Suyong Choi, PhD
Assistant Professor, Eppley Institute
Telephone: 402-559-1953 (Office)
Email: Suyong Choi
BS - Seoul National University, Seoul, South Korea
MS - Seoul National University, Seoul, South Korea
PhD - University of Wisconsin-Madison, Department of Pharmacology, Madison, WI
PostDoc - University of Wisconsin School of Medicine and Public Health, Madison, WI
Phosphoinositide signaling pathways in cancer and immunology
Summary of Research:
My lab seeks to discover novel signaling mechanisms through which lipid second messengers phosphoinositides regulate tumor survival, proliferation, metastasis, and chemoresistance in cancer and to develop new therapeutics that target these mechanisms. Cancer cells hijack and elaborate several signaling pathways critical for their survival and dissemination. Cancer promoting roles of the phosphoinositide signaling pathway (especially the PI3K-Akt pathway) is well-established, however, its roles in nuclear functions are largely unknown. We would like to complement biochemical and cell biological techniques and animal models in cancer biology to be a pioneer in the nuclear phosphoinositide signaling pathway in cancer. We have an expertise to identify and characterize phosphoinositide binding proteins. These include IQGAP1 (EMBO J, 2013; Nature Cell Biology, 2016), p53 (Nature Cell Biology, 2019; Nature Cell Biology, under revision) and MAP4 (Nature Cell Biology, 2021). Additionally, via proteomic screen and functional validation we have identified several key nuclear proteins including transcription regulators, epigenetic regulators, and DNA repair complexes are regulated by nuclear phosphoinositides. Roles of phosphoinositide binding with these newly identified nuclear proteins in cancer will be investigated with immediate focuses on the YAP/TAZ pathway regulation by the nuclear phosphoinositide signaling. We highly value active hands-on training and mentoring to promote students develop constructive critical thinking skills to lead their projects.
Publications/or Selected Publications
- Choi, S., Lee, S.A., Kwak, T.K., Kim, H.J., Lee, M.J., Ye, S.K., Kim, S.H., Kim, S., and Lee, J.W. 2009. Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood 113, 1845-1855.
- Choi, S., Thapa, N., Hedman, A.C., Li, Z., Sacks, D.B., and Anderson, R.A. (2013). IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J 32, 2617-2630.
- Choi, S., Thapa, N., Tan, X., Hedman, A.C., and Anderson, R.A. (2015) PIP kinases define PI4,5P2 signaling specificity by association with effectors. Biochim Biophys Acta 1851, 711-723.
- Choi, S., Hedman, A.C., Thapa, N., Sacks, D.B., Anderson, R.A. (2016) Agonist-stimulated PI3,4,5P3 generation by scaffolded phosphoinositide kinases. Nature Cell Biology 12, 1324-1335.
- Choi, S., Houdek, X., Anderson, R.A. (2018) Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases. Adv Biol Regulation 68, 31-38.
- Choi, S., Chen, M., Cryns, V., Anderson, R.A. (2019) A nuclear phosphoinositide kinase complex regulates p53. Nature Cell Biology 21, 462-475