{"id":2487,"date":"2013-05-02T15:07:00","date_gmt":"2013-05-02T20:07:00","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=2487"},"modified":"2023-02-09T15:08:15","modified_gmt":"2023-02-09T21:08:15","slug":"h5n1-hybrid-viruses-bearing-2009-h1n1-virus-genes-transmit-in-guinea-pigs-by-respiratory-droplet","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2013\/05\/02\/h5n1-hybrid-viruses-bearing-2009-h1n1-virus-genes-transmit-in-guinea-pigs-by-respiratory-droplet\/","title":{"rendered":"H5N1 Hybrid Viruses Bearing 2009\/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>(<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.1229455\">Science<\/a>) Currently, there is anxiety that the avian H5N1 influenza virus will reassort with the highly transmissible and epidemic H1N1 subtype to trigger a virulent human pandemic.\u00a0<strong>Y. Zhang\u00a0<em>et al.<\/em><\/strong>\u00a0(p.\u00a0<a href=\"https:\/\/doi.org\/10.1126\/science.1229455\">1459<\/a>, published online 2 May) used reverse genetics to make all possible reassortants between a virulent bird H5N1 with genes from a human pandemic H1N1. Virulence was tested in mice and transmissibility was tested between guinea pigs, which have both avian- and human-like airway influenza virus receptors. To assess what is happening to the receptor-ligand interactions as a result of these mutations,\u00a0<strong>W. Zhang\u00a0<em>et al.<\/em><\/strong>\u00a0(p.\u00a0<a href=\"https:\/\/doi.org\/10.1126\/science.1236787\">1463<\/a>, published online 2 May) probed the structure of both wild-type and mutant hemagglutinin of H5 in complex with analogs of the avian and human receptor types. Certain mutations in the receptor-binding site changed binding affinity.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>(Science) Currently, there is anxiety that the avian H5N1 influenza virus will reassort with the highly transmissible and epidemic H1N1 subtype to trigger a virulent human pandemic.\u00a0Y. Zhang\u00a0et al.\u00a0(p.\u00a01459, published online 2 May) used reverse genetics to make all possible reassortants between a virulent bird H5N1 with genes from a human pandemic H1N1. Virulence was [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[56],"tags":[],"class_list":["post-2487","post","type-post","status-publish","format-standard","hentry","category-avian-influenza-published-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/2487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=2487"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/2487\/revisions"}],"predecessor-version":[{"id":2488,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/2487\/revisions\/2488"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=2487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=2487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=2487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}