Department of Genetics, Cell Biology and Anatomy
PhD, Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 2021
BS, Biology, Doane College, 2015
COM Phase 1 Blocks, Medical students
Structure and Development of the Human Body, Allied Health and Graduate students
Neuroanatomy, Graduate students
High School Alliance Gross Anatomy Course
American Association for Anatomy
Human Gross Anatomy, Histology, and Neurosciences to Medical, Allied Health, Graduate, and High School Alliance students.
Dr. Perry’s research focuses on the molecular mechanisms of DNA-protein crosslink repair. DNA-protein crosslinks are steric blockades to DNA replication and transcription that, if left unrepaired, lead to genome instability and oncogenic mutations. SPRTN protease is a key repair enzyme for DNA-protein crosslink degradation during DNA replication. We have investigated the regulation of SPRTN protease via post-translational modification and are studying how disruption of SPRTN regulation and other DNA-protein crosslink repair factors may be targeted in cancers that would otherwise acquire chemoresistance to standard DNA-protein crosslink-inducing therapies.
- Perry, M., Biegert, M., Kollala, S. S., Mallard, H., Su, G., Kodavati, M., Kreiling, N., Holbrook, A., and Ghosal, G. (2021) USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease. J Biol Chem 296, 100396.
- Perry M., Ghosal G. (2021) Isolation and immunodetection of enzymatic DNA-protein crosslinks by RADAR assay. Methods Mol Biol. In press.