Sundaralingam Premaraj, BDS, MS, PhD, FRCD(C)

Dr. Premaraj

Associate Professor and Graduate Program Director

Vice-Chair, Department of Growth & Development
Henry and Ann Cech Professor of Orthodontics
Bioregulation Group
University Dental Associates

Contact Information

Room 2436, UNMC College of Dentistry
4000 East Campus Loop South
Lincoln, NE 68583-0740
402-472-4970

Education

Teaching Responsibilities 
  • ORT 638 Clinical Orthodontics I: Course Director
  • ORT 676 Clinical Orthodontics II: Course Director
  • PG 849 Biophysical principles I: Course Director
  • PG 850 Biophysical principles II: Course Director
  • PG 844 Cephalometrics: Course Director
  • Postgraduate Principles of Mechanics/Orthodontic Technique: ;Course Director
  • Dentofacial Program: Instructor
  • Ortho-Perio Interdisciplinary Seminar: Instructor
  • Critical Review of Current Literature: Instructor
  • Clinical Orthodontic Seminars: Instructor
  • Dentofacial Clinical Conference: Instructor
  • Ortho-Endo Graduate Student Seminar: Instructor
Research Interests 
  • Cranial Suture Biology
  • Tgf-β3 Cell Signaling in Osteoblasts
  • Molecular Biology of Tooth Movement
Grants 
  • Effects of Flash-free Brackets on Plaque Retention, Development of White Spot Lesions, and Bracket Failures: a Comparative Clinical Study, 3M Unitek, September 2015, PI: Sundaralingam Premaraj
  • Neuropilin-2 Axis in Docetaxel Resistance and Prostate Cancer Bone Metastasis, DHHS/NIH/NCI (1R01CA182435-01A1), 02/01/2015 - 01/31/2020 Co-PI: Sundaralingam Premaraj ( PI: Kaustubh Datta)
  • Shift in Species Composition of Supra and Subgingival Gingival Microbiome as a Risk Factor In Dental Caries/Periodontal Disease: A Comparative Study with Braces/Invisalign Treatment. Align Technology, Inc., July 2013, Co-Investigator: Sundaralingam Premaraj, PI: Thyagaseely Premaraj
  • Role of PTHrp in Orthodontic Tooth Movement. American Association of Orthodontists Foundation, July 2012, PI: Sundaralingam Premaraj.
  • Shift in Species Composition of Supra and Subgingival Gingival Microbiome as a Risk Factor in Dental Caries/Periodontal Disease: A Comparative Study with Braces/Invisalign Treatment., Align Technology, July 2012, Co-Investigator: Sundaralingam Premaraj, PI: Thyagaseely Premaraj.
Selected Publications 
  • Premaraj S and Premaraj T, Orthodontic loading and SOST/Sclerostin Expression in Rat Alveolar Osteocytes, Sri Lanka Journal of Orthodontics, 2018; 1(1): 28-33
  • Premaraj SP, Luong B, Sung K, Premaraj TS. Cervical spine angles, craniocervical posture, neck length and oropharyngeal airway analyses of sleep apnea patients in both supine and upright positions: A retrospective three-dimensional imaging study. In: McNamara JA, Shelgikar AV, eds. Sleep Apnea: What Every Clinician (and Patient) Should Know. Craniofacial Growth Series, Center for Human Growth and Development, The University of Michigan, Ann Arbor, MI 2018;54:319-347.
  • Premaraj TS, Scott JR, Burns ME, Premaraj SP. CBCT evaluation of volumetric changes in the upper airway following repositioning the mandible to centric relation. In: McNamara JA, Shelgikar AV, eds. Sleep Apnea: What Every Clinician (and Patient) Should Know. Craniofacial Growth Series, Center for Human Growth and Development, The University of Michigan, Ann Arbor, MI 2018;54:381-399.
  • Premaraj T. S, Rohani N, Covey D, Premaraj S, In-Vitro Evaluation of Surface Properties of Pro Seal® and Opal® SealTM in Preventing White Spot Lesions, Orthodontics and Craniofacial Research, 2017, 20 Suppl 1:134-138.
  • Qari H, Narayana N, Kessler H, Premaraj S, Symmetrical Multiquadrant Isolated Dentin Dysplasia (SMIDD), a unique presentation mimicking Dentin Dysplasia Type 1b, Oral Surg Oral Med Oral Pathol Oral Radiol. 2017; 123(5): e164-e169.
