Trey M. Farmer
Trey Farmer

Trey M. Farmer

PhD in Biochemistry & Molecular Biology

NCI Ruth L. Kirschstein National Research Service Award for Individual Predoctoral Fellows (2018-2020)

The NIH National Cancer Institute (NCI) Ruth L. Kirschstein National Research Service Award (NRSA) for Individual Predoctoral Fellows (F31) supports promising doctoral candidates who will perform dissertation research and training for a PhD degree in a scientific health-related field relevant to the mission of the NCI during the tenure of the award. Trey Farmer was awarded a 2-year F31 award for his project, entitled “A novel role for membrane trafficking in mitochondrial homeostasis and apoptosis.” He is studying the upstream regulation of mitochondrial fission and function in apoptosis by endocytic regulatory proteins, which can both be directly related to cancer progression. He aims to elucidate the mechanism through which EHD1 and Rabankyrin-5 regulate mitochondrial fission, and to explore a novel role for endocytic proteins in the trafficking of BCL-2 family members and the regulation of apoptosis. These efforts will employ CRISPR/Cas9 gene-edited cells, advanced imaging techniques, GST pull-downs, co-immunoprecipitation and other tools in an attempt to reveal new avenues for translational and clinical studies that may yield novel therapeutics for cancer patients. Trey completed his dissertation research under the mentorship of Dr. Steven Caplan, receiving the PhD degree in May 2020.