Karen A. Gould, Ph.D.

ASSOCIATE PROFESSOR

Karen A. Gould, Ph.D.

University of Wisconsin-Madison
1996

Phone: 402-559-2456
Fax: 402-559-7328
Email

UNMC responsibilities:

  • Vice Chair for Graduate Education, Genetics, Cell Biology & Anatomy
  • Co-Director, UNMC Interdisciplinary Graduate Program
  • Program Director, Masters in Medical Anatomy
  • Member, UNMC College of Medicine Admissions Committee
  • Instructor in graduate, medical and dental school courses in genetics, cell biology and histology

Teaching: Dr. Gould contributes to graduate education by training graduate students in her lab, coordinating and teaching in multiple graduate courses for graduate and professional students, and overseeing various graduate education programs.

Research Keywords: molecular genetics; estrogen action; immune function and autoimmunity; tumorigenesis

Research Areas: 

1. Estrogen receptor alpha regulation of lupus.

Lupus is a devastating autoimmune disease that is associated with considerable morbidity and mortality. Approximately 90% of patients with lupus are women. This dramatic sex bias is due to endogenous estrogens. Using a mouse model of lupus, we have shown that estrogens promote lupus via estrogen receptor alpha (ER-alpha), which acts in a B cell intrinsic manner to enhance B cell activation and loss of tolerance.  However, a concrete understanding of how ER-alpha signaling modulates B cell activation and loss of tolerance on a molecular level is unclear.  Our current studies use genetics as well as molecular and cellular biological approaches to understand how ER-alpha impacts B cell biology and the  development of lupus.

2. Identification the Mom5 Modifier of Intestinal Tumorigenesis.

Colon cancer is the third leading cause of cancer related deaths in men and women.  Genetic factors contribute to an individual risk of developing colon cancer, but most of the predisposing alleles are not known.  We have mapped a locus called Modifier of Min 5 (Mom5) that impacts tumor development in a mouse model of colon cancer. We have localized Mom5 to a very small region of the genome.  Current studies involve both genetic mapping and bioinformatics to identify the causative allelic variant underlying the Mom5 locus

Publications listed in PubMed

Selected Recent Publications:

  1. Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes.  Otterpohl KL, Gould KA.  Mamm Genome. 26(5-6):235-47, 2015
  2. Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice. Yoachim SD, Nuxoll JS, Bynoté KK, Gould KA. Clin Immunol. 158(2):153-66, 2015.
  3. A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis Yuan F, Tabor DE, Nelson RK, Yuan H, Zhang Y, Nuxoll J, Bynoté KK, Lele SM, Wang D, Gould KA.  PLoS One. 8(11) 2013
  4. Oikarinen SI, Cleveland AG, Cork K, Bynoté KK, Cleveland AG, Rafter JJ, Gustafsson J-Å, Mutanen M, and Gould KA.  Genetic Mapping of Mom5, a novel modifier of ApcMin-induced intestinal tumorigenesis. Carcinogenesis 30(9):1591-96, 2009.
  5. Bynoté, K.K., Hackenberg, J.M., Korach, K.S., Lubahn, D.B. Lane, P.H. and Gould, K.A. Estrogen Receptor Alpha Deficiency Attenuates Autoimmune Disease in (NZB x NZW)F1 Mice. Genes and Immunity, 9(2):137-52, 2008. *One of three "Featured Articles" in this issue.