  • Rachel C. K, Premaraj S, Smith B, Olson G, Williamson A, and Romanos G, Massive Open Online Courses in Dental Education: Two Viewpoints, Journal of Dental Education, 2016 ;80(2):121-7.
  • Hua Y, Gu L, Premaraj S, Zhang X, Influence of interphase on mechanical behavior of silica/epoxy resin nanocomposites, Materials 2015, 8, 3519-3531.
  • Premaraj T, Rohani N, Covey D, Premaraj S, Hua Y, Watanabe H, An in-vitro evaluation of mechanical and esthetic properties of orthodontic sealants, European Journal of Dentistry, 2014 8(4) 487- 492.
  • Premaraj T, Simet S, Beatty M, Premaraj S, Oral Epithelial Cell reaction following exposure to Invisalign® plastic Material, American Journal of Orthodontics and Dentofacial Orthopedics, 2014 145(1): 64-71
  • Premaraj S, Invited Editorial: What is really new in Orthodontics? Sri Lanka Dental Journal 2013, 43(3), 107-108.
  • Premaraj S, Souza I, Premaraj T, Focal Adhesion Kinase Mediates β-Catenin Signaling in Periodontal Ligament Cells, Biochemical and Biophysical Research Communications, 2013 439(4): 487-452
  • Premaraj S, Moursi A., Delivery of Transforming Growth Factor-Beta 3 Plasmid in a Collagen Gel Inhibits Cranial Suture Fusion in Rats, The Cleft Palate-Craniofacial Journal, 2013 50(3): e47-60
  • Premaraj S, I. Souza, T. Premaraj, Mechanical loading activates beta-catenin signaling in periodontal ligament cells, The Angle Orthodontist, 2011 81(4) 592-9
  • Premaraj S, Mundy B, Morgan D, Winnard PL, Mooney MP, Moursi AM: Sustained delivery of bioactive cytokine using a dense collagen gel vehicle, Archives of Oral Biology, 2006 51(4):325-33.
  • Premaraj S, B. Mundy, J. Parker-Barnes, P. L. Winnard and A. M. Moursi: Collagen Gel Delivery of Tgf-beta3 gene in Rat osteoblast and Calvarial culture, Orthodontics and Craniofacial Research, 2005 8(4):320-2.
  • Wada Akira, Hasebe Osamu, Sugiura Iwane, Itou Kouzi, Kubo Katsutoshi, Sundaralingam Premaraj, Maeda Akihiko, Kameyama Yoichiro: Effects of doxorubicin hydrochloride in the rat mandibular condyle Japanese Journal of Oral Science, 47 (5): 594-595, 1998.
Selected Abstracts 
  • P. Afousi, T. Premaraj and S. Premaraj, Effects of Flash-Free Bonding Technique on Plaque Retention and Development of White Spot Lesions: A Randomized Clinical Trial, European Journal of Orthodontics, 39 (5): e34, 2017
  • C. Schultz, S. Premaraj and T. Premaraj, Changes in Upper Airway Volume Following Surgical Removal of Adenoids, J Dent Res, 95(Spec Iss B): 1082, 2016
  • T. Premaraj, J. Scott, M. Burns and S. Premaraj, Volumetric Airway Changes with Mandibular Repositioning at CR by CBCT, J Dent Res, 95(Spec Iss B): 1080, 2016
  • R. Soyland, J. Ye and S. Premaraj, Bond Strength and Adhesive-cleanup of Brackets Bonded with Flash-free/Conventional adhesive, J Dent Res, 95(Spec Iss A): 1030, 2016
  • T. Premaraj, C. Anderson, S. Premaraj, and S. Fernando, Bacterial community structure in endodontic infections, J Dent Res., 93 (Spec Iss. B): 394, 2014
  • S. Premaraj and T. Premaraj, Orthodontic Loading and SOST/Sclerostin Expression in Rat Alveolar Osteocyte, J Dent Res., 93 (Spec Iss. B): 1665, 2014
  • A. Meyer, S. Premaraj, M. Beatty and T. Premaraj, Oral Epithelial Cell Response to Orthodontic Plastic - Preliminary Report, J Dent Res., 91 (Spec Iss B): 366, 2012
  • K. Russell, T. Premaraj, and S. Premaraj, Expression of Chemokines in Periodontal Tissues during Orthodontic Tooth Movement, J Dent Res., 91 (Spec Iss B): 641, 2012
  • S. Premaraj, F. Chau and T. Premaraj Tooth Extraction/Hypofunction-Induced Changes in Alveolar Osteocyte Expression of SOST/Sclerostin, J Dent Res., 91 (Spec Iss B): 1617, 2012
  • S. Premaraj, I. Souza, T. Premaraj, Molecular mechanisms of orthodontic tooth movement: emerging concepts, Eur J Orthod, e42, 2011
  • S. Premaraj, I. Souza, T. Premaraj, Nitric Oxide Mediates Mechanical loading-induced beta-catenin signaling in PDL cells, J Dent Res., 90 (Spec Iss A): 1527, 2011
  • C. Parks, J. Shin, T. Premaraj, S. Premaraj, FAK Regulates Activation of Beta-Catenin Signaling in Compressed PDL Cells, J Dent Res., 90 (Spec Iss A): 3651, 2011
  • L. Petersen, J. Shin, T. Premaraj, S. Premaraj, PGE2 mediates mechanical loading-induced up-regulation of Cx43 in PDL cells, J Dent Res., 90 (Spec Iss A): 3646, 2011
  • J. Stengle, L. Talluri, I. Souza, T. Premaraj, and S. Premaraj, Prostaglandin E2 Activates Beta-Catenin Signaling in Periodontal Ligament (PDL) Cells, J Dent Res., 89 (Spec Iss B): 3748, 2010.
