Kenneth H. Cowan, MD, PhD Selected Publications

Dixon, K.H., Lanpher, B.C., Chiu, J., Kelley, K., and Cowan, K.H.: A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport-deficient cells. J. Biol. Chem. 269(1):17-20,1994.

Morrow, C., Nakagawa, M., Goldsmith, M.E., Madden, M.J., and Cowan, K.H.: Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells. J. Biol. Chem. 269(14):10739-10746,1994.

Goldsmith, M.E., Gudas, J.M., Schneider, E., and Cowan, K.H.: Wild type p53 stimulates expression from the human multidrug resistance promoter in a p53-negative cell line. J. Biol. Chem. 270(4):1894-1898,1995.

Dunbar, C., Cottler-Fox, M., O'Shaughnessy, J.A., Doren, S., Carter, C., Berenson, R., Brown, S., Moen, R., Greenblatt, J., Stewart, F.M., Leitman, S., Wilson, W., Cowan, K.H., Young, N.S., and Neinhuis, A.R.: Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contributed to long-term engraftment after autologous transplantation. Blood 85:3048-3057,1995.

Gudas, J., Nguyen, H., Li, T., Hill, D., and Cowan, K.H.: Effects of cell cycle, wild type p53 and DNA damage on p21CIPI/WafI expression in human breast epithelial cells. Oncogene 11:253-261,1995.

Moscow, J.A., He, R., Gong, M., Sgagias, M., Dixon, K.H., Anzick, S., Meltzer, P.S., and Cowan, K.H.: Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient methotrexate-resistant human breast cancer cells. Cancer Res. 55(17):3790-3794,1995.

Gudas, J.M., Nguyen, H., Li, T., and Cowan, K.H.: Hormone dependent regulation of BRCA1 in human breast cancer cells. Cancer Res. 55:4561-4565,1995.

O'Shaughnessy, J.A., Tolcher, A., Riseberg, D., Venzon, D., Zujewski, J., Noone, M., Gossard, M., Danforth, D., Jacobson, J., Chang, V., Goldspiel, B., Keegan, P., Giusti, R., and Cowan, K.H.: Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer. Blood 87(6):2205-2211,1996.

Emmons, R.V.B., Doren, S., Zujewski, J., Cottler-Fox, M., Carter, C.S., Hines, K., O=Shaughnessy, J.A., Leitman, S.F., Cowan, K., and Dunbar, C.E.: Retroviral gene transduction of adult peripheral blood or marrow decreased CD34+ cells for 6 hours without growth factors or an autologous stroma does not improve making efficiency assessed?in vivo. Blood,89:4040-4046, 1997.

Craig, C., Wersto, R., Kim, M., Ohri, E., Li, Z., Katayose, D., Lee, S-J., Trepel, J., Cowan, K., and Seth, P.: A recombinant adenovirus expressing p27Kip1?induces cell cycle arrest and loss of cyclin-cdk activity in human breast cancer cells. Oncogene, 14:2283-2290, 1997.

Seth, P., Li, Z., Kim, M./, Craig, C., Wersto, R., Shanmugan, M., Ohri, E., Rakkar, A., Kodali, P., Mudaahsar, B.S., and Cowan, K.H.: Adenovirus expressing wild type P53 induces apoptosis in drug resistant human breast cancer cells: a potential in vivo and ex vivo gene therapy approach for Drug Resistant Tumors. Gene Therapy 4: 383-390, 1997.

Seth, P., Katyose, D., Li, Z., Kim, M., Wersto, R., Craig, C., Shannmugan, S., Ohri, E., Mudahsar, B., Rakkar, A.N., Kodali, P., and Cowan, K. A recombinant adenovirus expressing wild type P53 induces apoptosis in drug-resistant human breast cancer cell: a gene therapy approach for drug resistant cancers. Cancer Gene Therapy 4: 383-390,1997.

Katyose, Y., Kim, M.,Rakkar, A.N.S., Li, Z., Cowan, K.H. and Seth, P. Promoting Apoptosis: a Novel Novel Activity Associated with Cyclin Dependent Kinase Inhibitor p27Kip1. Caner Res.,15: 5441-5445, 1997.

Craig, C., Kim, M., Ohri, E., Wersto, R., Katyose, D., Li, Z., Choi, Y.H., Mudahasar, B., Srivastava, S., Seth, P., and Cowan, K.H.: Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in Human Cancer Cells. Oncogene, 16:265-272,1998.

Li, Z., Rakkar, A., Katyose, Y., Kim, M., Naga, S., Srivasta, S., Moul, J., McLeod, D., Cowan, K.H., and Seth, P. Efficacy of multiple administrations of a recombinant adenovirus expressing wild type p53 in an immune-competent mouse tumor model. Gene Therapy, 5:605-613,1998.

Paul, D. and Cowan, K.H. Drug Resistance in Breast Cancer, in Breast Cancer: Molecular Genetics, and Therapeutics, A. M. Bowcock, ed., Human Press Inc., Totowa, NJ, 1998, 481-517.

Rakkar, A., Li., Z., Katayose,Y., Kim, M., Cowan, K.H., and Seth. P. Adenoviral expression of the cyclin-dependent kinase inhibitor p27kip1: a strategy for breast cancer gene therapy. J. Natl Cancer Institute,?90: 1836-1838,1998.

Rakkar, A.N.S., Katyose, Y., Kim, M., Craig, C., Choi, Y.H., Lee, S.H.,. Ohri, E., Li, Z., Cowan, K.H., and Seth, -PA novel adenoviral vector expressing human Fas/CD95/APO-1 enhances p53 mediated apoptosis. Cell Growth and Differentiation 6: 326-33, 1999.

K.H. Cowan, J. A. Moscow, H. Huang, J. Zujewski, J. O'Shaughnessy, B. Sorrentino, C. Carter, E. Schneider, G. Cusack, M. Noone, C. Dunbar, S. Steinberg, W. Wilson, B. Goldspiel, E.J. Read, S. Leitman, K. McDonagh, C. Chow, A. Abati, Y. Chiang, S. Weir, M. Gottesman, I. Pastan, and A. Nienhuis. Paclitaxel Chemotherapy Following Autologous Stem Cell Transplantation and Engraftment of Hematopoietic Cells Transduced With A Retrovirus Containing The Multidrug Resistance cDNA (MDR1) In Metastatic Breast Cancer Patients, Clin Cancer Res., 5 1619-1628,1999,

Moscow, J.A, Huang, H., Carter, C., Hines, K., Zujewski, J., Cusack, G., Chow,C. Venzon, D., Sorrentino, B., Chiang, Y., Goldspiel,B., Leitman S., Read, E.J. Andrea Abati , A., Gottesman, M.M., Pastan, I., Sellers, S., Dunbar, C. and Cowan, K.H. Engraftment of "MDR1" and NeoR Gene-Transduced Hematopoietic Cells Following Breast Cancer Chemotherapy, Blood, 94: 52-61, 1999.

M. Gong, K H. Cowan, J. Gudas and J. A. Moscow. Isolation and characterization of the human reduced folate carrier gene (RFC1) promoter. Gene, 233: 21-31,1999.

Smith, J. S., Keller, J. R. , Lohrey, N. C., MacCauslin, C.S. , Ortiz, M., Cowan, K., Spence, S.E. Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens. Proc. Natl. Acad., Sci., USA, 96: 8855-8860,.