{"id":1134,"date":"2022-10-28T09:20:06","date_gmt":"2022-10-28T14:20:06","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=1134"},"modified":"2022-12-13T11:21:42","modified_gmt":"2022-12-13T17:21:42","slug":"recurrence-of-symptoms-following-a-2-day-symptom-free-period-in-patients-with-covid-19","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2022\/10\/28\/recurrence-of-symptoms-following-a-2-day-symptom-free-period-in-patients-with-covid-19\/","title":{"rendered":"Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>(<a rel=\"noreferrer noopener\" href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2797789\" target=\"_blank\">JAMA<\/a>) Recurrence of symptoms after finishing treatment for COVID-19 with nirmatrelvir-ritonavir (Paxlovid) has become increasingly recognized.<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2797789#zld220246r1\">1<\/a>&#8211;<a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2797789#zld220246r1\">3<\/a><\/sup>\u00a0The biological underpinning of this phenomenon is unclear, and its etiology may be multifactorial, including rapid clearance of nirmatrelvir coupled with delayed immune responses or possible development of drug resistance.<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2797789#zld220246r1\">1<\/a>&#8211;<a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2797789#zld220246r1\">3<\/a><\/sup>\u00a0The contribution of treatment to symptom rebound needs to be differentiated from symptom rebound that might occur during the natural history of COVID-19. In this cohort study, we sought to determine how often COVID-19 symptoms recurred when the disease was untreated.<\/p>\n<!-- <a rel=\"nofollow\" href=\"\/secure-location.php\" title=\"yJW O jrq JROedf SMKVAEkQMwLm\">yJW O jrq JROedf SMKVAEkQMwLm<\/a> --><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>(JAMA) Recurrence of symptoms after finishing treatment for COVID-19 with nirmatrelvir-ritonavir (Paxlovid) has become increasingly recognized.1&#8211;3\u00a0The biological underpinning of this phenomenon is unclear, and its etiology may be multifactorial, including rapid clearance of nirmatrelvir coupled with delayed immune responses or possible development of drug resistance.1&#8211;3\u00a0The contribution of treatment to symptom rebound needs to be differentiated [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[11,16],"tags":[],"class_list":["post-1134","post","type-post","status-publish","format-standard","hentry","category-covid","category-published-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/1134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=1134"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/1134\/revisions"}],"predecessor-version":[{"id":1135,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/1134\/revisions\/1135"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=1134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=1134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=1134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}