Molecular & Biochemical Etiology Program (MBEP)

MBEP Mission: To discover and validate mechanisms of cancer initiation and progression that may lead to novel biomarkers and therapeutic targets, with an emphasis on breast, prostate and ovarian cancers. The following programmatic goals provide a pathway to this end:

1) Discover alterations of molecular mechanisms that maintain intact genomes.
2) Discover alterations in intracellular signaling mechanisms and tumor cell-microenvironment interactions.
3) Validate cancer mechanisms, biomarkers, and targets using cell-based in vitro and animal models.

The MBEP is organized into 3 themes that closely align with the goals delineated above.

MBEP THEMES

Genome Instability and Cancer

Signaling Mechanisms in Cancer

Cellular Basis of Cancer

Discover alterations of molecular mechanisms that maintain intact genomes

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Discover alterations in intracellular signaling and tumor cell-microenvironment interactions

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Using in vitro and animal models, validate cancer mechanisms, biomarkers and targets

Program Leaders:

Hamid Band, M.D., Ph.D.  Hamid Band, M.D., Ph.D. 
Professor, Eppley Institute
Director of the Center for Breast Cancer Research
Associate Director of Translational Research

402-559-8572 
hband@unmc.edu 

Kay-Uwe Wagner, Ph.D.

Kay-Uwe Wagner, Ph.D. 
Professor, Eppley Institute

402-559-3288 
kuwagner@unmc.edu