  • S. Premaraj, I. Souza, M. Talluri, M. Guerrero, J. Barta, T. Premaraj: Mechanical strain activates beta-catenin signaling in periodontal ligament cells, J. Dent. Res 89 (Spec Iss A), 2010.
  • S. Jayappa, J. Thoendel, A. Moursi, S. Premaraj: Transforming growth factor-beta3 induced apoptosis of osteoblasts, J Dent Res 87 (Spec Iss B), 2008.
  • B. McIntyre, J. Thoendel, A. Moursi, S. Premaraj: Effects of Transforming growth factor-beta3 on proliferation and differentiation of MC3T3-E1 cells, J Dent Res 87 (Spec Iss B), 2008.
  • S. Premaraj, B. Mundy, M. Mooney and A. M. Moursi: Inhibition of Rat Cranial Suture Fusion with Plasmid Encoding Tgf-beta3, J Dent Res 85 (Spec Iss A):(1223), 2006.
  • A.M. Mercado, K. Lubitz, J. Halderman, S. Premaraj, M. Beck, P. Larsen, and K. Vig: Root Development and Bone grafting in Patients with Alveolar Clefts, J Dent Res 85 (Spec Iss A):(0124), 2006.
  • J. Halderman, K. Lubitz, S. Premaraj, F.M. Beck, A.M. Mercado, P. Larsen, and K.W.L. Vig: Canine Eruption and Secondary Alveolar Bone Grafting in UCLP Patients, Journal of Dental Research 84 (Spec Iss A):3690, 2005.
  • K. Lubitz, J. Halderman, S. Premaraj, F.M. Beck, A.M. Mercado, P. Larsen, and K.W.L. Vig: Canine Root Development and Alveolar Bone Grafting in UCLP Patients, Journal of Dental Research 84 (Spec Iss A) 2005.
  • S. Premaraj, J. Parker-Barnes, P.L. Winnard, and A.M. Moursi: Collagen gel delivery of TGF beta-3 gene in Calvarial osteoblast, Journal of Dental Research 83 (Spec Iss A):17, 2004.
  • S. Premaraj, F.M. Beck, P. Larsen, and K.W.L. Vig: Outcome of secondary alveolar bone grafting in cleft lip and palate patients, Journal of Dental Research 80(Spec Iss A):2949, 2002.
  • S. Premaraj, H. Tanaka, S. Konishi, K. Kubo, H. Maeda, S. Goto and Y. Kameyama: Effects of Cyclosporine-A on the alveolar bone in rats, Journal of Dental Research 77(IADR abstracts): 1999.
  • H. Tanaka, S. Premaraj, J. Muramatsu, Y. Tsujikoka, H. Maeda and Y. Kameyama: Periodontal tissues of the growing Vitamin C Deficient Rats, Journal of Dental Research 77(IADR abstracts):975, 1998.
Research Communications 
  • October 1998: Effects of 5-Fluorouracil on the mandibular condyle of the rats, Y. Suzumura, E. Sato, S. Premaraj, H. Maeda, and Y. Kameyama, 40th Annual Sessions of the Japanese Association of Oral Biology, Nagoya, Japan.
