Megan Perry, PhD

Assistant Professor


Department of Genetics, Cell Biology and Anatomy
986395 Nebraska Medical Center
Omaha, NE 68198-6395


PhD, Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 2021
BS, Biology, Doane College, 2015

Academic Appointments:
COM Phase 1 Blocks, Medical students 
Structure and Development of the Human Body, Allied Health and Graduate students 
Neuroanatomy, Graduate students
High School Alliance Gross Anatomy Course 

Professional Organizations:
American Association for Anatomy

Human Gross Anatomy, Histology, and Neurosciences to Medical, Allied Health, Graduate, and High School Alliance students.

Dr. Perry’s research focuses on the molecular mechanisms of DNA-protein crosslink repair. DNA-protein crosslinks are steric blockades to DNA replication and transcription that, if left unrepaired, lead to genome instability and oncogenic mutations. SPRTN protease is a key repair enzyme for DNA-protein crosslink degradation during DNA replication. We have investigated the regulation of SPRTN protease via post-translational modification and are studying how disruption of SPRTN regulation and other DNA-protein crosslink repair factors may be targeted in cancers that would otherwise acquire chemoresistance to standard DNA-protein crosslink-inducing therapies. 

  1. Perry, M., Biegert, M., Kollala, S. S., Mallard, H., Su, G., Kodavati, M., Kreiling, N., Holbrook, A., and Ghosal, G. (2021) USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease. J Biol Chem 296, 100396.
  2. Perry M., Ghosal G. (2021) Isolation and immunodetection of enzymatic DNA-protein crosslinks by RADAR assay. Methods Mol Biol. In press.