Publications

Teotia P, Niu M, Ahmad I. Mapping developmental trajectories and subtype diversity of normal and glaucomatous human retinal ganglion cells by single-cell transcriptome analysis. Stem Cells. 2020 Jun 18. doi: 10.1002/stem.3238. Online ahead of print.

Ahmad I, Teotia P, Erickson H, Xia X. Recapitulating developmental mechanisms for retinal regeneration. Prog Retin Eye Res. 2020 May;76:100824. doi:10.1016/j.preteyeres.2019.100824. Epub 2019 Dec 14. 

Teotia P, Hook MJV, Fischer D, Ahmad I. Human retinal ganglion cell axon regeneration by recapitulating developmental mechanism: effects of the recruitment of the mTOR pathway. 2019. Development (dev178012).

Teotia P, Hook MJV, Wichman CS, Allingham RR, Hauser MA, Ahmad I. Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities. Stem Cells. 2017 Nov; 35(11):2239-2252. 

Teotia P, Chopra DA, Dravid SM, Van Hook MJ, Qiu F, Morrison J, Rizzino A, Ahmad I. Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism. Stem Cells. 2017 Mar; 35(3):572-585.

Teotia P, Van Hook MJ, Ahmad I. A Co-culture Model for Determining the Target Specificity of the de novo Generated Retinal Ganglion Cells. Bio Protoc. 2017 Apr 5; 7(7). pii: e2212.

Xia X, Ahmad I. Unlocking the Neurogenic Potential of Mammalian Müller Glia. Int. J. Stem Cells. 2016; 9(2):169-175.

Xia X, Ahmad I. let-7 microRNA regulates neurogliogenesis in mammalian retina through Hmga2. Dev. Biol. 2016; 410(1):70-85

Del Debbio CB, Mir Q, Parameswaran S, Mathews S, Xia X, Zheng L, Neville AJ, Ahmad I. Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1. PloS ONE 2016; 11(3): e0152025

Ahmad I, Zhao X, Parameswaran S, Destache CJ, Rodriguez-Sierra J, Thoreson WB, Ahmad H, Sorrentino J, Balasubramanian S. Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons. Int. J. Stem Cells. 2015; 8:106-114.

Parameswaran S, Dravid MS, Tiotia P, Krishnamoorthy R, Toris CB, Morrison J, Ahmad I. Continuous non-cell Autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy. Stem Cells. 2015; 33:1743-1758.

Parameswaran S, Xia X, Hegde G, Ahmad I. Hmag2 regulates self-renewal of retinal progenitors. Development 2014; 141:4087-4097.

Del Debbio CB, Peng X, Xiong H, Ahmad I. Adult ciliary epithelial stem cells generate functional neurons and differentiate into both early and late retinal neurons under non-cell autonomous influences. BMC Neuroscience 2013; 14:130.

Parameswaran S, Balasubramanian S, Babai N, DelDebio C, Harms D, Channabasaviah G, Rao M, Sharp JG, Ahmad I. Nucleic acid and Non-nucleic acid-based reprogramming of adult limbal progenitors to pluripotency. PLoSONE 2012; 7:e46734.

Parameswaran S, Balasubramanian S, Rao M, Ahmad I. Non-cell autonomous reprogramming: a nucleic acid free approach to induction of pluripotency. Stem Cells 2011; 29:1013-1020.

Ahmad I, Parameswaran S, Del Debbio CB, Balasubramanian S, Katz AR, Toris C, Farris RN. Regulation of ocular angiogenesis by Notch signaling in rodents: implications in neovascular age-related macular degeneration. Invest. Ophthalmol. Vis. Res. 2011; 52:2868-2878.

Ahmad I, Del Debbio CB, Das A, Parameswaran S.  Muller glia: a promising target for therapeutic regeneration. Invest. Ophthalmol. Vis. Sci. 2011; 42:5758-5764.

Del Debbio CB, Balasubramanian S, Chaudhuri A, Qui F, Ahmad I. Notch and Wnt signaling-mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina. PLoS ONE 2010; 8:e12425.

Parameswaran S, Balasubramanian S, Babai N, Qiu F, Eudy J, Thoreson W, Ahmad I. Induced Pluripotent Stem Cells (iPSCs) generate both retinal ganglion cells and photoreceptors: therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration. Stem Cells 2010; 28:695-703.

Balasubramanian S, Babai N, Chaudhuri A, Bhattacharya S, Parameswaran S, Qiu F, Dave B, Thoreson W, Sharp J, Rao M, Ahmad I. Non cell-autonomous reprogramming of adult ocular progenitors: generation of pluripotent stem cells without exogenous transcription factors. Stem Cells 2009; 27:3053-3062.

Bhattacharya B, Das AV, Mallya K, Ahmad I. CNTF mediated signaling regulates neuronal versus glial differentiation of retinal stem cells/progenitors by concentration-dependent recruitment of MAPK and JAK-STAT pathways in conjunction with Notch signaling. Stem Cells 2008; 26:2611-2624.

Das AV, Bhattacharya S, Mallya K, Hegde G, Ahmad I. The canonical Wnt pathway regulates retinal stem cells/progenitors in concert with Notch signaling. Dev. Neurosci. 2008; 30:389-409.

Zhao X, Das AV, Bhattacharya S, Thoreson WB, Sierra, J.R., Mallya, K.B. and Ahmad, I. Derivation of neurons with functional properties from adult limbal epithelium: implications in autologous cell therapy for photoreceptor degeneration. Stem Cells 2008; 26:939-949.

Das AV, James J, Bhtattacharya S, Mallya KB, Ahmad I. SWI/SNF chromatin remodeling ATPase, Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. J. Biol. Chem. 2007; 282:35187-35201.

Hegde G, James J, Das A, Zhao X, Bhattacharya S, Ahmad I. Characterization of early retinal progenitor microenvironment: presence of activities selective for the differentiation of retinal ganglion cells and maintenance of progenitors. Exp. Eye. Res. 2006; 84:577-590.

Das A, Mallya BA, Zhao X, Ahmad F, Bhattacharya S, Thoreson WB, Hegde G, Ahmad I. Neural stem cell properties of Muller glia in the mammalian retina: Regulation by Notch and Wnt signaling. Dev. Biol. 2006; 299:283-302.

James J, Das AV, Bhattacharya S, Chacko DM, Zhao X, Ahmad I. In vitro generation of early born neurons from late retinal progenitors. J. Neurosci. 2003; 23:8193-8203.