salute your efforts in dealing with cholangiocarcinoma.


My Publications