  • May 1998: (Table Clinic) Application of Biofeedback technique using Tongue Training Plate in the treatment of abnormal habits- Case reports, Y. Fuwa, S. Hayakawa, T. Kondo, S. Premaraj and S. Goto, 98th Annual Session of the American Association of Orthodontists, Dallas, Texas, USA.
  • May 1998: (Table Clinic) Application of Biofeedback technique using Tongue Training Plate (TTP) in the treatment of anterior tongue thrust, S. Goto, S. Hayakawa, T. Negoro, Y. Fuwa, T. Kondo, S. Premaraj, 98th Annual Session of the American Association of Orthodontists, Dallas, Texas, USA.
  • November 1999: Possible use of Internet for the teaching of histology to University of Peradeniya students, B.R.RN Mendis, R. Abayaratne, A.W. Ranasinghe, S. Premaraj. Annual Research Sessions, University of Peradeniya, Peradeniya, Sri Lanka.
  • February 2001: Quality evaluation of information on oral and dental conditions on the World Wide Web, S. Premaraj, B.R.RN Mendis. Annual scientific sessions of the Kandy Society of Medicine, Kandy, Sri Lanka.
  • May 2002: Evaluation of secondary alveolar bone grafting using a modified Bergland scale, S. Premaraj, F.M. Beck, P. Larsen, and K.W.L. Vig. Annual meeting of American Cleft palate and craniofacial association, Seattle, Washington, USA.
  • June 5-9, 2004: Delivery of TGF-beta 3 plasmid DNA via collagen gel in rat Calvarial osteoblast culture, M. Moursi, S. Premaraj, J. Parker-Barnes, P. L. Winnard, 31st European Symposium on Calcified tissues, Nice, France.
  • August 27-30, 2004: Collagen Gel Delivery of Tgf-beta 3 Gene in Rat Osteoblast and Calvarial Culture, S. Premaraj, B. Mundy, J. Parker-Barnes, P.L. Winnard, A.M. Moursi. Conference on Orthodontic Advances in Science and Technology (COAST), 2nd Biennial Conference, Pacific Grove, California, USA.
  • April 4-9, 2005: Non-Viral Delivery and Subsequent Expression of Plasmid-Encoded Tgf-Beta3 via Collagen Gel in Osteoblast and Calvarial Culture, S. Premaraj, B.L. Mundy, M.P. Mooney, A.M. Moursi. Presented at the 62nd Annual meeting of American Cleft palate and craniofacial association, Myrtle Beach, South Carolina, USA.
  • April 3-8, 2006: Delivery of Transforming Growth Factor-Beta 3 Plasmid in a Collagen Gel Vehicle Delays Fusion of the Rat Posterior Frontal Suture in Vivo, S. Premaraj, B. Mundy, M. Mooney, A.M. Moursi. Abstract presented at the 63rd Annual Meeting of the American Cleft Palate-Craniofacial Association, Vancouver, BC, Canada.
  • April 3-8, 2006: Canine Root Development and Outcome of Alveolar Bone Grafting In Patients with Unilateral Cleft Lip and Palate, Ana Mercado, Kathryn Lubitz, Josh Halderman, Sundaralingam Premaraj, Michael Beck, Peter Larsen, Katherine Vig. Abstract presented at the 63rd Annual Meeting of the American Cleft Palate-Craniofacial Association, Vancouver, BC, Canada.
  • April 23-28, 2007: Apoptosis regulation in TGF-beta3 gene therapy mediated cranial suture patency, Paper presented at the 64th Annual meeting of ACPA, Broomfield, CO.
  • May 16-20, 2008: Accuracy of Dolphin 3D cephalometric analysis using CBCT vs. Traditional radiography,” S. Swenson, J. Brand, S. Harn and S. Premaraj. Abstract presented at 108th Annual Session of American Association of Orthodontists (AAO), Denver, CO.
  • Oct 16-19, 2008: Effects of Transforming growth factor-beta3 on osteoblast apoptosis, proliferation and differentiation, S. Jayappa, B. McIntyre, J. Thoendel, A. Moursi, S. Premaraj, Abstract presented, 149th Annual meeting of ADA, San Antonio, TX.
  • May 1-4, 2010: Mechanical strain, PGE2 and Beta-Catenin signaling interactions in Periodontal Ligament Cells, T. Premaraj, L. Talluri, I. Souza, M. Stengle, S. Premaraj, Abstract presented at the Annual meeting of AAO, Washington, DC.
