Professor, Eppley Institute
Courtesy Professor, Dept of Environmental, Agricultural & Occupational Health
DSc - University of Milan, Milan, Italy, 1962
Recent Awards: UNMC Distinguished Scientist, 2007
Molecular mechanisms of tumor initiation by polycyclic aromatic hydrocarbons (PAH) and estrogens. Origin of human cancer at the molecular level. Prevention of cancer.
This research includes: (a) in vitro and in vivo binding studies of estrogens to DNA, determination of the structure and quantitation of the adducts; (b) correlation of ras-oncogene mutations and formation of depurinating estrogen-DNA adducts; (c) mechanism of tumor initiation by catechol quinones of natural and synthetic estrogens; (d) analysis of biomarkers for the etiology and early detection of breast, prostate and other human cancers; (e) chemoprevention of human cancers by resveratrol, N-acetylcysteine and other compounds that reduce the formation of depurinating estrogen-DNA adducts. .
Cavalieri, E. and Rogan, E. The molecular etiology and prevention of estrogen-initiated cancers. Mol. Aspects Med., 36:1-55, 2014.