{"id":3497,"date":"2023-05-09T16:53:59","date_gmt":"2023-05-09T21:53:59","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=3497"},"modified":"2023-05-09T16:54:01","modified_gmt":"2023-05-09T21:54:01","slug":"sars-cov-2-airway-infection-results-in-the-development-of-somatosensory-abnormalities-in-a-hamster-model","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/05\/09\/sars-cov-2-airway-infection-results-in-the-development-of-somatosensory-abnormalities-in-a-hamster-model\/","title":{"rendered":"SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/scisignal.ade4984\">Science<\/a> Some people infected with SARS-CoV-2, the virus that causes COVID-19, experience a range of symptoms after the resolution of infection, such as neurological issues that include generalized pain, neuropathy, and myalgia. Serafini\u00a0<em>et al<\/em>. found that non-infectious viral RNA was detectable in the dorsal root ganglia of hamsters after intranasal infection with SARS-CoV-2. This phenomenon was associated with a durable gene expression signature in sensory neurons that partly resembled those of mouse models of inflammatory and injury-induced neuropathic pain but was distinct from those in mice infected with influenza virus. The findings further identify the cytokine-associated factor ILF3 and other potential therapeutic targets to treat pain associated with long COVID and other neuropathies<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Science Some people infected with SARS-CoV-2, the virus that causes COVID-19, experience a range of symptoms after the resolution of infection, such as neurological issues that include generalized pain, neuropathy, and myalgia. Serafini\u00a0et al. found that non-infectious viral RNA was detectable in the dorsal root ganglia of hamsters after intranasal infection with SARS-CoV-2. This phenomenon [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":false,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[34,16],"tags":[],"class_list":["post-3497","post","type-post","status-publish","format-standard","hentry","category-long-covid","category-published-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/3497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=3497"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/3497\/revisions"}],"predecessor-version":[{"id":3498,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/3497\/revisions\/3498"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=3497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=3497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=3497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}