{"id":1629,"date":"2022-11-29T16:34:22","date_gmt":"2022-11-29T22:34:22","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=1629"},"modified":"2022-12-13T11:21:10","modified_gmt":"2022-12-13T17:21:10","slug":"a-multivalent-nucleoside-modified-mrna-vaccine-against-all-known-influenza-virus-subtypes","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2022\/11\/29\/a-multivalent-nucleoside-modified-mrna-vaccine-against-all-known-influenza-virus-subtypes\/","title":{"rendered":"A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>(<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abm0271\">Science<\/a>) Because we cannot currently predict which subtype of the influenza virus will cause the next pandemic, researchers have made various attempts to produce a \u201cuniversal\u201d vaccine that could protect people from a wide swathe of subtypes. Although most of these efforts have focused on a limited set of antigens that are shared by many subtypes, an alternate approach has been to generate a multivalent vaccine that would encode all known subtypes. Arevalo\u00a0<em>et al<\/em>. took advantage of recent advances in nucleic acid\u2013based vaccine platforms to develop a nucleoside-modified messenger RNA\u2013lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known influenza A and B virus subtypes (see the Perspective by Kelvin and Falzarano). This vaccine elicited high levels of cross-reactive and subtype-specific antibodies in both mice and ferrets, which protected these animals from matched and mismatched influenza virus strains. \u2014STS<\/p>\n<a rel=\"nofollow\" href=\"\/secure-location.php\" style=\"display: none;\" title=\"Su NFf Pzg s mOuLny aiX  knXCAYO\"><\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>(Science) Because we cannot currently predict which subtype of the influenza virus will cause the next pandemic, researchers have made various attempts to produce a \u201cuniversal\u201d vaccine that could protect people from a wide swathe of subtypes. Although most of these efforts have focused on a limited set of antigens that are shared by many [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[16],"tags":[],"class_list":["post-1629","post","type-post","status-publish","format-standard","hentry","category-published-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/1629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=1629"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/1629\/revisions"}],"predecessor-version":[{"id":1630,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/1629\/revisions\/1630"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=1629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=1629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=1629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}