Michael Brattain, PhD Selected Publications

Sawhney R, Cookson M, Sharma B, Hauser J, Brattain M. Autocrine TGFa regulates cell adhesion by multiple signaling via phosphorylation sites of p706K in colon cancer cells. J. Biol. Chem. 279(45):47379-47390, 2004.

Huang W, Zhao S, Ammanamanchi, S, Brattain M, Venkatasubbaro K, Freeman, TSA induces TGFb type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1/NFY complex. Biol. Chem. 280(11):10047-54, 2005.

Zhou YF, Brattain MG Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis. Cancer Res. 65:5848-5856, 2005.

Hu YP, Venkatesarlu S, Sergina N, Howell G, St Clair P, Humphrey LE, Li W, Hauser J, Zborowska E, Willson JK, Brattain MG. Reorganization of ErbB family and cell survival signaling following knockdown of ErbB2 in colon cancer cells. J Biol Chem., 280(29 :27383-27392, 2005.

Zhou Y, Li S, Zborowska E, Hu PY, Wang J, Hauser J, Conway A, Vinci MA, Humphrey L, Willson JKV, Brattain MG. Blockade of EGFR and ErbB2 by a Novel Dual EGFR and ErbB2 TKI GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis. Cancer Res. 66:404-411, 2006.

Spengler M and Brattain M. Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription. J Biol. Chem.281:5567- 5574, 2006.

Sawhney RS, Cookson MM, Omar Y, Hauser J, Brattain MG. Integrin alpha 2-mediated ERK and calpain activation play a critical role in cell adhesion and motility signaling: identification of a novel signaling pathway. J Biol. Chem. 281: 8497-8510, 2006.

Rajput A, Koterba AP, Kreisberg JI, Foster JM, Willson JKV, Brattain, MG. A novel mechanism of resistance to epidermal growth factor antagonism In Vivo. Cancer Res., 67:665-673, 2007.

Wang J, Kuropatwinski K, Hauser J, Rossi MR, Zhou Y, Conway A, Kan JLC, Gibson NW, Willson JKV, Cowell JK, Brattain MG. Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis. Mol Cancer Ther., 6:1143 1150, 2007.

Guo XL, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman R, Brattain MG, Wang J. Mutant PIK3CA bearing cells display increased metastasis in an orthotopic model. Cancer Res. 67: 5851-5858, 2007.