{"id":3495,"date":"2023-05-09T16:52:48","date_gmt":"2023-05-09T21:52:48","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=3495"},"modified":"2023-05-09T16:52:51","modified_gmt":"2023-05-09T21:52:51","slug":"long-covid-may-affect-genes-involved-in-pain-signaling","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/05\/09\/long-covid-may-affect-genes-involved-in-pain-signaling\/","title":{"rendered":"Long Covid May Affect Genes Involved in Pain Signaling"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.painnewsnetwork.org\/stories\/2023\/5\/9\/long-covid-may-change-genes-involved-in-pain-signaling\">Pain News Network<\/a>  <\/p>\n\n\n\n<p>About 16 million people in the United States have Long Covid, a poorly understood disorder that causes body aches, headaches, fatigue, insomnia, brain fog and other symptoms long after an initial infection with COVID-19. For some, the symptoms are mild, but for other they are so severe they become disabling.<\/p>\n\n\n\n<p>Why do some people quickly recover from Covid, while about one in five have lingering symptoms?<\/p>\n\n\n\n<p>A new animal study found that thousands of genes involved in nervous system function are affected by SARS-CoV-2, and may cause lasting damage to dorsal root ganglia, the spinal nerves that carry pain and other sensory messages to the brain. Scientists believe that genetic damage may be what causes Long Covid.<\/p>\n\n\n\n<p>\u201cSeveral studies have found that a high proportion of Long Covid patients suffer from abnormal perception of touch, pressure, temperature, pain or tingling throughout the body. Our work suggests that SARS-CoV-2 might induce lasting pain in a rather unique way, emphasizing the need for therapeutics that target molecular pathways specific to this virus,\u201d explains co-author Venetia Zachariou, PhD, chair of pharmacology, physiology &amp; biophysics at Boston University\u2019s Chobanian &amp; Avedisian School of Medicine. [<a href=\"https:\/\/www.science.org\/doi\/10.1126\/scisignal.ade4984\">Related Study in Science<\/a>]<\/p>\n\n\n\n<p>Zachariou and her colleagues infected hamsters with SARS-CoV-2 and studied how it affected the animals\u2019 sensitivity to touch, both during the initial infection and after the infection had cleared. Then they compared the effects of SARS-CoV-2 to those triggered by an influenza A virus infection, and were surprised by what they found.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.painnewsnetwork.org\/stories\/2023\/5\/9\/long-covid-may-change-genes-involved-in-pain-signaling\">Continue reading<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Pain News Network About 16 million people in the United States have Long Covid, a poorly understood disorder that causes body aches, headaches, fatigue, insomnia, brain fog and other symptoms long after an initial infection with COVID-19. For some, the symptoms are mild, but for other they are so severe they become disabling. Why do [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"New study @science found that thousands of genes in nervous system function affected by SARS-CoV-2,  may cause lasting damage to spinal nerves that carry pain","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[13,34],"tags":[],"class_list":["post-3495","post","type-post","status-publish","format-standard","hentry","category-clinical-considerations","category-long-covid"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/3495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=3495"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/3495\/revisions"}],"predecessor-version":[{"id":3496,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/3495\/revisions\/3496"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=3495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=3495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=3495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}