{"id":4322,"date":"2023-08-15T15:35:02","date_gmt":"2023-08-15T20:35:02","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=4322"},"modified":"2023-08-15T15:37:16","modified_gmt":"2023-08-15T20:37:16","slug":"long-covid-mitochondria-the-big-miss-and-hope","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/08\/15\/long-covid-mitochondria-the-big-miss-and-hope\/","title":{"rendered":"Long COVID: Mitochondria, the Big Miss, and Hope"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.medscape.com\/viewarticle\/995433?form=fpf\">Medscape<\/a> <\/p>\n\n\n\n<p>This week there was news on Long COVID in two very different directions: emergence of strong data to support mitochondrial dysfunction as the basis for the condition in some people, and learning how the $1.15 billion allocation to the NIH RECOVER initiative has largely been wasted. In this edition of Ground Truths, I&#8217;ll review this news and offer a plan to get clinical trials testing treatments into high gear.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Sick Mitochondria as a Root Cause<\/strong><\/h3>\n\n\n\n<p>When we published our review of Long COVID earlier this year, we highlighted the key established underpinnings as shown in the figure below. As you&#8217;ll note, mitochondria was not one of them. There was a body of data emerging to support the role of mitochondria, as we asserted: &#8220;Long COVID research has found mitochondrial dysfunction including loss of mitochondrial membrane potential and possible dysfunctional mitochondrial metabolism, altered fatty acid metabolism\u2026&#8221; and that this had also been seen in&nbsp;<a href=\"https:\/\/emedicine.medscape.com\/article\/235980-overview\">myalgic encephalomyelitis<\/a>&nbsp;(ME\/CFS).<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Medscape This week there was news on Long COVID in two very different directions: emergence of strong data to support mitochondrial dysfunction as the basis for the condition in some people, and learning how the $1.15 billion allocation to the NIH RECOVER initiative has largely been wasted. In this edition of Ground Truths, I&#8217;ll review [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[34],"tags":[],"class_list":["post-4322","post","type-post","status-publish","format-standard","hentry","category-long-covid"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=4322"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4322\/revisions"}],"predecessor-version":[{"id":4323,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4322\/revisions\/4323"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=4322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=4322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=4322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}