  • May 14-17, 2011: Role of Sclerostin in Tooth Extraction-Induced Alveolar Bone Resorption, F. Chau and S. Premaraj, Abstract presented at the Annual meeting of AAO, Chicago, IL
  • May 26-29, 2011: FAK Regulates Activation of Beta-Catenin Signaling in Compressed PDL Cells, C. Parks, J. Shin, T. Premaraj, S. Premaraj, Poster presented at the 64th Annual session of the American Academy of Pediatric dentistry, New York City, NY.
  • June 19-23, 2011: Molecular mechanisms of Tooth movement: Emerging concepts, S. Premaraj, I. Souza, T. Premaraj, Paper presented at the 87th Congress of the European Orthodontic Society, Istanbul, Turkey.
  • May 5-8, 2012: Oral Epithelial Cell Response to Orthodontic Plastic - Preliminary Report, C. Hopke, S. Premaraj, T. Premaraj, and Poster presented at the Annual meeting of AAO, Honolulu, HI.
  • June5-10, 2017: Effects of Flash-Free Bonding Technique on Plaque Retention and Development of White Spot Lesions: A Randomized Clinical Trial, Poster presented at the 93rd Congress of the European Orthodontic Society, Montreux, Switzerland.
  • May 4-8, 2018: Stadiem J, Premaraj T, Harrington J, Premaraj S, CPAP-MAD Combination therapy for CPAP intolerant patients with moderate to severe Obstructive Sleep Apnea, AAO Annual Session ( May 4-8, 2018), Washington, DC.
Honors and Awards 
  • 2014: Fellow, American Dental Education Association (ADEA) Leadership Institute
  • 2012: Fellow of the International College of Dentists (FICD)
  • 2010: AAOF Eugene E. West Memorial Fellowship.
  • 2010: AAO Full-time Faculty Teaching Fellowship
  • 2010: Hatton Award Finalist, Post-doctoral category, American Association of Dental Research
  • 2009: AAO Full-time Faculty Teaching Fellowship
  • 2009: Dr. William E. Ludwick Endowed Faculty Fellowship
  • 2008: AAO Full-time Faculty Teaching Fellowship
  • 2008: AAOF Subtelny Baker, Eastman Teaching Fellowship
  • 2008: D.H. Reinhardt Scholar
  • 2007: AAOF Robert M. Ricketts Sunflower Orthodontics Fellowship
  • 2006: Cleft Palate Foundation - James F. Mulick Orthodontic Scholarship
  • 2004: Graduate Student Award, Conferences on Orthodontic Advances in
    Science &Technology
  • 2004: Sarnat Award Finalist, International Association of Dental Research
  • 1997: Government of Sri Lanka Graduate Fellowship
Professional Affiliations 
  • American Association of Orthodontists (AAO)
  • American Cleft Palate and Craniofacial Association (ACPA)
  • International Association of Dental Research (IADR)
  • American Association of Dental Research (AADR)
  • American Dental Education Association (ADEA)
Service Activities 
  • 2018: Site visitor, Commission on Dental Accreditation (CODA)
  • 2018: President-Elect, IADR/AADR/Craniofacial Biology Group
  • 2017-Present: Member, Objective Review Committee, HRSA
  • 2017: Vice-President, IADR/AADR/Craniofacial Biology Group
  • 2017: Editor, Society of Educators, American Association of Orthodontists
  • 2016-Present: Member, Advanced Dental Admission Test (ADAT) Case development Committee - Orthodontics, Joint Commission on National Dental Examinations
  • 2015-Present: Member, Advanced Dental Admission Test (ADAT) Construction Committee - Orthodontics, Joint Commission on National Dental Examinations
  • 2015-Present: Member, NBDE Part 2 Test Construction Committee - Orthodontics, Joint Commission on National Dental Examinations
  • 2016-Present: Consultant, Division of Public health investigations, Department of Health and Human Services, State of Nebraska
  • 2012-2015: Director, IADR/AADR/Craniofacial Biology Group
  • 2014-2015: Member, Governance Stakeholders committee, American Association of Orthodontists
  • 2010-2011: President, Nebraska Society of Orthodontists
  • 2009-2010: Vice-President, Nebraska Society of Orthodontists
  • 2008-2009: Secretary-treasurer, Nebraska Society of Orthodontists
  • 2007-2014: Member, Education Committee, American Cleft Palate-Craniofacial Association
  • 2000–2001: Treasurer, Sri Lanka Orthodontic Society
  • 1992–1994: Secretary, Sri Lanka Dental Association, Kandy Branch