{"id":10092,"date":"2025-08-20T15:47:24","date_gmt":"2025-08-20T20:47:24","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=10092"},"modified":"2025-08-20T15:47:27","modified_gmt":"2025-08-20T20:47:27","slug":"promising-bird-flu-vaccine-advances-as-organoids-reveal-how-h5n1-scars-airways","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2025\/08\/20\/promising-bird-flu-vaccine-advances-as-organoids-reveal-how-h5n1-scars-airways\/","title":{"rendered":"Promising bird flu vaccine advances as organoids reveal how H5N1 scars airways"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2025-08-bird-flu-vaccine-advances-organoids.html\">Medical Express<\/a> Researchers at Texas Biomedical Research Institute have developed a new, proof-of-concept vaccine to protect people from the bird flu strain currently circulating in the United States. The team, led by Professor Luis Martinez-Sobrido, Ph.D. and Staff Scientist Ahmed M. Elsayed, Ph.D., recently\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41541-025-01207-9\" target=\"_blank\" aria-label=\"published, opens in a new window\" rel=\"noreferrer noopener\">published<\/a>\u00a0initial results in\u00a0<em>npj Vaccines.<\/em> The live attenuated vaccine contains a weakened (attenuated) version of the avian influenza virus that has sickened poultry and&nbsp;<a href=\"https:\/\/medicalxpress.com\/tags\/dairy+cows\/\">dairy cows<\/a>&nbsp;throughout the U.S. since March 2024. The vaccine candidate showed high efficacy in cells and animal models. A single dose was enough to protect mice from highly pathogenic H5N1, which would otherwise be lethal.<\/p>\n\n\n\n<p>The team is now working to develop versions of the vaccine that would address other bird flu strains circulating in hot spots around the world. Highly&nbsp;<a href=\"https:\/\/medicalxpress.com\/tags\/pathogenic+avian+influenza\/\">pathogenic avian influenza<\/a>&nbsp;is naturally carried by&nbsp;<a href=\"https:\/\/medicalxpress.com\/tags\/migratory+birds\/\">migratory birds<\/a>&nbsp;and waterfowl, but is deadly in domesticated chickens and turkeys.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Medical Express Researchers at Texas Biomedical Research Institute have developed a new, proof-of-concept vaccine to protect people from the bird flu strain currently circulating in the United States. The team, led by Professor Luis Martinez-Sobrido, Ph.D. and Staff Scientist Ahmed M. Elsayed, Ph.D., recently\u00a0published\u00a0initial results in\u00a0npj Vaccines. The live attenuated vaccine contains a weakened (attenuated) [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[37],"tags":[],"class_list":["post-10092","post","type-post","status-publish","format-standard","hentry","category-avian-influenza"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/10092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=10092"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/10092\/revisions"}],"predecessor-version":[{"id":10093,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/10092\/revisions\/10093"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=10092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=10092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=10092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}