• PI - Michael A. Hollingsworth, PhD

    PI - Michael A. Hollingsworth, PhD


The focus of the SPORE (Specialized Program of Research Excellence) in Pancreatic Cancer was on translational studies that addressed basic and clinical issues of importance to improve the outcomes of patients with pancreatic cancer.

The SPORE program was focused on 4 projects with high potential translational impact, and there were 3 highly interactive cores that continue to acquire, store, and make available a unique set of tissue samples, data (clinical, molecular, genetic, biological, pathological), reagents and resources.

This program of research presents a series of novel translational studies that were designed to provide new therapeutic interventions for patients with all stages of pancreatic cancer.

  • Two of the projects (1 and 4) attempted to target different aspects of tumor interactions with the microenvironment (nerves and stroma respectively).
  • Projects 2, 3 and 4 were directed towards killing tumor cells directly by distinct mechanisms (radiation, resistance to apoptosis, and chemotherapy respectively).
  • The cores contain highly novel components.
  • The tissue core (Core B) included a comprehensive rapid autopsy/organ harvest protocol unlike any other in the world, which utilized a team of 18 trained individuals to undertake complete organ harvest and processing that could be completed within two hours of death.